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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 45

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

AGB101 for Preclinical Alzheimer's Disease

Purpose: To test whether the investigational drug AGB101 can reduce abnormal hyperfunctional activity in the hippocampus in healthy adults who are APOE 4 carriers.

AHEAD Study: BAN2401 for People With Increased Risk of Alzheimer's Disease

Purpose: To determine whether treatment with BAN2401 reduces brain amyloid accumulation in people with an increased risk for Alzheimer's disease.

AL001 for Frontotemporal Dementia

Purpose: To evaluate the safety and tolerability of AL001 in participants with frontotemporal dementia caused by a granulin mutation or C9orf72 mutation.

AVP-786 for the Treatment of Agitation in Alzheimer's

Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.

Azeliragon for Mild Alzheimer's and Diabetes (Elevage)

Purpose: To evaluate the efficacy and safety of the investigational drug azeliragon in adults with mild Alzheimer's disease and impaired glucose tolerance.

BAN2401 for People with Early Alzheimer's Disease (Clarity AD)

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease.

BPN14770 for Early Alzheimer's (PICASSO)

Purpose: To evaluate the effects of BPN14770 in older adults with early-stage Alzheimer's disease.

Biomarker Predictors of Memantine Sensitivity

Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

Brain Safe: Reducing Exposure to Drugs Linked to Alzheimer's

Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

Bryostatin for Moderate or Severe Alzheimer's Disease

Purpose: To test the safety, tolerability, and long-term effects of bryostatin for the treatment of moderately severe Alzheimer's disease.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)

Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.

Donanemab for Early-Stage Alzheimer's Disease

Purpose: To test the safety and effectiveness of donanemab to reduce cognitive decline and amyloid plaque in people with early-stage Alzheimers disease.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

Insulin Delivery for Memory Loss

Purpose: To test the effects of insulin delivered through the nose on memory in older adults.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

Lenalidomide for Amnestic Mild Cognitive Impairment

Purpose: To test whether lenalidomide reduces inflammation and improves cognition in people with amnestic mild cognitive impairment.

Leuprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA)

Purpose: To test leuprolide acetate (Eligard) in women with Alzheimer's disease taking a stable dose of donepezil (Aricept.)

Lithium to Prevent or Delay Dementia

Purpose: To test lithium as a treatment that may prevent or delay dementia in people with mild cognitive impairment.

Lu AF87908 for Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of Lu AF87908 in healthy participants and participants with Alzheimer's disease.

MW151 to Treat Cognitive Disorders

Purpose:: To test the safety and efficacy of MW151 to treat cognitive disorders.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin patch on memory performance in older adults with mild cognitive impairment (MCI).

Montelukast Therapy for Alzheimer's Disease

Purpose: To test montelukast as a treatment for people with mild cognitive impairment and early Alzheimer's dementia.

NNI-362 in Healthy Older Adults

Purpose: To examine the safety, tolerability, and pharmacokinetics of single and multiple doses of the investigational drug NNI-362 in healthy older adults.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

PTI-125 for Older Adults With Mild to Moderate Alzheimer's Disease

Purpose: To study the safety of PTI-125 medication and its effect on biomarkers, cognition, and neuropsychiatric symptoms in older adults with Alzheimer's disease.

Pimavanserin for Psychological Symptoms of Dementia

Purpose: To determine whether treatment with the drug pimavanserin decreases the psychological symptoms of dementia in older adults.

Posiphen for Early-Stage Alzheimer's and Parkinson's Diseases

Purpose: To determine the safety and tolerability of Posiphen in people with early Alzheimer's or early Parkinson's disease.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen® in older adults with early-stage Alzheimer’s disease.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

Safety and Tolerability of PNT001 in Healthy Adults

Purpose: To evaluate the safety and tolerability of PNT001 in healthy adults.

TRx0237 for Mild Alzheimer's

Purpose: To determine the safety and efficacy of the investigational treatment TRx0237 in older adults with early Alzheimer's disease.

Telmisartan to Prevent Alzheimer's in African Americans

Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.

Valacyclovir for Mild Alzheimer's Disease

Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.