Find Alzheimer’s Disease and Related Clinical Trials
Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.
Results found: 44
Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.
Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.
Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.
Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.
Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.
Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.
Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.
Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).
Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.
Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.
Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.
Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.
Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.
Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.
Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.
Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.
Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).
Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.
Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.
Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.
Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.
Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.
Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.
Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.
Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).
Purpose: To examine the relationship between brain energetics and risk for Alzheimer's disease.
Purpose: To enroll adults with idiopathic rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.
Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.
Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.
Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).
Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.
Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.
Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.
Purpose: To study memory and aging in healthy older adults.
Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.
Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.
Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.
Purpose: To evaluate a new radioactive compound used in positron emission tomography scans to identify tau tangles.
Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.
Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.
Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.
Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.