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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 74

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

The Goal Of This Observational Study Is To Identify Reliable Methods For Tracking The Progression Of Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), And Oligosymptomatic/variant Progressive Supranuclear Palsy (o/vPSP) Over Time.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

This Study Aims To Better Understand The Relationship Between Variations Of The APOE Gene And Metabolism By Testing Metabolic Rate At Rest And During A Cognitive Challenge In Healthy Adults. Results May Help Investigators Identify New Targets For The Prevention And Treatment Of Cognitive Decline And Dementia.

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

This Study Will Examine The Impact Of Cognitive Training And Aerobic Exercise In Sedentary Older Adults, Specifically Older Adults At Risk For Mobility Disability. Participants Will Be Randomly Assigned To Either A Group That Does Cognitive Training Alone Or A Group That Does Combined Cognitive Training And Aerobic Exercise.

Alzheimer Prevention Trials (APT) Webstudy

Purpose:To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

The Alzheimer Prevention Trials (APT) Webstudy Is An Online Registry Designed To Accelerate Enrollment For Alzheimer's Disease Clinical Trials By Identifying And Tracking Individuals Who May Be At Higher Risk For Developing Alzheimer's dementia.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

This Study Will Compare Two Intervention Strategies For Reducing Emotional And Cardiovascular Disease Risk In Alzheimer's Caregivers: Behavioral Activation Therapy And Support And Information.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

The Purpose Of This Observational Study Is To Determine The Relationships Among Clinical, Cognitive, Imaging, Genetic, And Biomarker Characteristics Of The Entire Spectrum Of Alzheimer's Disease As It Progresses From A Preclinical Stage To Very Mild Symptoms To Mild Cognitive Impairment (MCI) To Dementia. Participants Sought Include Those With Normal Cognition, MCI, Or Mild Alzheimer's Dementia (currently Recruiting Non-Caucasian Participants Only For The Normal Cognition Group).

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

The Alzheimer's Prevention Registry Is A National Registry Of Individuals Age 18 And Older Who Are Interested In Learning About And Possibly Participating In Alzheimer's Prevention Clinical Studies And Trials. The Registry Will Collect Contact And Demographic Information, Provide Information About The Latest News And Advances In Alzheimer's Prevention Research, And Inform Enrollees About Research Studies In Their Community.

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

This Study Will Test The Effects Of Different Kinds Of Auditory Training On Hearing Function In Healthy Adults. Hearing Loss Has Been Associated With Cognitive Decline And Decreased Quality Of Life, And Researchers Are Exploring Whether Such Auditory Training Could Compensate For And/or Reverse Hearing Deficits In Older Adults.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

The Purpose Of This Study Is To Evaluate A Brain Fitness Intervention For improving Cognitive Health In Middle-aged And Older Adults.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

This Study Will Evaluate The Safety And Tolerability Of BIIB076 In Cognitively Normal Older Adults And Older Adults With Alzheimer's Disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

This Phase II Study Will Test Whether Lowering Blood Pressure Using Antihypertensive Drugs Alters Brain Pulsatility, A Measure Of Blood Flow, And Reduces Amyloid-beta Accumulation In The Brains Of Older Adults.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Traumatic Brain Injury (TBI) And Post Traumatic Stress Disorder (PTSD) Are Common Combat-related Problems And May Be Associated With A Greater Risk Of Alzheimer's Disease. This Study Will Examine The Possible Connections Between TBI And PTSD, And The Signs And Symptoms Of Alzheimer's In Vietnam War Veterans As They Age.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

The Purpose Of The Online Brain Health Registry Is To Recruit And Observe People Who Are Interested In Promoting Healthy Brain Function Through The Prevention Of Brain Diseases, Disorders, And Injuries In Adults. Participation Involves Answering Questions About Your Health, Lifestyle, And Medical History And Taking Online Brain Tests. Researchers Hope To Build A Large Pool Of Potential Participants For Clinical Trials, Reducing The Time And Cost Of Research.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

This Clinical Trial Will Test Whether Two Investigational Drugs, CAD106 And CNP520, Administered Separately, Can Prevent Or Delay Alzheimer's Disease Symptoms In People At High Risk Of Developing Dementia Based On Their Age And Genetic Status.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

The Generation 2 Study Will Test The Safety And Effects Of The Investigational Drug CNP520 in Cognitively Normal Older Adults Who Are At risk Of Developing Dementia Based On Their Age, Genetic Status, And Brain Amyloid Levels.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

This Clinical Trial Will Use Positron Emission Tomography (PET) Scanning To Measure The Clearance Of Waste From The Brain Via Cerebrospinal Fluid. The Objective Is To Determine The Role Of Impaired Clearance In The Buildup Of The Amyloid Protein In The Aging Brain And Risk For Alzheimer's Disease. A Harmful Form Of Amyloid Is Seen In The Brains Of People With Alzheimer's.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

This Study Will Evaluate The Effects Of Cognitive Rehabilitation And Transcranial Electrical Stimulation (TES) On Cognitive Abilities In Adults Who Are Cognitively Normal Or Experiencing Cognitive Dysfunction.

Cognitive Training to Improve Brain Function

Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.

In This Study, Researchers Will Measure The Potential For Cognitive Training To Improve Brain Function In Older Adults With And Without A History Of Mild Cognitive Impairment (MCI).

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

This Study Examines The Impact On Older Adults Of Learning The Results Of Amyloid Brain Imaging, Which Can Indicate Risk For Alzheimer's Disease. 

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

This Interview-based Study Compares Alzheimer's Disease caregiving In The United States And Mexico. The Goal Is To Identify Cross-cultural Differences In Order To Identify Strategies That May reduce The Burden Of The Disease On Family Caregivers. 

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

This Study Will examine The Feasibility Of Biochemical Assays, Genetic Testing, And Cognitive And Lifestyle Assessments In The Diagnosis Of Alzheimer's Disease, Mild Cognitive Impairment, And Other Neurodegenerative Diseases. The Study Also Aims To Assess Changes In Biological, Lifestyle, And Cognitive Assessments Collected From Individuals Over Time.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

The Goal Of This Project Is To Identify Whether Carrying The APOE 4 Allele, the Strongest Genetic Risk Factor For Developing Alzheimer's Disease, Is Associated With Reduced Delivery Of DHA, An Omega-3 Fatty Acid, To The Brain in Cognitively Healthy Older Individuals. This Information Will Help Identify The Target Population That Could Benefit From DHA Supplementation To Prevent Cognitive Decline.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

This Study Will Examine The Effect Of Different Types Of Meals On Cognitive Function And Alzheimer's Biomarkers In Healthy Older Adults With And Without The APOE E4 Genotype. 

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

The Study Will Explore The Effect Of Dietary Ketosis (a High-fat, Low-carbohydrate Diet Also Known As The Ketogenic Diet) On Adults With Early-stage Memory Loss And Metabolic Syndrome.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

The Purpose Of This Study Is To Identify Potential Biomarkers That May Predict The Development Of Alzheimer's Disease In People Who Carry An Alzheimer's Mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

This Study Will Determine If The Alzheimer's Disease Drug Memantine Hydrochloride Can Improve Learning And Memory In Adolescents And Young Adults With Down Syndrome.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

This Study Will Test An Education And Skills-based Training Program For People With Early-stage Memory Loss Or Dementia And Their Care Partners. The Training Is Designed To Reduce Stress And Distress, And Increase Well-being And Quality Of Life.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

This Study Will Examine The Sensitivity Of Functional Magnetic Resonance Imaging (fMRI) To Detect Brain Changes In Healthy Older Adults At Genetic Risk For Alzheimer's Disease Who Take The Drug Donepezil (Aricept). Participants With A Family History Of Alzheimer's Are Eligible For This Study. Participants Without A Family History Of Alzheimer's Can Be enrolled To Serve As A Control Group.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

This Study Is Recruiting Older Adults Who Are Cognitively Healthy But Physically Inactive to Participate In An Intervention Comparing Aerobic Exercise And Flexibility Exercise And Their Effects On Memory And Brain Function.

GeneMatch

Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

The GeneMatch Program, Part Of The Alzheimer's Prevention Registry, Aims To Identify People Interested In Participating In Research Studies Or Clinical Trials Based In Part On Their Genetic Background. GeneMatch Will Collect Genetic Information From Participants Which May Be Used To Match Them To Studies. Participants Are Under No Obligation To Pursue These Study Opportunities.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

This Long-term Study Will Help Researchers Learn More About Biomarkerssubstances In Human Blood And Tissuesand Their Relationship To Aging. The Goal Is To Find Ways To Improve Quality Of Life In Old Age.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

In This Observational Study, Scientists Will Examine The Genes Of Families With A History Of Movement Disorders (such As Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Ataxia, Corticobasal Degeneration, Dystonia, Essential Tremor, And Huntington's Disease) And Dementias (such As Alzheimer's Disease, Lewy Body Dementia, And Frontotemporal Dementia) To Try To Find a Genetic Cause Of These Disorders. People With Any Movement Disorder Or Dementia And Their Family Members Are Invited To Participate.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

This Study Will Test The Ability Of The Radioactive Tracer 11C-ER176 To Stick To Parts Of The Brain Where There Is Inflammation. Past Studies Have Shown That Inflammation Is Present In The Brains Of People With Alzheimer's Disease.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

This Study Uses Mobile Health Devices To Help Physically Inactive, Cognitively Normal Older Adults Walk, With The Aim Of Preserving Cognitive Function.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

This Observational Study Will Track Cognitive And Neural Biomarkers In People Younger Than 50 Who Are Overweight Or Obese And Have Metabolic Risk Factors Associated With Cognitive Decline Later In Life.

Internet-Based Conversational Engagement for Socially Isolated Older Adults (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face Web-based conversations could improve cognitive function in older adults who are socially isolated.

This Study Will Test The Effects Of Regular Web-based Conversations On Cognitive Function In Adults Over 80 Who Are Socially Isolated.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

This Trial Will Test The Effects Of 12 Months Of Walking exercise On Cognitive Performance, Brain Structure And Function, And Other Biological Measures In Older Adults Who Are Cognitively Normal.

LY3372993 in Healthy Participants and People with Alzheimer's

Purpose: To evaluate the safety and tolerability of the investigational drug LY3372993 in healthy adults and older adults with Alzheimer's disease.

This Phase I Study Will Test The Safety And Tolerability Of The Investigational Drug LY3372993 In Healthy Adults And Older Adults With Alzheimer's Disease. 

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

This Study Will Examine The Effects Of Exercise And Healthy Living Education On Brain Health, Cognition, And Physical Function In Older Adults With Cognitive Concerns.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Is A 2-year Observational Study Designed To Look At Disease Progression In Adults With Early-onset Alzheimer's Disease. Researchers Are Also Recruiting Cognitively Normal Volunteers For A 1-year Comparison.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

The Purpose Of This Study Is To Learn About Thinking And Behavior In Families In Which One Or More Relatives Has A Genetic Mutation Associated With Frontotemporal Dementia.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Obesity Is Associated With A Higher Risk Of Health Problems, Including Heart Disease, Hypertension, And Diabetes, And May Be A Risk Factor For Cognitive Decline And Dementia. This Study Will Test The Effects Of A Mediterranean Diet And Caloric Restriction To Promote Weight Loss And Improve Cognitive Function In Obese Older Adults.

Methylation Diet and Lifestyle Changes in Older Adult Men

Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.

This Study Will Evaluate A 9-week Diet And Lifestyle Intervention In Healthy Older Adult Men To Test whether Short-term Changes Can Affect DNA Methylation. Methylation Is an Epigenetic Change That Affects The Way Genes Function And Has Been Associated With Dementia And Other Conditions, Including Diabetes And Cancer. 

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

This Observational Study Will Examine Changes In brain-region Size, Shape, And Activity That Occur In Women With Breast Cancer And How Those Changes Relate To The Development Of Mild Cognitive Impairment. Three Groups Will Be Compared: Women With Breast Cancer Who Will Undergo Hormonal Therapy With Or Without Chemotherapy, Women With Breast Cancer Who Will Undergo No Therapy Or Radiation Therapy, And Healthy Female Volunteers.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

MindCrowd Is A Web-based Memory Study Designed To Analyze How Genetics Influences Memory. Participants Age 18 Or Older Are Invited To Take A 10-minute Online Test. For More Information, Visit www.mindcrowd.org.

Mindfulness-Based Stress Reduction, Health Education, and Exercise

Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.

This Study Will Examine The Effects On Age-related Cognitive Decline Of Mindfulness-based Stress Reduction (MBSR), Aerobic Exercise, And Their Combination, Compared With A Health Discussion Group.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

The Modified Story Memory Technique (mSMT) Cognitive Retraining Program Has Been Shown To Improve new Learning And Memory Function in Individuals With Multiple Sclerosis And Traumatic Brain Injury. This Study Will Measure The Effects Of MSMT In Cognitively Healthy Older Adults And Adults With Mild Cognitive Impairment. Researchers Will Determine whether Engaging In MSMT Can Enhance Memory And Learning Ability.

Multicultural Healthy Diet to Reduce Cognitive Decline

Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.

This 18-month Trial Is Designed To Investigate Whether The Multicultural Healthy Diet, An Anti-inflammatory Diet Tailored To A Multicultural Population, Can Improve Cognitive Functioning In Urban-dwelling Adults.

Multidimensional Behavioral Intervention for Adults with Cognitive Concerns (BBLite)

Purpose: To promote use of compensation strategies, organization systems, and brain health activities in older adults with concerns about their memory and cognitive function.

This Study Will Test The Effectiveness Of A Multidimensional intervention to Enhance skills Related To Everyday Activities In Adults With Concerns About Their Memory Or Cognitive Function, As Well As engagement In Healthy Lifestyle Activities To Further Promote Brain Health.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

This Study Will Test A 10-week Intervention Designed To Promote Use Of Compensation Skills And Organization Systems and Increased Engagement With Brain Health Activities In Older Adults With Subjective Cognitive Concerns.

Multidirectional Yoga for Cognition

Purpose: To explore the effects of a new yoga intervention on cognitive function in older adults.

This Study Will Test A Yoga Intervention in Cognitively Normal Older Adults To Gauge Its Effects On Cognitive Function And Associated Movements.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

This Phase II Trial Will Explore The Effects Of Music Training On Central Auditory Processing, Cognition, And Everyday Function Among Older Adults With And Without Mild Cognitive Impairment.

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

This Phase 1 Trial Will Test An Experimental Drug, NDX-1017, in Healthy Adults And People With Mild Alzheimer's Disease To Evaluate Safety, Dosing, And Action Of The Drug.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

This Study Will Evaluate The Effect Of Icosapent Ethyl, A Form Of An Omega-3 Fatty Acid found In Fish Oil, On Cognitive Performance And Alzheimer's-related Biomarkers In Cognitively Healthy Veterans At Increased Risk For Alzheimer's Disease.

Optimizing Postoperative Cognition in the Elderly

Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.

Investigators Will Compare Brain-wave Patterns In Older Patients Who Have Memory And Thinking Problems After Surgery With Brain-wave Patterns In Patients Without Such Problems.

Performing Arts for Alzheimer's Dementia Caregivers

Purpose: To examine whether a performing arts class will improve the well-being of primary unpaid caregivers of people with Alzheimer's dementia.

This Study Will Examine The Effect Of A Performing Arts Class On Improving The Well-being Of Caregivers Of Older Adults With Alzheimer's Dementia.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

This Research Will Examine The Effect On Cognition Of Increasing Physical Activity Using A Body-worn Sensor. Older Adults Will Be Asked To Increase Physical Activity For 12 Weeks While Wearing A Sensor Attached To A Belt That Will Monitor Activity.

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

This Study Will Examine How Different Types Of Training Activity Affect Older Adults' Cognitive Function, Brain Structure, Biomarkers Of Brain Health And Cognition, And Physical Function. In Addition, The Study Will Assess How An Individual's Cognitive And Physical Characteristics Influence Their Responsiveness To Each Type Of Training Activity.

Program for African American Cognition and Exercise (PAACE)

Purpose: To develop and evaluate a program to increase physical activity and improve cognitive function in African-American older adults who are sedentary.

The PAACE Study Is Designed To Develop A Physical Activity Program For African-American Older Adults Who Are Sedentary To Improve Cognition And Brain Health.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

People With Mild Cognitive Impairment (MCI) Have Memory Deficits But Remain Relatively Independent In Everyday Life. This Study Will Determine If Noninvasive Brain Stimulation Can Enhance Functioning In Specific Brain Regions And Networks, Increasing Participants' Ability To Benefit From Memory Rehabilitation.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Researchers Will Use Magnetic Resonance Imaging (MRI) To Investigate Brain Function And Connections In Healthy Adults. This Might Help People With Brain Diseases In The Future.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

This Study Will Explore The Effect Of Consultation Sessions On Reducing Distress And Strain In Family Caregivers Who Have Transitioned A Cognitively Impaired Relative To Long-term Care.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

This Study Plans To Establish A Large Bank Of Blood, Cerebrospinal Fluid, Imaging, And Clinical Data To Be Used In Alzheimer's Disease Research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

This Phase I study Will Investigate The Role Of The Nicotinic System In The Brain, A Subset Of The Cholinergic System, On Memory And Thinking And Healthy Aging By Using Stimulants And Blockers To Examine Brain Activation Patterns.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

This Study Of Aging And The Brain Is Looking For Healthy Older Adults To Participate In Brain Imaging, Genetic Testing, Memory Testing, And Analysis Of Proteins In The Blood And Spinal Fluid. The Goal Is To Develop Biological Markers To Aid In Better Understanding, Early Detection, And Treatment Of Alzheimer’s Disease.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

This Study Will Test The Effects Of Strawberry Powder On Cognition And Mobility In Cognitively Normal Obese Older Adults.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

This Study Will Use The New Radioactive Tracer 18F-MK-6240 In Positron Emission Tomography (PET) Scanning To Detect Tau Pathology In Older Adults Who Are Cognitively Healthy And Mildly Cognitively Impaired.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

This Study Is Testing An Internet-based Education Program For Caregivers Of People With Alzheimer's Or Another Dementia.

Training to Reduce Care-Resistant Behaviors in Alzheimer's and TBI (NeuroNS-Care)

Purpose: To test a distance-learning training program for family caregivers of people with Alzheimer's or TBI in reducing care-resistant behaviors.

This Study Will Test The Effectiveness Of An Internet-based Distance-learning Program In Reducing Care-resistant Behaviors, Including Agitation, Aggression, And Irritability, In People With Alzheimer's Disease Or Traumatic Brain Injury (TBI).

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

This Study Will Investigate The Effect Of Transcranial Alternating Current Stimulation On Sleep And Cognitive Performance In Cognitively Normal Older Adults And In Individuals With Mild Cognitive Impairment (MCI).

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

This Study Will Explore The Use Of Transcranial Magnetic Stimulation (TMS) Integrated With Functional Magnetic Resonance Imaging (fMRI) For Diagnosing Preclinical Dementia. This Research Will Support Development Of A More Sensitive Diagnostic Tool For Dementia.

Transcranial Magnetic Stimulation for Apathy in MCI

Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.

In This Multi-phase Study, Researchers Are Investigating The Effects Of Transcranial Magnetic Stimulation (TMS) On Motivation, Memory, And Function In Older Veterans With Mild Memory Problems.

VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

The Purpose Of This Study Is To Study The Effects Of An Education And Skill-building Intervention On Family Caregivers Of Veterans With Dementia.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.

This Phase I Trial Of The Experimental Drug VU319, Developed To Improve Cognitive Function In People With Alzheimers, Will Study Its Effects in Healthy Adults.