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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 31

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

The Goal Of This Observational Study Is To Identify Reliable Methods For Tracking The Progression Of Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), And Oligosymptomatic/variant Progressive Supranuclear Palsy (o/vPSP) Over Time.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

This Study Aims To Better Understand The Relationship Between Variations Of The APOE Gene And Metabolism By Testing Metabolic Rate At Rest And During A Cognitive Challenge In Healthy Adults. Results May Help Investigators Identify New Targets For The Prevention And Treatment Of Cognitive Decline And Dementia.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

The Purpose Of This Observational Study Is To Determine The Relationships Among Clinical, Cognitive, Imaging, Genetic, And Biomarker Characteristics Of The Entire Spectrum Of Alzheimer's Disease As It Progresses From A Preclinical Stage To Very Mild Symptoms To Mild Cognitive Impairment (MCI) To Dementia. Participants Sought Include Those With Normal Cognition, MCI, Or Mild Alzheimer's Dementia (currently Recruiting Non-Caucasian Participants Only For The Normal Cognition Group).

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Traumatic Brain Injury (TBI) And Post Traumatic Stress Disorder (PTSD) Are Common Combat-related Problems And May Be Associated With A Greater Risk Of Alzheimer's Disease. This Study Will Examine The Possible Connections Between TBI And PTSD, And The Signs And Symptoms Of Alzheimer's In Vietnam War Veterans As They Age.

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

This Phase I/II Study Will Test The Effects Of The Investigational Drug CT1812 On Brain Synaptic Density In Adults With Mild To Moderate Alzheimer's Disease.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

This Clinical Trial Will Use Positron Emission Tomography (PET) Scanning To Measure The Clearance Of Waste From The Brain Via Cerebrospinal Fluid. The Objective Is To Determine The Role Of Impaired Clearance In The Buildup Of The Amyloid Protein In The Aging Brain And Risk For Alzheimer's Disease. A Harmful Form Of Amyloid Is Seen In The Brains Of People With Alzheimer's.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

This Study Examines The Impact On Older Adults Of Learning The Results Of Amyloid Brain Imaging, Which Can Indicate Risk For Alzheimer's Disease. 

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

This Study Will examine The Feasibility Of Biochemical Assays, Genetic Testing, And Cognitive And Lifestyle Assessments In The Diagnosis Of Alzheimer's Disease, Mild Cognitive Impairment, And Other Neurodegenerative Diseases. The Study Also Aims To Assess Changes In Biological, Lifestyle, And Cognitive Assessments Collected From Individuals Over Time.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

This Study Will Examine The Effect Of Different Types Of Meals On Cognitive Function And Alzheimer's Biomarkers In Healthy Older Adults With And Without The APOE E4 Genotype. 

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

This Study Will Use A Variety Of Assessments And Clinical And Biological Measures To Characterize Adults With Three Different Disorders: Alzheimer's Disease, Lewy Body Dementia, And Parkinson's Disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

The Purpose Of This Study Is To Identify Potential Biomarkers That May Predict The Development Of Alzheimer's Disease In People Who Carry An Alzheimer's Mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

This Study Will Determine If The Alzheimer's Disease Drug Memantine Hydrochloride Can Improve Learning And Memory In Adolescents And Young Adults With Down Syndrome.

Early-Onset Alzheimer's Disease Genomic Study

Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.

This Study Will Collect Samples From People With Early-onset Alzheimer's Disease And Their Immediate Family Members to Better Understand How Changes In The Body Are Related To Development Of The Disease.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

This Study Will Test The Hypothesis That The Presence Of Beta-amyloid Plaques In The Braina Hallmark Of Alzheimer's Diseasein Non-demented Older Patients Increases The Likelihood Of cognitive Decline After scheduled Hip Or Knee Replacement Surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

This Study Will Examine The Sensitivity Of Functional Magnetic Resonance Imaging (fMRI) To Detect Brain Changes In Healthy Older Adults At Genetic Risk For Alzheimer's Disease Who Take The Drug Donepezil (Aricept). Participants With A Family History Of Alzheimer's Are Eligible For This Study. Participants Without A Family History Of Alzheimer's Can Be enrolled To Serve As A Control Group.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

The EASES Study Is A 2-year Observational Study Designed To Measure Brain Function During The Onset And Progression Of Mild Cognitive Impairment (MCI) In Older Adults using Quantitative Electroencephalography (qEEG).

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

This Study Will Test The Ability Of The Radioactive Tracer 11C-ER176 To Stick To Parts Of The Brain Where There Is Inflammation. Past Studies Have Shown That Inflammation Is Present In The Brains Of People With Alzheimer's Disease.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

This Observational Study Will Track Cognitive And Neural Biomarkers In People Younger Than 50 Who Are Overweight Or Obese And Have Metabolic Risk Factors Associated With Cognitive Decline Later In Life.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Is A 2-year Observational Study Designed To Look At Disease Progression In Adults With Early-onset Alzheimer's Disease. Researchers Are Also Recruiting Cognitively Normal Volunteers For A 1-year Comparison.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

The Purpose Of This Study Is To Learn About Thinking And Behavior In Families In Which One Or More Relatives Has A Genetic Mutation Associated With Frontotemporal Dementia.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

This Observational Study Will Examine Changes In brain-region Size, Shape, And Activity That Occur In Women With Breast Cancer And How Those Changes Relate To The Development Of Mild Cognitive Impairment. Three Groups Will Be Compared: Women With Breast Cancer Who Will Undergo Hormonal Therapy With Or Without Chemotherapy, Women With Breast Cancer Who Will Undergo No Therapy Or Radiation Therapy, And Healthy Female Volunteers.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

In This Observational Study, Researchers Will Document The Clinical Features And Biological Markers Of People With Synucleinopathies (Parkinson's Disease, Dementia With Lewy Bodies, Or Multiple System Atrophy) And Those In A Pre-dementia Stage To Better Understand How These Disorders Evolve Over Time.

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

This study Will Investigate Pupillary Light Response As A Potential Detection Method For progressive Supranuclear Palsy (PSP) In Adults With PSP Or Other Neurodegenerative Diseases.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Researchers Will Use Magnetic Resonance Imaging (MRI) To Investigate Brain Function And Connections In Healthy Adults. This Might Help People With Brain Diseases In The Future.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Riluzole, A Drug Used To Slow Down The Progress Of Amyotrophic Lateral Sclerosis (ALS), Will Be tested In People With Mild Alzheimer's Disease. Cognitive Functional Changes And Specific Imaging Biomarkers Will Be Evaluated.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

This Study Plans To Establish A Large Bank Of Blood, Cerebrospinal Fluid, Imaging, And Clinical Data To Be Used In Alzheimer's Disease Research.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

This Study Of Aging And The Brain Is Looking For Healthy Older Adults To Participate In Brain Imaging, Genetic Testing, Memory Testing, And Analysis Of Proteins In The Blood And Spinal Fluid. The Goal Is To Develop Biological Markers To Aid In Better Understanding, Early Detection, And Treatment Of Alzheimer’s Disease.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

This Study Will Use The New Radioactive Tracer 18F-MK-6240 In Positron Emission Tomography (PET) Scanning To Detect Tau Pathology In Older Adults Who Are Cognitively Healthy And Mildly Cognitively Impaired.

Tau PET Imaging Using 18F-AV-1451

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.

This Study Will Evaluate A New Radioactive Compound, 18F-AV-1451, In Identifying Tau Tangles In Positron Emission Tomography (PET) Scans. Tau Is A Protein That Accumulates Abnormally In The Brains Of People With Alzheimer's Disease And Other Neurodegenerative Disorders.

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

This Study Will Explore The Use Of Transcranial Magnetic Stimulation (TMS) Integrated With Functional Magnetic Resonance Imaging (fMRI) For Diagnosing Preclinical Dementia. This Research Will Support Development Of A More Sensitive Diagnostic Tool For Dementia.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

This Observational Study Aims To Identify And Distinguish Two Different Types Of Progressive Apraxia Of Speech (PAOS), A Disorder Associated With Neurodegenerative Disease And Dementia, Through Clinical Imaging And Testing Of Adults With PAOS.