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Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI)


Dementia is considered to be present when a person can no longer handle complex activities of daily living, such as managing finances. This study will investigate the relationship between changes in the ability to handle finances and brain perfusion (blood flow in the brain), as measured by arterial spin-labeling MRI. Subjects will also undergo neuropsychological tests focusing on several types of memory and thought processes, with special emphasis on semantic memory. The study will examine whether changes in financial capacity are better predicted by neuropsychological tests or the brain scan.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 89 Years Both Accepts Healthy Volunteers
April 2009
December 2014

++Normal cognition or memory impairment (MCI or mild Alzheimer's disease)++English speaking++Right handed++Adequate vision and hearing to take part in tests++Able and willing to undergo MRI scan++Medically and psychiatrically stable

++Brain disease (such as tumor, Parkinson's disease, major stroke)++Pregnancy++Inability to tolerate MRI (due to metal in body or claustrophobia)

None provided.

Name City State Zip Status Primary Contact
Birmingham VA Medical Center, Birmingham, AL
Birmingham Alabama 35233

Department of Veterans Affairs

  • University of Alabama at Birmingham

Name Role Affiliation
David G. Clark, MD Principal Investigator VA Medical Center, Birmingham

Name Phone Email
David G. Clark, MD 205-996-6050
Kathryn L. Burgio, PhD 205-933-8101


Semantic Memory, Financial Capacity and Brain Perfusion in MCI