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Tau PET Imaging in the Dominantly Inherited Alzheimer Network


This study will evaluate a new radioactive compound, [18F]T807, used in positron emission tomography (PET) scans to identify tau tangles, a protein in the brain that is associated with Alzheimer's disease.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A Both No
May 1, 2019
September 2020

  • Meet all eligibility criteria for enrollment into the Dominantly Inherited Alzheimer Network or the Dominantly Inherited Alzheimer Network Extended Registry
  • Cognitively normal or with mild dementia, as assessed clinically
  • Able and willing to undergo radioactive tracer injection and brain scan
  • Pregnancy test for premenopausal women, given within 24 hours of [F18]T807 administration

  • Any condition that could increase risk to participant, limit participant's ability to tolerate the experimental procedures, or interfere with the collection/analysis of data
  • Likely unable to undergo the imaging procedures
  • High risk for torsades de pointes or taking medications known to prolong QT interval
  • Hypersensitivity to [F18]T807 or any of its components
  • Contraindications to PET, PET-CT or MRI scans (for example, electronic medical devices, inability to lie still for long periods, severe claustrophobia)
  • Currently pregnant or breastfeeding, women who do not agree to use reliable contraception, or to refrain from sexual activity for 24 hours following administration

This Phase II study involves PET scans using an experimental brain imaging agent, [F18]T807, to measure tau deposition in the brain. Participants will undergo one scan, for which the imaging agent will be injected. Investigators hypothesize that this brain imaging method will demonstrate the presence of tau fibrils in the brain during the presymptomatic stages of cognitive decline, prior to cerebral atrophy, hypometabolism, and dementia. They also predict that a person's conversion from cognitively normal status to early-stage cognitive impairment will be closely correlated with uptake of [F18]T807. The study will help determine if this type of PET imaging can predict the onset of dementia more accurately than existing biomarkers.

Name City State Zip Status Primary Contact
Washington University School of Medicine
Saint Louis Missouri 63110 Recruiting Kelley Jackson

Washington University School of Medicine

Name Role Affiliation
Tammie Benzinger, MD, PhD Principal Investigator Washington University School of Medicine

Name Phone Email
Lisa Cash, BA 314-226-5943


F 18 T807 Tau PET Imaging in Dominantly Inherited Alzheimer's Network (IND #123119 Protocol D)