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Training to Reduce Care-Resistant Behaviors in Alzheimer's and TBI (NeuroNS-Care)

Recruiting

This study will test the effectiveness of an Internet-based distance-learning program in reducing care-resistant behaviors, including agitation, aggression, and irritability, in people with Alzheimer's disease or traumatic brain injury (TBI).

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All Yes
February 1, 2017
December 31, 2019
150

  • Possible or probable Alzheimer's disease (of all severity stages) or moderate to severe TBI at least 6 months prior to study enrollment
  • Family caregiver (unpaid) who provides support or supervision for at least one instrumental activity of daily living for the affected person, with direct contact averaging 5 of every 7 days, and 21 hours weekly
  • Caregiver report of agitation/aggression, disinhibition, or irritability on the Neuropsychiatric Inventory that is triggered by resistance to care-related activities, such as bathing, taking medications, or attending healthcare appointments
  • Generally healthy and able to walk (assistance devices such as a walker or cane are allowed)
  • Vision and hearing sufficient to complete testing procedures (hearing aid allowed)
  • Cognitive function and spoken/written English sufficient to complete neuropsychological testing
  • May be on stable doses of psychoactive agents for at least 30 days
  • Access to high-speed/broadband Internet service through home computer capable of operating conference software

  • Evidence of other psychiatric/neurological disorders that could be the primary source of cognitive impairment, such as stroke, Parkinson's disease, schizophrenia, bipolar or unipolar depression, and seizure disorder
  • Psychotic features, such as delusions or hallucinations, that are not adequately treated or not on stable medical therapy for at least 30 days
  • Alcoholism or drug misuse within past 2 years
  • Any condition that would make the participant or caregiver unsuitable for the study

The Neurobehavioral Non-Pharmacologic Supportive Strategies for Family Caregivers of Persons with Dementia or TBI (NeuroNS-Care) is a training and coaching program that researchers are investigating to improve caregiver burden, quality of life, and related outcomes of people with these conditions and their family members. Caregivers of the person with Alzheimer's or TBI will complete online coaching sessions weekly for 6 weeks. The web-based courses contain instructional materials that deal with preventing and reducing care-resistant behavior during intimate-care activities, such as dressing, bathing, and toileting, and treatment activities, such as supervising medications.

Name City State Zip Status Primary Contact
University of Alabama at Birmingham
Birmingham Alabama 35233 Recruiting Vicki Winstead, Phd
205-934-9260
vickiwin@uab.edu

University of Alabama at Birmingham

Name Role Affiliation
David Geldmacher, MD Principal Investigator University of Alabama at Birmingham

Name Phone Email
Vicki Winstead, PhD 205-934-9260 vickiwin@uab.edu
Giovanna Pilonieta, DDS, MPH 205-934-1821 gpilonieta@uabmc.edu

NCT03734289

Improving Family Quality of Life Through Training to Reduce Care-Resistant Behaviors by People With Alzheimer Dementia and Traumatic Brain Injury (NeuroNS) Study