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Therapeutic Diets in Alzheimer's Disease

Recruiting

In this study researchers will investigate how the ketogenic and Therapeutic Lifestyle Changes diets affect cognition in adults with Alzheimer's disease.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 90 Years All No
October 29, 2019
November 2023
80

  • Diagnosis of Alzheimer's disease
  • Clinical Dementia Rating global score of 0.5 or 1 (very mild or mild dementia)
  • Agreed cooperation from an appropriate study partner
  • Speaks English as primary language
  • No medication changes in past 30 days

  • Resides in a nursing home or dementia special care unit, or cannot control diet
  • A potentially confounding serious medical risk (e.g., diabetes requiring insulin; cancer requiring chemotherapy or radiation within the past 5 years; or a recent heart attack, angioplasty, or other cardiac event)
  • Participating in another clinical trial or using an investigational drug or therapy within 30 days of screening
  • History of renal stones

Participants will be randomly assigned to one of two diets for 3 months.

  • The ketogenic diet is a high-fat, low-carbohydrate diet (approximately 70 percent fat, less than 10 percent carbohydrate, and 20 percent protein). The diet will encourage 4 or more servings of non-starchy vegetables and 1/2 cup of berries daily. Participants will also take daily supplements.
  • The Therapeutic Lifestyle Changes diet is low in fat and cholesterol; high in fruits, vegetables, and whole grains; and moderate in protein (20 to 35 percent fat, 50 to 60 percent carbohydrate, and approximately 15 percent protein). Participants will be encouraged to eat two or more servings of fruit and five or more servings of vegetables per day.

Researchers will measure changes in cognitive performance, including memory and reaction times, using several assessments and tests.

Name City State Zip Status Primary Contact
Clinical and Translational Science Unit
Fairway Kansas 66205 Recruiting

University of Kansas Medical Center

  • National Institute on Aging (NIA)

Name Phone Email
Jessica Keller, MS 913-588-5355 kkali17@kumc.edu
Matthew Taylor, PHD 913-588-5363 mtaylor3@kumc.edu

NCT03860792

Therapeutic Diets in Alzheimer's Disease