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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 61

[18F]MNI-798 for Imaging Tau in Alzheimer's Disease

Purpose: To evaluate changes in the protein tau in the brain of people at different stages of Alzheimer's disease and in healthy volunteers.

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

Behavioral Interventions for Mild Cognitive Impairment

Purpose: To compare the impact of a walking program, computer-based cognitive training program, and both programs in adults with mild cognitive impairment.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

Bisnorcymserine in Healthy Adult Volunteers

Purpose: To test the safety and action of the drug bisnorcymserine in healthy older volunteers.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Amyloid Retention After Sleep

Purpose: To compare the brain's removal of waste after a good night's sleep and after sleep deprivation.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

Citicoline for Age-Associated Memory Impairment

Purpose: To determine the effects of citicoline on cognitive performance in healthy adults with age-associated memory impairment.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

Cognitive Detection of Preclinical Alzheimer's: Validation Using Biomarkers

Purpose: To validate several novel cognitive tasks and correlate them with Alzheimer's disease biomarkers in people who are cogntitively normal or have mild cognitive impairment.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

Cognitive Training and Vortioxetine for Age-Related Cognitive Decline

Purpose: To examine the potential benefits of a combination of at-home cognitive training and Trintellix® on cognition in older adults with age-related cognitive decline.

Cognitive Training for Fall Prevention

Purpose: To test whether cognitive training can help decrease falls in older adults who are at risk for falls.

Cognitive Training to Improve Brain Function

Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

Dietary Flavanols and Dentate Gyrus Function

Purpose: To assess the effect of a cocoa-derived dietary supplement on cognitive function related to the dentate gyrus.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia (DIAN TU)

Purpose: To assess the safety, tolerability, and biomarker efficacy of gantenerumab and solanezumab in individuals who have a genetic mutation for autosomal-dominant Alzheimer's disease.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

E2027 in Healthy Subjects

Purpose: To evaluate the safety, tolerability, and pharmacodynamics of E2027 in healthy participants.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

GeneMatch

Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Human Brain Antioxidants During Oxidative Stress

Purpose: To evaluate the level of two antioxidants in the brain as humans with and without Alzheimer's disease get older.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

JNJ-54861911 in Older Adults at Risk for Alzheimer's (EARLY)

Purpose: To evaluate whether an experimental drug, JNJ-54861911, slows cognitive decline in older adults who are at risk for developing Alzheimer's.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

Mediterranean Diet to Prevent Cognitive Decline

Purpose: To evaluate the feasibility of a Mediterranean diet in older adults.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

MIND Diet to Prevent Cognitive Decline

Purpose: To test the effects of the MIND diet on cognitive decline in seniors without cognitive impairment.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Mindfulness-Based Stress Reduction, Health Education, and Exercise

Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

OCTA in Mild Cognitive Impairment and Alzheimer's Disease

Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Optimizing Postoperative Cognition in the Elderly

Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

Pomegranate Juice and Memory

Purpose: To determine if drinking pomegranate juice benefits cognitive abilities in middle-aged and older adults without dementia.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

TAK-071 for Mild Cognitive Impairment and Mild Alzheimer's Disease

Purpose: To assess the safety, tolerability, and pharmacokinetics of the experimental drug TAK-071 for mild cognitive impairment and mild Alzheimer's disease.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.