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Find Alzheimer’s Disease and Related Clinical Trials

Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.

Clinical Trials Search Results

Results found: 169

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

ABBV-8E12 for Early Alzheimer's Disease

Purpose: To evaluate ABBV-8E12 in older adults with early Alzheimer's disease.

ABBV-8E12 for Progressive Supranuclear Palsy

Purpose: To assess the safety, dosing, and action of ABBV-8E12, an anti-tau antibody, in people with progressive supranuclear palsy.

ACI-24 Vaccine in Adults with Down Syndrome

Purpose: To test the ACI-24 vaccine in adults with Down syndrome.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

Alzheimer's Disease, Caregiving, and Social Networks

Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.

Alzheimer's Disease Genetics Study

Purpose: To identify the genes that cause late-onset Alzheimer's disease.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

Alzheimer's Prevention Through Exercise

Purpose: To learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

ALZT-OP1 for Early-Stage Alzheimer's Disease

Purpose: To test ALZT-OP1 as a treatment for cognitive and functional decline in people with early-stage Alzheimer's disease.

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)

Purpose: To test methylphenidate (Ritalin®) as a treatment for clinically significant apathy in people with Alzheimer's disease.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

AstroStem to Treat Alzheimer's Disease

Purpose: To test the safety and efficacy of an investigational stem cell drug, AstroStem, for treating the symptoms of Alzheimer's disease in older adults.

Auditory Stimulation of Slow-Wave Sleep and Memory in Older Adults

Purpose: To evaluate the ability of sounds played during slow-wave sleep to enhance sleep and memory in older adults.

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

AVP-786 for Agitation in Dementia of the Alzheimer's Type

Purpose: To test the experimental drug AVP-786 as a treatment for agitation in people with Alzheimer's dementia.

AXS-05 for Agitation in Alzheimer's

Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

Behavioral Interventions for Mild Cognitive Impairment

Purpose: To compare the impact of a walking program, computer-based cognitive training program, and both programs in adults with mild cognitive impairment.

Benfotiamine in Alzheimer's Disease

Purpose: To determine whether treatment with benfotiamine, a dietary supplement, minimizes cognitive decline in older adults with amnestic mild cognitive impairment or mild Alzheimer's disease.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

BIIB092 for Progressive Supranuclear Palsy (Passport)

Purpose: To evaluate the safety and efficacy of BIIB092 compared to placebo in treating progressive supranuclear palsy.

Biomarkers in Lewy Body Dementia

Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.

Bisnorcymserine in Healthy Adult Volunteers

Purpose: To test the safety and action of the drug bisnorcymserine in healthy older volunteers.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti®) in older adults with agitation associated with Alzheimer's disease.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

CADASIL Disease Discovery

Purpose: To learn more about cerebral autosomal dominant arteriopathy with subcortical infarct (CADASIL).

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

Care Partners Program for Alzheimer's Disease

Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.

Cathodal Transcranial Direct Current Stimulation in MCI

Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.

Cholinesterase Inhibitor Discontinuation

Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.

Citicoline for Age-Associated Memory Impairment

Purpose: To determine the effects of citicoline on cognitive performance in healthy adults with age-associated memory impairment.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

Cognitive and Aerobic Resilience for the Brain (CARB)

Purpose: To test the impact of cognitive and/or exercise training on cognition in older adults with mild cognitive impairment.

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Detection of Preclinical Alzheimer's: Validation Using Biomarkers

Purpose: To validate several novel cognitive tasks and correlate them with Alzheimer's disease biomarkers in people who are cogntitively normal or have mild cognitive impairment.

Cognitive Function in Adults With and Without HIV

Purpose: To better understand how the HIV virus affects the brain and cognitive aging.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

Cognitive Training and Practice Effects in MCI

Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.

Cognitive Training and Transcranial Direct Current Stimulation for HIV-Related Cognitive Dysfunction

Purpose: To test the effects of cognitive training and transcranial direct current stimulation on cognitive function in older adults with HIV-related cognitive dysfunction.

Cognitive Training and Vortioxetine for Age-Related Cognitive Decline

Purpose: To examine the potential benefits of a combination of at-home cognitive training and Trintellix® on cognition in older adults with age-related cognitive decline.

Cognitive Training for Fall Prevention

Purpose: To test whether cognitive training can help decrease falls in older adults who are at risk for falls.

Cognitive Training to Improve Brain Function

Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

COR388 in Healthy Volunteers and People with Alzheimer's

Purpose: To assess the safety and tolerability of the investigational drug COR388 in healthy older adults and those with Alzheimer's disease.

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

Crenezumab for Early Alzheimer's Disease (CREAD 2)

Purpose: To evaluate the efficacy and safety of crenezumab in adults with prodromal to mild Alzheimer's disease.

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

Cycling Exercise for Treating Alzheimer's Disease

Purpose: To investigate the effects of a cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease.

Dietary Flavanols and Dentate Gyrus Function

Purpose: To assess the effect of a cocoa-derived dietary supplement on cognitive function related to the dentate gyrus.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

Dietary Treatments for Cognitive Impairment

Purpose: To study the effect on cognition of a modified Atkins diet in older adults with mild cognitive impairment or early Alzheimer's disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

E2027 in Healthy Subjects

Purpose: To evaluate the safety, tolerability, and pharmacodynamics of E2027 in healthy participants.

E2609 for MCI and Early Alzheimer's (Mission AD1)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

E2609 for MCI and Early Alzheimer's (Mission AD2)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

Purpose: To evaluate the effects of surgical anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

EMERGE: Aducanumab (BIIB037) for Early Alzheimer's Disease

Purpose: To evaluate treatment of early Alzheimer's disease with the experimental drug aducanumab (BIIB037).

ENGAGE: Aducanumab (BIIB037) for Early Alzheimer's Disease

Purpose: To evaluate treatment of early Alzheimer's disease with the experimental drug aducanumab (BIIB037).

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Family Telemental Health Intervention for Veterans with Dementia

Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.

GeneMatch

Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

Grape Seed Extract for Alzheimer's Disease

Purpose: To establish the safety and pharmacokinetics of grape seed extract and to test its cognitive effects in people with Alzheimer's disease.

Healthy Volunteers for Donepezil Skin Patch for Alzheimer's

Purpose: To evaluate the safety and pharmacokinetics of a transdermal donepezil patch applied to different body locations on healthy volunteers.

Home Visits for Progressive Supranuclear Palsy and Related Disorders (CarePSP)

Purpose: To test a home visit program designed to assess the needs of people with progressive supranuclear palsy (PSP) or related disorders and to connect them with services.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

Insulin Aspart to Fight Forgetfulness

Purpose: To test the effects of fast-acting intranasal insulin on cognition and daily function in people with Alzheimer's disease or mild cognitive impairment.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

Intermittent Calorie Restriction, Insulin Resistance, and Brain Function

Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.

Intranasal Glulisine for Amnestic MCI or Mild Alzheimer's Disease

Purpose: To evaluate the use of intranasal glulisine in people with amnestic mild cognitive impairment or mild Alzheimer's disease.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

ITI-007 for Agitation in Dementia

Purpose: To study the use of ITI-007 to treat agitation in people with dementia, including Alzheimer's disease.

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

LY3002813 and LY3202626 for Early Alzheimer's Disease (TRAILBLAZER-ALZ)

Purpose: To evaluate the safety, tolerability, and efficacy of the investigational drugs LY3002813 and LY3202626 in older adults with early symptomatic Alzheimer's disease.

LY3002813 for Mild Cognitive Impairment or Alzheimer's Disease

Purpose: To evaluate the effect of LY3002813 in people with mild cognitive impairment or Alzheimer's disease.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

Methylation Diet and Lifestyle Changes in Older Adult Men

Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Mindfulness-Based Stress Reduction, Health Education, and Exercise

Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.

Movement and Music for Older Adults with Dementia

Purpose: To learn about the possible benefits of movement and music in older adults with dementia.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

Natural History of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To characterize the natural history of disease in people who carry a repeat expansion in the C9ORF72 gene, which causes amyotrophic lateral sclerosis and frontotemporal dementia.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

Neflamapimod for MCI or Mild Alzheimer's Disease

Purpose: To test the effects of the investigational drug neflamapimod on memory and cognitive function in older adults with mild cognitive impairment or mild Alzheimer's disease.

Neural Basis of Frontotemporal Degeneration and Related Disorders

Purpose: To study adults with frontotemporal degeneration, multiple systems atrophy, and progressive supranuclear palsy to better understand the causes of these disorders.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant®, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nilotinib for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and efficacy of the drug nilotinib in people with mild to moderate Alzheimer's disease.

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Optimizing Dementia Care for Veterans and Their Caregivers

Purpose: To examine the effectiveness of an established counseling approach and a variation of it for veterans with dementia and their family caregivers who have high levels of stress. 

Optimizing Postoperative Cognition in the Elderly

Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.

Palliative Care for Parkinson's and Related Disorders

Purpose: To compare usual care to palliative care for adults with Parkinson's disease and related disorders.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

Pimavanserin for Relapse of Dementia-Related Psychosis

Purpose: To evaluate the efficacy of the drug pimavanserin (Nuplazid®) in preventing a relapse of psychotic symptoms in adults with who were previously stabilized after 12 weeks of treatment.

Piromelatine for Mild Alzheimer's Disease (ReCOGNITION)

Purpose: To test the safety and efficacy of the experimental drug piromelatine in people with mild Alzheimer's dementia.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen® in older adults with early-stage Alzheimer’s disease.

Pragmatic Trial of Video Education in Nursing Homes (PROVEN)

Purpose: To test the use of a video about advance care planning for nursing home residents.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

Program for African American Cognition and Exercise (PAACE)

Purpose: To develop and evaluate a program to increase physical activity and improve cognitive function in African-American older adults who are sedentary.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

Rates of Change in Behavioral Variant Frontotemporal Dementia

Purpose: To study changes in cognitive function in adults with early-stage behavioral variant frontotemporal dementia.

Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia

Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Repetitive Transcranial Magnetic Stimulation for Dementia

Purpose: To determine if repetitive transcranial magnetic stimulation improves cognitive function in people with mild to moderate cognitive impairment or dementia.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

RO7105705 for Prodromal to Mild Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the experimental drug RO7105705 in people with prodromal to mild Alzheimer's disease.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

Salsalate for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and tolerability of twice daily salsalate in adults with mild to moderate Alzheimer's Disease.

Self-Management of Chronic Pain and Negative Emotions

Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

SPIRIT for End-of-Life Decision Making in Mild Alzheimer's

Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild Alzheimer's disease and their surrogates to promote end-of-life care discussions.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

SUVN-502 with Donepezil and Memantine for Moderate Alzheimer's Disease

Purpose: To test the experimental drug SUVN-502 as a treatment for moderate Alzheimer's disease in people taking donepezil and memantine.

Tau Imaging for Alzheimer's Trial Participation

Purpose: To prescreen older adults who have cognitive impairment or early Alzheimer's disease and may be eligible for therapeutic trials that require tau imaging.

Tau PET Imaging in the Dominantly Inherited Alzheimer Network

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans to identify tau tangles.

Tau PET Imaging Using 18F-AV-1451

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.

Tau Screening in Early Alzheimer's Disease

Purpose: To prescreen older adults with early Alzheimer’s disease who may be eligible for therapeutic trials requiring tau imaging.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

Telmisartan to Prevent Alzheimer's in African Americans

Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

Transcranial Direct Current Stimulation for Mild Cognitive Impairment

Purpose: To explore transcranial direct current stimulation as a way to improve word finding and memory retrieval in adults with mild cognitive impairment.

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.

Transcutaneous Vagal Nerve Stimulation for MCI

Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.

Treatment of Psychosis and Agitation in Alzheimer's Disease

Purpose: To test lithium as a treatment for psychosis and agitation in older adults with Alzheimer's disease.

Trial of Oxaloacetate in Alzheimer's Disease (TOAD)

Purpose: To determine if oxaloacetate is safe and tolerable in people with Alzheimer's disease.

TRx0237 for Mild Alzheimer's

Purpose: To determine the safety and efficacy of the investigational treatment TRx0237 in older adults with mild Alzheimer's disease.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

Valacyclovir for Mild Alzheimer's Disease

Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.

Vision-based Speed of Processing Training for Mild Cognitive Impairment

Purpose: To identify brain changes in adults with mild cognitive impairment who engage in vision-based speed of processing cognitive training.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.

Water-based Activity to Enhance Recall in Veterans (WATER-VET)

Purpose: To evaluate the feasibility of a water-based exercise program with cognitive training to improve memory in veterans with mild cognitive impairment.

Xanamem for Mild Alzheimer's Disease

Purpose: To assess the experimental drug Xanamem® in older adults with mild Alzheimer's disease.

Yoga and Meditation for Reducing Alzheimer's Risk in Women with MCI

Purpose: To test the effects of kundalini yoga and kirtan kriya yogic meditation, in comparison to memory training, in improving cognitive function, health, and mood in older adult women with mild cognitive impairment.