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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 16

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Combining Aerobic Exercise And Cognitive Training, This Study Will Compare The Effects Of Cycling And Cognitive Training Alone And Together in Older Adults With Mild Cognitive Impairment (MCI).

Brain Connections, Self-Care, and Blood Pressure in African Americans with Memory Problems

Purpose:To evaluate a dietary and mindfulness intervention to decrease blood pressure and improve brain function in black and African-American older adults with high blood pressure and early Alzheimer's disease or a related dementia.

This Study Is Designed To Help Adapt A Previously Tested Intervention Involving The DASH (Dietary Approaches To Stop Hypertension) Diet And Mindfulness Techniques For Black And African American Older Adults With High Blood Pressure And Early Alzheimer's Disease Or A Related Dementia.

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

This Study Will Determine The Impact Of Two Interventions In People With Early Memory Problems. First, It Will Test the Clinical Benefits Of Curcumin, A Compound Isolated From turmeric Root, A component Of Indian Curry Spices That Has Been Found To Inhibit Several Potential Pathways In Alzheimer's Disease. Second, It Will determine The Effect Of adding A Yoga-based physical Exercise Program.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Physical Inactivity, High Blood Pressure, And High Cholesterol Levels Are Risk Factors For Alzheimer's Disease And Vascular Dementia; However, These Risk Factors Are Modifiable With Lifestyle Changes And Medications. This Study Will Test The Effects Of Aerobic Exercise And Vascular Risk Reduction On Cognitive Performance In Older Adults Who Are At Risk For Alzheimer's Disease.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

This Study Is Recruiting Older Adults Who Are Cognitively Healthy But Physically Inactive to Participate In An Intervention Comparing Aerobic Exercise And Flexibility Exercise And Their Effects On Memory And Brain Function.

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

This Study Evaluates The Effects Of Physical Exercise On Cognition, Functional Status, Brain Atrophy, Blood Flow, And Cerebrospinal Fluid Biomarkers Of Alzheimer's Disease In Adults With A Mild Memory Impairment. Half Of Participants Will Participate In A Stretching-balance-range Of Motion Exercise Program, While The Other Half Will Participate In A Moderate- To High-intensity Aerobic Training Program.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

This Study Uses Mobile Health Devices To Help Physically Inactive, Cognitively Normal Older Adults Walk, With The Aim Of Preserving Cognitive Function.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

This Trial Will Test The Effects Of 12 Months Of Walking exercise On Cognitive Performance, Brain Structure And Function, And Other Biological Measures In Older Adults Who Are Cognitively Normal.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

This Study Will Examine The Effects Of Exercise And Healthy Living Education On Brain Health, Cognition, And Physical Function In Older Adults With Cognitive Concerns.

Methylation Diet and Lifestyle Changes in Older Adult Men

Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.

This Study Will Evaluate A 9-week Diet And Lifestyle Intervention In Healthy Older Adult Men To Test whether Short-term Changes Can Affect DNA Methylation. Methylation Is an Epigenetic Change That Affects The Way Genes Function And Has Been Associated With Dementia And Other Conditions, Including Diabetes And Cancer. 

Physical Activity and Alzheimer's Disease (PAAD-2)

Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.

This Study Will Test A 1-year Exercise Program In Middle-aged Adults Who Have Normal Cognition And A Family History Of Alzheimer's Disease. Researchers Are Investigating How Exercise Effects Cognitive Performance And Whether Those Effects Are Influenced By APoE4, A Genetic Variant That Increases Risk For Alzheimer's Disease.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

This Research Will Examine The Effect On Cognition Of Increasing Physical Activity Using A Body-worn Sensor. Older Adults Will Be Asked To Increase Physical Activity For 12 Weeks While Wearing A Sensor Attached To A Belt That Will Monitor Activity.

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

This Study Will Examine How Different Types Of Training Activity Affect Older Adults' Cognitive Function, Brain Structure, Biomarkers Of Brain Health And Cognition, And Physical Function. In Addition, The Study Will Assess How An Individual's Cognitive And Physical Characteristics Influence Their Responsiveness To Each Type Of Training Activity.

Preventing Loss of Independence Through Exercise in Mild Cognitive Impairment (PLIE)

Purpose: To test an exercise program in older adults with mild cognitive impairment.

This Randomized, Controlled Trial Will Test The An Exercise Program In Older Adults With mild Cognitive Impairment (MCI) Who Live In The Community.

U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk (U.S. POINTER)

Purpose: To test the effects of lifestyle changes on memory loss and thinking in older Americans who are at risk for memory loss.

The Purpose Of This Study Is To See If Lifestyle Changes, Such As Exercise, Diet, And Cognitively Stimulating Activities, Can Protect Memory And Thinking In Older Adults Who Are At An Increased Risk Of Significant Memory Loss.

Water-based Activity to Enhance Recall in Veterans (WATER-VET)

Purpose: To evaluate the feasibility of a water-based exercise program with cognitive training to improve memory in veterans with mild cognitive impairment.

This Study Will Evaluate The Feasibility Of A Water-based Exercise Program, Along With A Cognitive Training Intervention, To Improve Memory In Veterans With Amnestic (memory-related) Mild Cognitive Impairment (aMCI).