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Study to Evaluate Amyloid in Blood and Imaging Related to Dementia (SEABIRD)

Recruiting

This study will evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease, in older adults. Researchers are recruiting people with and without memory problems.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years N/A All Yes
April 2019
August 2023
1120

  • None

  • Unable to perform one or more activities of daily living, such as eating, bathing, dressing, walking, and toileting) or dependent on others due to cognitive impairment
  • Weigh less than 100 pounds
  • Active infectious disease, such as HIV, hepatitis B, or hepatitis C
  • Bleeding disorder
  • Pacemaker
  • Taking an experimental drug for Alzheimer's disease
  • Blood donation in the last 2 months
  • Blood transfusion in the last 3 months
  • On hospice

Amyloid-beta is a protein that builds up abnormally in the brains of people with Alzheimer's disease. Researchers are investigating the ability of a blood test to detect this protein in order to screen people for the early signs of the disease. Participants will undergo blood collection and cognitive testing, and may be asked to undergo positron emission tomography and magnetic resonance imaging.

Name City State Zip Status Primary Contact
Washington University School of Medicine
Saint Louis Missouri 63110 Recruiting Melissa Sullivan
314-747-4857
m.sullivan@wustl.edu

Washington University School of Medicine

Name Role Affiliation
Randall Bateman, MD Principal Investigator Washington University School of Medicine

Name Phone Email
Melissa Sullivan 314-747-4857 m.sullivan@wustl.edu
Tinishia Greene 314-273-7935 greene.t.d@wustl.edu

NCT03899844

Blood Amyloid-Beta Relationship With Amyloid Plaques and CSF Amyloid-Beta