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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 50

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

AL001 for Frontotemporal Dementia

Purpose: To evaluate the safety and tolerability of AL001 in participants with frontotemporal dementia caused by a granulin mutation or C9orf72 mutation.

A-LIST: Patients and Families Transforming Alzheimer's Disease

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Research Consortium

Purpose: To collect and study data from people with frontotemporal lobar degeneration and their family members to understand changes in brain function and biomarkers as the disease progresses.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

Amyotrophic Lateral Sclerosis (ALS) Families Project

Purpose: To learn how and why motor neuron degeneration begins and progresses in families affected by familial amytrophic lateral sclerosis (ALS).

Biomarkers in Lewy Body Dementia

Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

CARE Registry for Asian Americans and Pacific Islanders

Purpose: To enroll Asian, Asian Americans, and Pacific Islanders who are interested in participating in research on Alzheimer's disease and related dementias, aging, and caregiving.

Caring Response: A Mobile Training App for Family Caregivers

Purpose: To determine if the mobile training app, Caring Response, can improve coping skills and quality of life for family caregivers of someone with Alzheimers disease.

D-CARE: The Dementia Care Study

Purpose: To compare the effectiveness of two evidence-based models of dementia care.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

Electrical Stimulation and Verbal Memory in Alzheimer's Disease

Purpose: To test transcranial direct current stimulation (tDCS) to slow nerve cell damage in the brain and improve verbal memory in people with Alzheimer's disease.

FTD Disorders Registry

Purpose: To gather information from people affected by frontotemporal degeneration (FTD), including people diagnosed with FTD, caregivers, friends, and family, and provide information about FTD study opportunities.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Hearing Aids and Individuals with Cognitive Disorders

Purpose: To evaluate procedures that will help determine the impact of hearing aid interventions on older individuals with Alzheimer's disease and related dementias.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment

Purpose: To develop and evaluate an in-home supportive technology to help alleviate anxiety, burden, and loneliness in family caregivers of people with Alzheimer's disease, related dementias, or mild cognitive impairment.

In-Home Technology for Dementia Caregivers

Purpose: To develop and evaluate in-home assistive technology to alleviate anxiety, burden, and loneliness in caregivers of people with Alzheimer's disease and frontotemporal dementia.

Individualized Online Care Planning Tool for Family Members of Persons With Dementia

Purpose: To test an online care planning tool designed to provide individualized information to better serve the diverse needs of caregivers and care recipients living with Alzheimer's disease or a related dementia.

Insomnia Therapy for People Living With Dementia and Their Caregivers

Purpose: To test cognitive behavioral therapy for insomnia to improve the sleep of community-dwelling persons living with dementia and their caregivers.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Mobile App to Monitor Dementia-Related Agitation

Purpose: To test a mobile application designed to monitor and support individuals with dementia-related agitation.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

Neurofilament Biomarker for Frontotemporal Lobar Degeneration

Purpose: To determine if neurofilament light chain can be used as an early biomarker for frontotemporal lobar degeneration.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

North American Prodromal Synucleinopathy (NAPS) Consortium

Purpose: To enroll adults with idiopathic rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.

Online Self-Management Workshop for Rural Dementia Caregivers

Purpose: To evaluate an interactive, online workshop designed to support isolated dementia caregivers in rural areas and reduce caregiver stress and depression.

Online Support and Skills Training for Dementia Caregivers

Purpose: To test the effectiveness of GamePlan4Care (GP4C), an evidence-based, online system designed to provide accessible, tailored caregiver support and skills training.

PET Imaging of Neuroinflammation in Neurodegenerative Diseases

Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.

Pimavanserin for Psychological Symptoms of Dementia

Purpose: To determine whether treatment with the drug pimavanserin decreases the psychological symptoms of dementia in older adults.

Posiphen for Early-Stage Alzheimer's and Parkinson's Diseases

Purpose: To determine the safety and tolerability of Posiphen in people with early Alzheimer's or early Parkinson's disease.

ResearchMatch

Purpose: To connect people interested in health research with studies that match their interests.

Retinal Imaging for the Diagnosis of Cognitive Disorders and Dementia

Purpose: To test the effectiveness of a retinal imaging system to measure changes in the eye to diagnose cognitive disorders and dementia.

Skills Training for Caregivers of People With Primary Progressive Aphasia

Purpose: To adapt and test the Tele-Savvy online caregiver training program to address the unique challenges of caregiving for a person with primary progressive aphasia.

Skills Training for LGBT Dementia Caregivers

Purpose: To test the design of a caregiver training program developed to address the unique challenges facing lesbian, gay, bisexual, and transgender (LGBT) caregivers of a person living with dementia.

SmartPrompt Electronic Reminder Aid to Improve Everyday Function in People With Dementia

Purpose: To evaluate the use of SmartPrompt, a smartphone-based electronic reminder aid that is designed to help older adults with dementia perform daily tasks.

Speech Language Therapy for Primary Progressive Aphasia

Purpose: To evaluate two evidence-based speech language therapy treatments for adults with mild primary progressive aphasia.

Stress Reduction for Partners of People With Early-Stage Dementia

Purpose: To test whether the Wish Outcome Obstacle Plan lowers the stress of partners and spouses of people with early-stage dementia.

Studying the Role of Inflammation in Parkinson's and Alzheimer's diseases

Purpose: To better understand the role of the immune response, including inflammation, in Parkinson's disease (PD) and Alzheimer's disease (AD).

Targeting Verbal Short-Term Memory in Conjunction with tDCS in Neurodegenerative Disorders

Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.

The STELLA Collaborative: Using Technology to Advance Alzheimer's Disease and Related Dementias Family Education and Support

Purpose: To study the use of a videoconference-based system known as Support via Technology: Living and Learning with Advancing Alzheimer's Disease and Related Dementias to provide education and support to family caregivers, as well as the person with dementia.

Transcranial Direct Current Stimulation and Language Therapy for Primary Progressive Aphasia

Purpose: To investigate the effects of transcranial direct current stimulation (tDCS) and language therapy on adults with PPA.

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.

Translating a Dementia Caregiver Intervention Into a Mobile Application

Purpose: To develop and test a mobile health application, the CARE-well App, that will provide resources to support informal dementia caregivers.

TrialMatch

Purpose: To help people interested in joining a clinical trial find studies related to Alzheimer's disease and related dementias.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

Voices of Individuals: Challenges and Experiences of bvFTD

Purpose: To understand how behavioral variant frontotemporal dementia (bvFTD) affects people's day-to-day lives, how people think about themselves, and what challenges they face.