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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 67

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.


Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

Optimizing Postoperative Cognition in the Elderly

Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.

Cognitive Detection of Preclinical Alzheimer's: Validation Using Biomarkers

Purpose: To validate several novel cognitive tasks and correlate them with Alzheimer's disease biomarkers in people who are cogntitively normal or have mild cognitive impairment.

Mindfulness-Based Stress Reduction, Health Education, and Exercise

Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

E2027 in Healthy Subjects

Purpose: To evaluate the safety, tolerability, and pharmacodynamics of E2027 in healthy participants.

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

Behavioral Interventions for Mild Cognitive Impairment

Purpose: To compare the impact of a walking program, computer-based cognitive training program, and both programs in adults with mild cognitive impairment.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Cognitive Training and Vortioxetine for Age-Related Cognitive Decline

Purpose: To examine the potential benefits of a combination of at-home cognitive training and Trintellix® on cognition in older adults with age-related cognitive decline.

Citicoline for Age-Associated Memory Impairment

Purpose: To determine the effects of citicoline on cognitive performance in healthy adults with age-associated memory impairment.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Methylation Diet and Lifestyle Changes in Older Adult Men

Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.


Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

Cognitive Training to Improve Brain Function

Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

Program for African American Cognition and Exercise (PAACE)

Purpose: To develop and evaluate a program to increase physical activity and improve cognitive function in African-American older adults who are sedentary.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

Internet-Based Conversational Engagement for Socially Isolated Older Adults (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face Web-based conversations could improve cognitive function in older adults who are socially isolated.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

Bisnorcymserine in Healthy Adult Volunteers

Purpose: To test the safety and action of the drug bisnorcymserine in healthy older volunteers.

COR388 in Healthy Volunteers and People with Alzheimer's

Purpose: To assess the safety and tolerability of the investigational drug COR388 in healthy older adults and those with Alzheimer's disease.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

Cognitive Training for Fall Prevention

Purpose: To test whether cognitive training can help decrease falls in older adults who are at risk for falls.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.