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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 103

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

AGB101 for Preclinical Alzheimer's Disease

Purpose: To test whether the investigational drug AGB101 can reduce abnormal hyperfunctional activity in the hippocampus in healthy adults who are APOE 4 carriers.

AL001 for Frontotemporal Dementia in Healthy Volunteers and People with FTD

Purpose: To assess the safety, tolerability, and behavior of the drug AL001 in healthy adult volunteers and people with frontotemporal dementia and the granulin mutation.

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

Aging-Well: Remote Monitoring for Adults at Risk for Alzheimer's Disease

Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.

Alzheimer Prevention Trials (APT) Webstudy

Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

Assessing J147 for Alzheimer's in Healthy Volunteers

Purpose: To assess the safety, tolerability, and pharmacokinetics of the investigational drug J147 in healthy young and older adults.

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

Augmenting Cognitive Training in Older Adults (ACT)

Purpose: To investigate the effects of combined cognitive training and transcranial direct current stimulation on cognition and brain function in older adults.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Energy Metabolism and Sleep in Adults

Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.

Brain Enhancement Training Toward Elders' Resilience to Aging

Purpose: To test an experimental software program designed to improve cognitive function.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

Brain Safe: Reducing Exposure to Drugs Linked to Alzheimer's

Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

Cleveland Clinic Healthy Brains Registry

Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

Cognitive Training for Older Caregivers

Purpose: To test whether computer-based brain training activities can promote cognitive, emotional, and physical health in older adult caregivers of a spouse or significant other with dementia.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

Computerized Screening Tool for Cognitive Decline

Purpose: To test a computerized screening tool to detect early cognitive decline in older adults during their doctor's visits.

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention

Purpose: To test an online group intervention for decreasing caregivers' grief, depression, anxiety, and conflict after their family member transitions to a long-term care facility.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders

Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)

Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.

Evaluation of an Online Decision Aid for Alzheimer's Genetic Testing

Purpose: To evaluate a prototype online aid designed to help people think through whether or not to undergo genetic testing for late-onset Alzheimer's disease.

Exercise Effects on Brain Health and Learning

Purpose: To understand and enhance the detection of exercise effects on hippocampal network function, learning ,and memory in older adults.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

High-Dose Vitamin D Supplements in Older Adults

Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

Improving Well-Being for Older Adult Family Dementia Caregivers

Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.

In-Home Technology for Dementia Caregivers

Purpose: To develop and evaluate in-home assistive technology to alleviate anxiety, burden, and loneliness in caregivers of people with Alzheimer's disease and frontotemporal dementia.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

Internet-Based Conversational Engagement Clinical Trial (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face web-based conversations could improve cognitive function in older adults who are socially isolated.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

Longitudinal Innate Immunity and Aging Study (LIIA)

Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.

MRI and PET Biomarkers for Cognitive Decline in Older Adults

Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.

MRI-Guided Transcranial Magnetic Stimulation for MCI

Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

Mind-Body Interventions for Healthy Aging

Purpose: To examine the impact of mind-body interventions on neurocognitive and emotional functioning in older adults.


Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Mindfulness Training for African American Dementia Caregivers

Purpose: To assess telephone-based mindfulness training to alleviate caregiver burden for African American rural caregivers of people with moderate to severe dementia.

Mindfulness Training for Caregivers of People with Dementia

Purpose: To test mindfulness-based stress reduction training on caregiver well-being, sleep, and physiological responses to stress.

Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being

Purpose: To test a mobile-based web intervention designed to reduce dementia caregiver distress and improve overall well-being.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

NNI-362 in Healthy Older Adults

Purpose: To examine the safety, tolerability, and pharmacokinetics of single and multiple doses of the investigational drug NNI-362 in healthy older adults.

Neuroenergetic Adaptations in Alzheimer's Disease (PREPARE)

Purpose: To examine the relationship between brain energetics and risk for Alzheimer's disease.

Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD)

Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.

OCTA in Mild Cognitive Impairment and Alzheimer's Disease

Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

PET Imaging of Neuroinflammation in Neurodegenerative Diseases

Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.

Physical Activity and Alzheimer's Disease (PAAD-2)

Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

Preventing Alzheimer's Disease with Cognitive Training (PACT)

Purpose: To demonstrate the feasibility of a larger trial to test cognitive training for reducing mild cognitive impairment and dementia in older adults with normal cognition.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

Safety and Tolerability of PNT001 in Healthy Adults

Purpose: To evaluate the safety and tolerability of PNT001 in healthy adults.

Sensory Enrichment for Older Adults

Purpose: To evaluate the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.

Sleep Intervention to Enhance Cognitive Status and Reduce Beta-Amyloid (SIESTA)

Purpose: To test the effects of cognitive behavioral training for insomnia (CBT-I) in older adults with symptoms of insomnia.

Social Dancing Movement Intervention for Memory Enhancement (MIME)

Purpose: To test social dancing as a method to prevent or delay cognitive decline in older adults at high risk for Alzheimer's disease and related dementias.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

Strategic Training to Optimize Neurocognitive Functions in Older Adults

Purpose: To evaluate the efficacy of a novel cognitive training approach in older adults using simulated games.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

Study to Evaluate Amyloid in Blood and Imaging Related to Dementia (SEABIRD)

Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.

Tau Imaging with an [18F]MK-6240 Tracer

Purpose: To use the tau tracer [18F]MK-6240 to image the brains of individuals from families with a known autosomal dominant Alzheimer's disease mutation.

Tau Kinetics in Healthy Aging and Alzheimer's Disease

Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

Testing RO7126209 for Alzheimer's Disease in Healthy Volunteers

Purpose: To investigate the safety, tolerability, and pharmacokinetics of the investigational drug RO7126209 in healthy volunteers.

Training to Reduce Care-Resistant Behaviors in Alzheimer's and TBI (NeuroNS-Care)

Purpose: To test a distance-learning training program for family caregivers of people with Alzheimer's or TBI in reducing care-resistant behaviors.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

Transcranial Magnetic Stimulation for Apathy in MCI

Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.

Transcranial Magnetic Stimulation to Increase Executive Function in Older Adults

Purpose: To test the effects of repetitive transcranial magnetic stimulation and working memory training on improving cognitive function.

Trial-Ready Cohort for the Prevention of Alzheimer's Dementia (TRC-PAD)

Purpose: To develop a trial-ready cohort for Alzheimer's disease prevention clinical trials.

U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER)

Purpose: To test the effects of lifestyle changes on memory loss and thinking in older Americans who are at risk for memory loss.

Using Connectomics to Characterize Risks for Alzheimer's Disease

Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.