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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 28

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

AL001 for Frontotemporal Dementia in Healthy Volunteers and People with FTD

Purpose: To assess the safety, tolerability, and behavior of the drug AL001 in healthy adult volunteers and people with frontotemporal dementia and the granulin mutation.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

Amyotrophic Lateral Sclerosis (ALS) Families Project

Purpose: To learn how and why motor neuron degeneration begins and progresses in families affected by familial amytrophic lateral sclerosis (ALS).

BIIB092 in Primary Tauopathies

Purpose: To test the safety, tolerability, and effects of the investigational drug BIIB092 in people with one of four different tauopathy syndromes.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

D-CARE: The Dementia Care Study

Purpose: To compare the effectiveness of two evidence-based models of dementia care.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

LY3154207 for Parkinson's Disease Dementia (PRESENCE)

Purpose: To evaluate the safety and efficacy of the investigational drug LY3154207 in people with mild-to-moderate Parkinson's disease dementia.

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

Neural Basis of Frontotemporal Degeneration and Related Disorders

Purpose: To study adults with frontotemporal degeneration, multiple systems atrophy, and progressive supranuclear palsy to better understand the causes of these disorders.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

North American Prodromal Synucleinopathy (NAPS) Consortium

Purpose: To enroll adults with idiopathic rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.

PET Imaging of Neuroinflammation in Neurodegenerative Diseases

Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.

Palliative Care for Parkinson's and Related Disorders

Purpose: To compare usual care to palliative care for adults with Parkinson's disease and related disorders.

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

Speech Language Therapy for Primary Progressive Aphasia

Purpose: To evaluate two evidence-based speech language therapy treatments for adults with mild primary progressive aphasia.

Targeting Verbal Short-Term Memory in Conjunction with tDCS in Neurodegenerative Disorders

Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.

Transcranial Direct Current Stimulation and Language Therapy for Primary Progressive Aphasia

Purpose: To investigate the effects of transcranial direct current stimulation (tDCS) and language therapy on adults with PPA.

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

Voices of Individuals: Challenges and Experiences of bvFTD

Purpose: To understand how behavioral variant frontotemporal dementia (bvFTD) affects people's day-to-day lives, how people think about themselves, and what challenges they face.