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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 54

ACI-24 Vaccine in Adults with Down Syndrome

Purpose: To test the ACI-24 vaccine in adults with Down syndrome.

AD-35 for Mild to Moderate Alzheimer's

Purpose: To evaluate the safety, tolerability, efficacy, and behavior of AD-35 in older adults with mild to moderate Alzheimer's disease.

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

AL001 for Frontotemporal Dementia in Healthy Volunteers and People with FTD

Purpose: To assess the safety, tolerability, and behavior of the drug AL001 in healthy adult volunteers and people with frontotemporal dementia and the granulin mutation.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

AR1001 for Mild to Moderate Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of AR1001 in people with mild to moderate Alzheimer's disease.

AVP-786 for the Treatment of Agitation in Alzheimer's

Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.

AXS-05 for Agitation in Alzheimer's

Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.

Antidepressants to Prevent Mild Cognitive Impairment

Purpose: To test two antidepressants in people with subjective cognitive impairment.

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)

Purpose: To test methylphenidate (Ritalin®) as a treatment for clinically significant apathy in people with Alzheimer's disease.

Assessing J147 for Alzheimer's in Healthy Volunteers

Purpose: To assess the safety, tolerability, and pharmacokinetics of the investigational drug J147 in healthy young and older adults.

Azeliragon for Mild Alzheimer's and Diabetes (Elevage)

Purpose: To evaluate the efficacy and safety of the investigational drug azeliragon in adults with mild Alzheimer's disease and impaired glucose tolerance.

BAN2401 for People with Early Alzheimer's Disease

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease

BIIB092 in Primary Tauopathies

Purpose: To test the safety, tolerability, and effects of the investigational drug BIIB092 in people with one of four different tauopathy syndromes.

Biomarker Predictors of Memantine Sensitivity

Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

Brain Safe: Reducing Exposure to Drugs Linked to Alzheimer's

Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

CT1812 for Mild to Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of CT1812 in older adults with mild to moderate Alzheimer's disease.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)

Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

GAIN Trial: COR388 for Alzheimer's Disease

Purpose: To test the efficacy, safety, and tolerability of two doses of the investigational drug COR388 in older adults with mild to moderate Alzheimer's disease.

GRF6019 Infusions for Severe Alzheimer's Disease

Purpose: To evaluate the safety, tolerability, and potential cognitive benefit of the experimental treatment GRF6019 in older adults with severe Alzheimer's disease.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

LY3154207 for Parkinson's Disease Dementia (PRESENCE)

Purpose: To evaluate the safety and efficacy of the investigational drug LY3154207 in people with mild-to-moderate Parkinson's disease dementia.

Levetiracetam for Alzheimer's Disease-Associated Epileptiform Activity

Purpose: To test the use of levetiracetam, an anticonsulvant, to control seizures in people with Alzheimer's disease.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

NNI-362 in Healthy Older Adults

Purpose: To examine the safety, tolerability, and pharmacokinetics of single and multiple doses of the investigational drug NNI-362 in healthy older adults.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

ORY-2001 for Mild to Moderate Alzheimer's Disease (ETHERAL-US)

Purpose: To assess the safety, tolerability, and preliminary efficacy of the experimental drug ORY-2001 in adults with mild to moderate Alzheimer's disease.

PTI-125 for Mild-to-Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of multiple doses of the investigational drug PTI-125 in people with mild-to-moderate Alzheimer's disease.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen® in older adults with early-stage Alzheimer’s disease.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

RO7105705 for Moderate Alzheimer's Disease

Purpose: To evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of the investigational drug RO7105705 in older adults with moderate Alzheimer's disease.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

Safety and Efficacy of Gantenerumab for Early Alzheimer's

Purpose: To evaluate the safety and efficacy of the investigational drug gantenerumab in people with early Alzheimer's disease.

Salsalate for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and tolerability of twice daily salsalate in adults with mild to moderate Alzheimer's Disease.

Telmisartan to Prevent Alzheimer's in African Americans

Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.

Testing RO7126209 for Alzheimer's Disease in Healthy Volunteers

Purpose: To investigate the safety, tolerability, and pharmacokinetics of the investigational drug RO7126209 in healthy volunteers.

Treatment of Psychosis and Agitation in Alzheimer's Disease

Purpose: To test lithium as a treatment for psychosis and agitation in older adults with Alzheimer's disease.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.

Valacyclovir for Mild Alzheimer's Disease

Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.