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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 66

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Aging-Well: Remote Monitoring for Adults at Risk for Alzheimer's Disease

Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.

Alzheimer Prevention Trials (APT) Webstudy

Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

BAN2401 for People with Early Alzheimer's Disease

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Energy for Amyloid Transformation in Alzheimer's Disease (BEAT-AD)

Purpose: To compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.

Brain Energy Metabolism and Sleep in Adults

Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

Calorie Restriction and Brain Function in Mild Cognitive Impairment

Purpose: To test the effects of intermittent calorie restriction in older adults with mild cognitive impairment who are overweight or obese.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

Cathodal Transcranial Direct Current Stimulation in MCI

Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.

Cleveland Clinic Healthy Brains Registry

Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment

Purpose: To evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss.

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

Exercise to Improve Cognitive Function in Veterans with MCI

Purpose: To assess the feasibility of a home-based exercise intervention to improve memory in veterans with mild cognitive impairment.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

High-Dose Vitamin D Supplements in Older Adults

Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

MRI-Guided Transcranial Magnetic Stimulation for MCI

Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

Mind-Body Skills and Physical Activity for MCI and Chronic Pain

Purpose: To adapt and examine a mind-body program, called Active Brains, to meet the needs of older adults with chronic pain and mild cognitive impairment.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

Neuroenergetic Adaptations in Alzheimer's Disease (PREPARE)

Purpose: To examine the relationship between brain energetics and risk for Alzheimer's disease.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nicotinamide Riboside for Mild Cognitive Impairment

Purpose: To test the effects of the supplement nicotinamide riboside on memory and brain blood flow in older adults with mild cognitive impairment.

OCTA in Mild Cognitive Impairment and Alzheimer's Disease

Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

Preventing Loss of Independence Through Exercise in Mild Cognitive Impairment (PLIE)

Purpose: To test an exercise program in older adults with mild cognitive impairment.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Renew NCP-5 for MCI or Mild Alzheimer's

Purpose: To examine the efficacy and safety of the Renew NCP-5 device for the treatment of mild cognitive impairment or mild Alzheimer's disease.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Safety and Efficacy of Gantenerumab for Early Alzheimer's

Purpose: To evaluate the safety and efficacy of the investigational drug gantenerumab in people with early Alzheimer's disease.

Self-Management of Chronic Pain and Negative Emotions

Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.

Sensory Stimulation to Improve Brain Function (Overture Study)

Purpose: To study the effects of an auditory and visual sensory stimulation system on older adults with mild cognitive impairment and Alzheimer's disease.

Stimulation to Undermine Dementia (STUD)

Purpose: To learn about the effects of weak electrical stimulation on brain functioning in people with mild cognitive impairment.

Targeting Verbal Short-Term Memory in Conjunction with tDCS in Neurodegenerative Disorders

Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.

Training for Optimal Routines in Mild Cognitive Impairment

Purpose: To test the effects of a behavioral intervention known as strategy training on the progression of disability in older adults with mild cognitive impairment.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

Transcranial Magnetic Stimulation for Apathy in MCI

Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.

Transcutaneous Vagal Nerve Stimulation for MCI

Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.

Using Connectomics to Characterize Risks for Alzheimer's Disease

Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.

Yoga and Meditation for Reducing Alzheimer's Risk in Women with MCI

Purpose: To test the effects of kundalini yoga and kirtan kriya yogic meditation, in comparison to memory training, in improving cognitive function, health, and mood in older adult women with mild cognitive impairment.