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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 30

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

Rates of Change in Behavioral Variant Frontotemporal Dementia

Purpose: To study changes in cognitive function in adults with early-stage behavioral variant frontotemporal dementia.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

Tau PET Imaging Using 18F-AV-1451

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Cognitive Detection of Preclinical Alzheimer's: Validation Using Biomarkers

Purpose: To validate several novel cognitive tasks and correlate them with Alzheimer's disease biomarkers in people who are cogntitively normal or have mild cognitive impairment.

Tau PET Imaging in the Dominantly Inherited Alzheimer Network

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans to identify tau tangles.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

Purpose: To evaluate the effects of surgical anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

Biomarkers in Lewy Body Dementia

Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

Tau Screening in Early Alzheimer's Disease

Purpose: To prescreen older adults with early Alzheimer’s disease who may be eligible for therapeutic trials requiring tau imaging.