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Tau PET Imaging and Cognition

Recruiting

This study will use the new radioactive tracer 18F-MK-6240 in positron emission tomography (PET) scanning to detect tau pathology in older adults who are cognitively healthy and mildly cognitively impaired.

Minimum Age Maximum Age Gender Healthy Volunteers
55 Years 90 Years All Yes
June 1, 2018
December 2023
65

  • Participation in amyloid PET scanning study
  • Reside near Columbia University Medical Center
  • Willing and able to participate

  • Inability to undergo PET, such as metallic implants, pacemaker, claustrophobia, or difficulty lying flat for one hour
  • Pregnant or lactating
  • Current, past, or anticipated exposure to radiation
  • Significant active physical illness

Tau is a protein that accumulates abnormally in the brains of people with Alzheimer's disease and other dementias. In this study researchers will examine the interactions between tau levels and performance on cognitive tasks, functional magnetic resonance imaging neural activation patterns, and other cognitive and behavioral measures. The study also aims to examine how the presence of tau may contribute to the risk of subsequent cognitive decline, neurodegeneration, and dementia.

Name City State Zip Status Primary Contact
Columbia University Medical Center
New York New York 10032 Recruiting Ann Ann Ohkawa
212-305-6314
ao2454@cumc.columbia.edu

Yaakov Stern

  • National Institute on Aging (NIA)

Name Role Affiliation
Yaakov Stern, PhD Principal Investigator Columbia University

Name Phone Email
Ann Ohkawa 212-305-6314 ao2454@cumc.columbia.edu
Ashley Mensing, BS 212-305-6314 anm2186@cumc.columbia.edu

NCT03372317

Tau Positron Emission Tomography (PET) in Imaging and Cognition