Find Alzheimer’s Disease and Related Clinical Trials
Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.
Results found: 100
Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.
Purpose: To test whether the investigational drug AGB101 can reduce abnormal hyperfunctional activity in the hippocampus in healthy adults who are APOE 4 carriers.
Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.
Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.
Purpose: To collect and study data from people with frontotemporal lobar degeneration and their family members to understand changes in brain function and biomarkers as the disease progresses.
Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.
Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.
Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.
Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.
Purpose: To assess the safety, tolerability, and pharmacokinetics of the investigational drug J147 in healthy young and older adults.
Purpose: To investigate the effects of combined cognitive training and transcranial direct current stimulation on cognition and brain function in older adults.
Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.
Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.
Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.
Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.
Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.
Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.
Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.
Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).
Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.
Purpose: To test whether computer-based brain training activities can promote cognitive, emotional, and physical health in older adult caregivers of a spouse or significant other with dementia.
Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.
Purpose: To test a computerized screening tool to detect early cognitive decline in older adults during their doctor's visits.
Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.
Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.
Purpose: To test an online group intervention for decreasing caregivers' grief, depression, anxiety, and conflict after their family member transitions to a long-term care facility.
Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.
Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.
Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.
Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.
Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).
Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.
Purpose: To evaluate a prototype online aid designed to help people think through whether or not to undergo genetic testing for late-onset Alzheimer's disease.
Purpose: To understand and enhance the detection of exercise effects on hippocampal network function, learning and memory in older adults.
Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.
Purpose: To learn more about biomarkers and their relationship to aging.
Purpose: To learn more about the genetic causes of movement disorders and dementias.
Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.
Purpose: To test an iPad application for measuring neurological functioning.
Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.
Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.
Purpose: To develop and evaluate an in-home supportive technology to help alleviate anxiety, burden, and loneliness in family caregivers of people with Alzheimer's disease, related dementias, or mild cognitive impairment.
Purpose: To develop and evaluate in-home assistive technology to alleviate anxiety, burden, and loneliness in caregivers of people with Alzheimer's disease and frontotemporal dementia.
Purpose: To test an in-home training program for African American caregivers of people living with Alzheimers disease or related dementia to reduce caregiver burden and stress and improve coping skills.
Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.
strong>Purpose: To test an online care planning tool designed to provide individualized information to better serve the diverse needs of caregivers and care recipients living with Alzheimer's disease or a related dementia.
Purpose: To test cognitive behavioral therapy for insomnia to improve the sleep of community-dwelling persons living with dementia and their caregivers.
Purpose: To examine whether increasing social interaction through face-to-face web-based conversations could improve cognitive function in older adults who are socially isolated.
Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.
Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.
Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.
Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.
Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.
Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.
Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.
Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.
Purpose: To study imaging differences between children of parents with and without late-onset Alzheimer's disease.
Purpose: To examine the impact of mind-body interventions on neurocognitive and emotional functioning in older adults.
Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.
Purpose: To assess telephone-based mindfulness training to alleviate caregiver burden for African American rural caregivers of people with moderate to severe dementia.
Purpose: To test a mobile-based web intervention designed to reduce dementia caregiver distress and improve overall well-being.
Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.
Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.
Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.
Purpose: To examine the safety, tolerability, and pharmacokinetics of single and multiple doses of the investigational drug NNI-362 in healthy older adults.
Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.
Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.
Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.
Purpose: To evaluate an interactive, online workshop designed to support isolated dementia caregivers in rural areas and reduce caregiver stress and depression.
Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.
Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.
Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.
Purpose: To demonstrate the feasibility of a larger trial to test cognitive training for reducing mild cognitive impairment and dementia in older adults with normal cognition.
Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.
Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.
Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.
Purpose: To evaluate the safety and tolerability of PNT001 in healthy adults.
Purpose: To evaluate the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.
Purpose: To test the effects of cognitive behavioral training for insomnia (CBT-I) in older adults with symptoms of insomnia.
Purpose: To evaluate the use of SmartPrompt, a smartphone-based electronic reminder aid that is designed to help older adults with dementia perform daily tasks.
Purpose: To evaluate the efficacy of a novel cognitive training approach in older adults using simulated games.
Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.
Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.
Purpose: To better understand the role of the immune response, including inflammation, in Parkinson's disease (PD) and Alzheimer's disease (AD).
Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.
Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.
Purpose: To test a telephone-based behavioral intervention designed to reduce anxiety and associated psychological distress in dementia caregivers.
Purpose: To study the use of a videoconference-based system known as Support via Technology: Living and Learning with Advancing Alzheimer's Disease and Related Dementias to provide education and support to family caregivers, as well as the person with dementia.
Purpose: To test a distance-learning training program for family caregivers of people with Alzheimer's or TBI in reducing care-resistant behaviors.
Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.
Purpose: To test the effects of noninvasive stimulation on the brain to determine whether it can reset disconnections to stabilize or improve memory and cognitive function.
Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.
Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.
Purpose: To test a noninvasive brain stimulation therapy to improve cognition, including memory, in older adults and people with amnestic mild cognitive impairment due to Alzheimer's disease.
Purpose: To test the effects of repetitive transcranial magnetic stimulation and working memory training on improving cognitive function.
Purpose: To develop and test a mobile health application, the CARE-well App, that will provide resources to support informal dementia caregivers.
Purpose: To develop a trial-ready cohort for Alzheimer's disease prevention clinical trials.
Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.
Purpose:>/strong> To test the combined effects of visual cognitive training games and aerobic exercise to improve cognition in older adults with mild cognitive decline and who are at-risk for developing Alzheimer's disease.