Skip to main content

Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 62

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

This Phase III Clinical Trial Will Evaluate Whether AGB101 Slows Cognitive And Functional Impairment In People With Prodromal Alzheimer's Disease (mild Cognitive Impairment Due To Alzheimer's)

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

The A-LIST Is An Online Community Of People With Or At Risk For Alzheimers Disease, Other Dementias, And Mild Cognitive Impairment (MCI), Along With Current And Former Care Partners, Designed To Increase Patient And Caregiver Engagement In Research.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

This Phase II Study Will Assess The Safety, Tolerability, And Effects Of The Investigational Drug AMX0035 For People With Late Mild Cognitive Impairment Or Early Dementia Due To Alzheimer's Disease.

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Combining Aerobic Exercise And Cognitive Training, This Study Will Compare The Effects Of Cycling And Cognitive Training Alone And Together in Older Adults With Mild Cognitive Impairment (MCI).

Alzheimer Prevention Trials (APT) Webstudy

Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

The Alzheimer Prevention Trials (APT) Webstudy Is An Online Registry Designed To Accelerate Enrollment For Alzheimer's Disease Clinical Trials By Identifying And Tracking Individuals Who May Be At Higher Risk For Developing Alzheimer's dementia.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

The Purpose Of This Observational Study Is To Determine The Relationships Among Clinical, Cognitive, Imaging, Genetic, And Biomarker Characteristics Of The Entire Spectrum Of Alzheimer's Disease As It Progresses From A Preclinical Stage To Very Mild Symptoms To Mild Cognitive Impairment (MCI) To Dementia. Participants Sought Include Those With Normal Cognition, MCI, Or Mild Alzheimer's Dementia (currently Recruiting Non-Caucasian Participants Only For The Normal Cognition Group).

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

The Alzheimer's Prevention Registry Is A National Registry Of Individuals Age 18 And Older Who Are Interested In Learning About And Possibly Participating In Alzheimer's Prevention Clinical Studies And Trials. The Registry Will Collect Contact And Demographic Information, Provide Information About The Latest News And Advances In Alzheimer's Prevention Research, And Inform Enrollees About Research Studies In Their Community.

BAN2401 for People with Early Alzheimer's Disease

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease

This Phase III Trial Will Test The Effectiveness Of The Experimental Drug BAN2401 As A Possible Treatment For Alzheimer's Disease. 

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

People With Mild Cognitive Impairment (MCI) Are At Risk Of Developing Dementia. Those With Deficits In Short-term Recall (amnestic MCI) Are At Significant Risk Of Developing Alzheimer's Disease. In This Study, People With MCI And Prediabetes Will Consume A Nutraceutical Drink, Called A Bioactive Dietary Polyphenol Preparation (BDPP), To See If It Can Improve Cognition And Delay Or Prevent Dementia.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

This Study Will Evaluate The Safety And Tolerability Of BIIB076 In Cognitively Normal Older Adults And Older Adults With Alzheimer's Disease.

Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.

Disruption Of The Blood-brain Barrier, Which Is Important For Protecting The Brain, Could Be An Early Process That Precedes Alzheimer's Disease. This Study Will Test A Method For Measuring Disruptions To The Blood-brain Barrier Using Advanced Magnetic Resonance Imaging (MRI) Methods In Cognitively Normal Younger And Older Adults And Adults With Mild Cognitive Impairment (MCI), A Condition That Puts People At Higher Risk For Alzheimer's.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Traumatic Brain Injury (TBI) And Post Traumatic Stress Disorder (PTSD) Are Common Combat-related Problems And May Be Associated With A Greater Risk Of Alzheimer's Disease. This Study Will Examine The Possible Connections Between TBI And PTSD, And The Signs And Symptoms Of Alzheimer's In Vietnam War Veterans As They Age.

Brain Energy Metabolism and Sleep in Adults

Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.

The First Phase Of This Study Will Investigate the Relationship Of sleep Abnormalities, Genes, And Brain Energy with Cognitive Performance Among People Who Are Cognitively normal, Have Mild Cognitive Impairment, Or Have Alzheimer's Disease. The Second Phase Will Test The Effects Of An Oral Airway Management System On Sleep And Cognition.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

The Purpose Of The Online Brain Health Registry Is To Recruit And Observe People Who Are Interested In Promoting Healthy Brain Function Through The Prevention Of Brain Diseases, Disorders, And Injuries In Adults. Participation Involves Answering Questions About Your Health, Lifestyle, And Medical History And Taking Online Brain Tests. Researchers Hope To Build A Large Pool Of Potential Participants For Clinical Trials, Reducing The Time And Cost Of Research.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

The Purpose Of This 1-year Study Is To Determine Whether Treatment Of Obstructive Sleep Apnea With A Continuous Positive Airway Pressure (CPAP) Machine Can Delay The Progression Of Cognitive Impairment In Older Adults With Mild Cognitive Impairment (MCI).

Calorie Restriction and Brain Function in Mild Cognitive Impairment

Purpose: To test the effects of intermittent calorie restriction in older adults with mild cognitive impairment who are overweight or obese.

Problems With Blood Sugar Metabolism, Known As Metabolic Dysfunction, Increase Risk For Alzheimer's Disease And Affect memory And Related Brain Function. This Study Will Test Intermittent Calorie Restriction As A Way To Reduce Metabolic Dysfunction In Older Adults With Mild Cognitive Impairment (MCI), A Precursor To Alzheimer's Disease, Who Are Overweight Or Obese.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

This Phase II Study Will Investigate The Effect Of Candesartan, A Medication Used To Treat High Blood Pressure, On Cognitive Function In People With Mild Cognitive Impairment (MCI), A Condition Of Higher-than-normal Memory And Thinking Difficulties For One's Age.

Cathodal Transcranial Direct Current Stimulation in MCI

Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.

This Study Is Evaluating the Application Of Cathodal Transcranial Direct Current Stimulation (tDCS) using An Investigational Device To Treat Mild Cognitive Impairment In Older Adults.

Cleveland Clinic Healthy Brains Registry

Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.

The Purpose Of The Healthy Brains Registry Is To Build A Community Of People Interested In Brain Health Clinical Research And To Advance Knowledge Of Brain Health Using Data Collected In The Registry.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

The COCOA Study Will Test The Effects Of 2 Years Of Coaching In Adults With Mild Cognitive Impairment (MCI) And Alzheimer's Disease. Researchers Believe That Providing Coaching, In Addition To Routine Care, May Improve Memory, Cognitive Function, And Quality Of Life.

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Behavioral Therapy (CBT) Is A Psychological Approach That Addresses The Interaction Between People's Thoughts, Feelings, And Behavior. This Study Will Test The Effects Of CBT compared With Usual Care In Reducing Stress Levels And Improving Cognitive Performance In African-American Adults With Mild Cognitive Impairment (MCI).

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

This Study Will Evaluate The Effectiveness Of A Cognitive Rehabilitation Group Treatment For Veterans With Mild Cognitive Impairment (MCI).

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

This Study Will Test The Efficacy Of Repetitive Transcranial Magnetic Stimulation (rTMS) As A Treatment For Older Adults With Mild Cognitive Impairment (MCI).

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

This Study Will Determine The Impact Of Two Interventions In People With Early Memory Problems. First, It Will Test the Clinical Benefits Of Curcumin, A Compound Isolated From turmeric Root, A component Of Indian Curry Spices That Has Been Found To Inhibit Several Potential Pathways In Alzheimer's Disease. Second, It Will determine The Effect Of adding A Yoga-based physical Exercise Program.

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

This Study Will Test Two Dietary Interventions In Overweight, Middle-aged Adults With Subjective Memory Complaints: A Powdered Berry Supplement And A Carbohydrate-restricted Diet Designed To Induce Ketone Metabolism.

E2609 for MCI and Early Alzheimer's (Mission AD1)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, for The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

E2609 for MCI and Early Alzheimer's (Mission AD2)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, For The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

This Study Will Test An Education And Skills-based Training Program For People With Early-stage Memory Loss Or Dementia And Their Care Partners. The Training Is Designed To Reduce Stress And Distress, And Increase Well-being And Quality Of Life.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

The EASES Study Is A 2-year Observational Study Designed To Measure Brain Function During The Onset And Progression Of Mild Cognitive Impairment (MCI) In Older Adults using Quantitative Electroencephalography (qEEG).

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

This Study Evaluates The Effects Of Physical Exercise On Cognition, Functional Status, Brain Atrophy, Blood Flow, And Cerebrospinal Fluid Biomarkers Of Alzheimer's Disease In Adults With A Mild Memory Impairment. Half Of Participants Will Participate In A Stretching-balance-range Of Motion Exercise Program, While The Other Half Will Participate In A Moderate- To High-intensity Aerobic Training Program.

Exercise to Improve Cognitive Function in Veterans with MCI

Purpose: To assess the feasibility of a home-based exercise intervention to improve memory in veterans with mild cognitive impairment.

This Study Will Assess The Feasibility Of A Home-based Exercise Intervention To Improve Memory In Veterans With Mild Cognitive Impairment (MCI), A Precursor To Alzheimer's Disease.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

This Exploratory Trial Will Investigate The Effects Of A Glutathione Dietary Supplement On Cognitive Function In Adults With Mild Cognitive Impairment (MCI).

High-Dose Vitamin D Supplements in Older Adults

Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.

This Phase II Study Will Test High-dose Oral Vitamin D Compared To A Standard Dose For Treating Vitamin D Insufficiency in A Diverse Group Of Older Adults. The Effects Of The Different Doses On Cognitive Function Will Also Be Assessed To Gather Data For A Potential Future Trial In Older Adults At Risk For Dementia.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

This Study Is Recruiting Adults With Or Without Neurological Or Psychiatric Conditions To Test An IPad Application Being Developed To Help Detect Neurocognitive Disorders, Such As Alzheimer's Disease And Related Dementias. 

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

This Study Will Test The Ability Of The Radioactive Tracer 11C-ER176 To Stick To Parts Of The Brain Where There Is Inflammation. Past Studies Have Shown That Inflammation Is Present In The Brains Of People With Alzheimer's Disease.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

This Study Will Test Dance And Social Engagement As A Method To Decrease Behavioral Symptoms And Improve Quality Of Life In Older Adults With Mild Cognitive Impairment (MCI) Or Early Alzheimer's Disease.

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.

This study Will Examine The Potential Effects Of 6 Months Of Computerized Cognitive Training On Large-scale Brain Networks In Older Adults With Mild Cognitive Impairment (MCI). Results Will Be Compared To Those In A Control Group Who Receive online Training In Crossword Puzzles.

Insulin Aspart to Fight Forgetfulness

Purpose: To test the effects of fast-acting intranasal insulin on cognition and daily function in people with Alzheimer's disease or mild cognitive impairment.

This Phase I Clinical Trial Will Test The Effects Of Fast-acting Intranasal Insulin On Cognition And Daily Function In People With Alzheimer's Disease Or Mild Cognitive Impairment. Researchers Will Also Examine Markers Of Alzheimer's In Blood And Cerebrospinal Fluid And Amyloid Deposition In The Brain.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Is A 2-year Observational Study Designed To Look At Disease Progression In Adults With Early-onset Alzheimer's Disease. Researchers Are Also Recruiting Cognitively Normal Volunteers For A 1-year Comparison.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

Nicotine Has Been Shown To Improve Attention, Learning, And Memory. Researchers In This Phase II Trial Will Test Whether Nicotine Delivered Via A Transdermal (skin) Patch May Improve Memory Performance In Older Adults Who Are Experiencing Mild Cognitive Impairment (MCI).

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

This Observational Study Will Examine Changes In brain-region Size, Shape, And Activity That Occur In Women With Breast Cancer And How Those Changes Relate To The Development Of Mild Cognitive Impairment. Three Groups Will Be Compared: Women With Breast Cancer Who Will Undergo Hormonal Therapy With Or Without Chemotherapy, Women With Breast Cancer Who Will Undergo No Therapy Or Radiation Therapy, And Healthy Female Volunteers.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

The Modified Story Memory Technique (mSMT) Cognitive Retraining Program Has Been Shown To Improve new Learning And Memory Function in Individuals With Multiple Sclerosis And Traumatic Brain Injury. This Study Will Measure The Effects Of MSMT In Cognitively Healthy Older Adults And Adults With Mild Cognitive Impairment. Researchers Will Determine whether Engaging In MSMT Can Enhance Memory And Learning Ability.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

This Phase II Trial Will Explore The Effects Of Music Training On Central Auditory Processing, Cognition, And Everyday Function Among Older Adults With And Without Mild Cognitive Impairment.

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

This Phase 1 Trial Will Test An Experimental Drug, NDX-1017, in Healthy Adults And People With Mild Alzheimer's Disease To Evaluate Safety, Dosing, And Action Of The Drug.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nicotinamide, Or Niacinamide, Is A Form Of Vitamin B3 That Researchers Are Exploring For Its Possible Use In Reducing tau, A Protein That Accumulates In Tangles In The Brain's Of People With Alzheimer's Disease. This Study Will Test The Effects Of A High Dose Of Nicotinamide In Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Nicotinamide Riboside for Mild Cognitive Impairment

Purpose: To test the effects of the supplement nicotinamide riboside on memory and brain blood flow in older adults with mild cognitive impairment.

This Phase I/II Study Will Test The Supplement Nicotinamide Riboside, Also Known As Niogen, As A Potential Treatment For Age-related Memory Loss.

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

This Observational Study Seeks To Better Understand The Experience And Needs Of Older Adults With Mild Cognitive Impairment (MCI) Or Alzheimer's Disease who Live Alone.

Preventing Loss of Independence Through Exercise in Mild Cognitive Impairment (PLIE)

Purpose: To test an exercise program in older adults with mild cognitive impairment.

This Randomized, Controlled Trial Will Test The An Exercise Program In Older Adults With mild Cognitive Impairment (MCI) Who Live In The Community.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

People With Mild Cognitive Impairment (MCI) Have Memory Deficits But Remain Relatively Independent In Everyday Life. This Study Will Determine If Noninvasive Brain Stimulation Can Enhance Functioning In Specific Brain Regions And Networks, Increasing Participants' Ability To Benefit From Memory Rehabilitation.

Renew NCP-5 for MCI or Mild Alzheimer's

Purpose: To examine the efficacy and safety of the Renew NCP-5 device for the treatment of mild cognitive impairment or mild Alzheimer's disease.

This Phase III study Will Test The Renew NCP-5 Device For The Treatment Of Mild Cognitive Impairment (MCI) Or Alzheimer's Disease In Older Adults. The Device Is Approved By The U.S. Food And Drug Administration To Treat Chronic Stable Angina And To Help Improve The Dilation Of Blood Vessels, Oxygen Consumption, And Blood Flow In Healthy People.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

This Study Plans To Establish A Large Bank Of Blood, Cerebrospinal Fluid, Imaging, And Clinical Data To Be Used In Alzheimer's Disease Research.

Safety and Efficacy of Gantenerumab for Early Alzheimer's

Purpose: To evaluate the safety and efficacy of the investigational drug gantenerumab in people with early Alzheimer's disease.

This Phase III Clinical Trial Will Evaluate The Safety And Efficacy Of Gantenerumab In People With Early-stage Alzheimer's Disease. This Trial Is Similar To Gantenerumab For Early Alzheimer's Disease, But Recruiting In Different Locations.

Self-Management of Chronic Pain and Negative Emotions

Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.

This 24-week Pilot Study Will Test The Effects Of Problem Adaptation Therapy For Pain, Or PATH-Pain, In Helping To Reduce Negative Emotions And Pain In Older Adults Who Are Cognitively Normal Or Have Mild Cognitive Impairment.

Sensory Stimulation to Improve Brain Function (Overture Study)

Purpose: To study the effects of an auditory and visual sensory stimulation system on older adults with mild cognitive impairment and Alzheimer's disease.

The Overture Study Is A Phase I/II Clinical Trial To Study Safety, Adherence Rates, And Efficacy Of The Active GammaSense Stimulation System In Older Adults With Mild Cognitive Impairment (MCI) And Alzheimer's Disease. The Device Provides Noninvasive Auditory And Visual Sensory Stimulation To The Brain.

Stimulation to Undermine Dementia (STUD)

Purpose: To learn about the effects of weak electrical stimulation on brain functioning in people with mild cognitive impairment.

This Study Will Test The Effects Of Different Doses Of High-definition Transcranial Direct Current Stimulation, Or TDCS, For The Treatment Of People With Mild Cognitive Impairment (MCI).

Training for Optimal Routines in Mild Cognitive Impairment

Purpose: To test the effects of a behavioral intervention known as strategy training on the progression of disability in older adults with mild cognitive impairment.

This Study Will Test The Effects Of Strategy Training Compared To Enhanced Usual Care In Older Adults With Mild Cognitive Impairment (MCI). Researchers Are Investigating The Training As A Way To Slow The Emergence Of Disability And Keep People Engaged In Meaningful Daily Activities For As Long As Possible.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

This Study Will Investigate The Effect Of Transcranial Alternating Current Stimulation On Sleep And Cognitive Performance In Cognitively Normal Older Adults And In Individuals With Mild Cognitive Impairment (MCI).

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

This Study Will Explore The Use Of Transcranial Magnetic Stimulation (TMS) Integrated With Functional Magnetic Resonance Imaging (fMRI) For Diagnosing Preclinical Dementia. This Research Will Support Development Of A More Sensitive Diagnostic Tool For Dementia.

Transcranial Magnetic Stimulation for Apathy in MCI

Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.

In This Multi-phase Study, Researchers Are Investigating The Effects Of Transcranial Magnetic Stimulation (TMS) On Motivation, Memory, And Function In Older Veterans With Mild Memory Problems.

Transcutaneous Vagal Nerve Stimulation for MCI

Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.

This Study Will Test The Effects Of An Experimental Treatment, Transcutaneous Vagal Nerve Stimulation (tVNS), On Cognitive Performance And Memory In Older Adults With Mild Cognitive Impairment (MCI).

Using Connectomics to Characterize Risks for Alzheimer's Disease

Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.

This Observational Study Will Use Neuroimaging To Understand How The Connections In The Brain Change In Healthy Aging, Mild Cognitive Impairment (MCI), And Alzheimer's Disease In Order To Assess The Risk For Developing Alzheimer's.

Water-based Activity to Enhance Recall in Veterans (WATER-VET)

Purpose: To evaluate the feasibility of a water-based exercise program with cognitive training to improve memory in veterans with mild cognitive impairment.

This Study Will Evaluate The Feasibility Of A Water-based Exercise Program, Along With A Cognitive Training Intervention, To Improve Memory In Veterans With Amnestic (memory-related) Mild Cognitive Impairment (aMCI).