Find Alzheimer’s Disease and Related Clinical Trials

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

The Goal Of This Observational Study Is To Identify Reliable Methods For Tracking The Progression Of Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), And Oligosymptomatic/variant Progressive Supranuclear Palsy (o/vPSP) Over Time.

ABBV-8E12 for Early Alzheimer's Disease

Purpose: To evaluate ABBV-8E12 in older adults with early Alzheimer's disease.

This Study Will Evaluate The Efficacy And Safety Of ABBV-8E12, An Anti-tau Antibody, In Older Adults With Early Alzheimer's Disease.

ACI-24 Vaccine in Adults with Down Syndrome

Purpose: To test the ACI-24 vaccine in adults with Down syndrome.

This Phase I Study Will Test The ACI-24 Vaccine In Adults With Down Syndrome To Assess Whether The Vaccine Is Safe, Tolerable, And Able To Stimulate An Immune Response.

AD-35 for Mild to Moderate Alzheimer's

Purpose: To evaluate the safety, tolerability, efficacy, and behavior of AD-35 in older adults with mild to moderate Alzheimer's disease.

This Phase II Trial Will Test The Safety, Tolerability, And Effects Of AD-35 On Cognitive Function In Older Adults With Mild To Moderate Alzheimer's Disease.

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

This Phase III Clinical Trial Will Evaluate Whether AGB101 Slows Cognitive And Functional Impairment In People With Prodromal Alzheimer's Disease (mild Cognitive Impairment Due To Alzheimer's)

ALZT-OP1 for Early-Stage Alzheimer's Disease

Purpose: To test ALZT-OP1 as a treatment for cognitive and functional decline in people with early-stage Alzheimer's disease.

This Phase III Clinical Trial Will Test The Experimental Drug ALZT-OP1 As A Treatment For People With Early-stage Alzheimer's Disease. Researchers Will Evaluate The Drug's Safety And Tolerability And Determine If It Can Slow Down, Stop, Or Reverse Cognitive And Functional Decline.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

This Phase II Study Will Assess The Safety, Tolerability, And Effects Of The Investigational Drug AMX0035 For People With Late Mild Cognitive Impairment Or Early Dementia Due To Alzheimer's Disease.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

This Study Aims To Better Understand The Relationship Between Variations Of The APOE Gene And Metabolism By Testing Metabolic Rate At Rest And During A Cognitive Challenge In Healthy Adults. Results May Help Investigators Identify New Targets For The Prevention And Treatment Of Cognitive Decline And Dementia.

AXS-05 for Agitation in Alzheimer's

Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.

This Phase II/III Randomized Trial Will Assess The Efficacy And Safety Of AXS-05, An Investigational Drug Combining FDA-approved Bupropion And Dextromethorphan, To Treat agitation In Older Adults With Alzheimer's Disease.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

The Goal Of This Study Is To Build A Clinical Research Consortium To Test New Treatments For People With Frontotemporal Lobar Degeneration (FTLD), Including Frontotemporal Dementia (FTD), Primary Progressive Aphasia (PPA), Corticobasal Degeneration (CBS), And Progressive Supranuclear Palsy (PSP).

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Combining Aerobic Exercise And Cognitive Training, This Study Will Compare The Effects Of Cycling And Cognitive Training Alone And Together in Older Adults With Mild Cognitive Impairment (MCI).

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

This Study Will Examine The Impact Of Cognitive Training And Aerobic Exercise In Sedentary Older Adults, Specifically Older Adults At Risk For Mobility Disability. Participants Will Be Randomly Assigned To Either A Group That Does Cognitive Training Alone Or A Group That Does Combined Cognitive Training And Aerobic Exercise.

Alzheimer Prevention Trials (APT) Webstudy

Purpose:To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

The Alzheimer Prevention Trials (APT) Webstudy Is An Online Registry Designed To Accelerate Enrollment For Alzheimer's Disease Clinical Trials By Identifying And Tracking Individuals Who May Be At Higher Risk For Developing Alzheimer's dementia.

Alzheimer's, Autism, and Cognitive Impairment Stem Cell Treatment Study (ACIST)

Purpose: To evaluate the effects of stem cell therapy and infrared light treatment on cognitive function in Alzheimer's disease and related dementias and on behavior in adult autism spectrum disorder.

This study Will Evaluate The Use Of Autologous Bone Marrow-derived Stem Cells And Near Infrared Light To Improve Cognitive Impairment In Alzheimer's And Related Dementias And To Improve Behavior And Socialization Issues In Adult Autism Spectrum Disorder.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

This Study Will Compare Two Intervention Strategies For Reducing Emotional And Cardiovascular Disease Risk In Alzheimer's Caregivers: Behavioral Activation Therapy And Support And Information.

Alzheimer's Disease, Caregiving, and Social Networks

Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.

Most Studies On Alzheimer's Disease (AD) Caregiving Focus On The Primary Caregiver. More Research Is Needed On How The Disease Affects The Broader Family Network. In This Study, Researchers Will Examine Caregiving In A Family Social Network To consider How All Family Caregivers Adapt To Their Roles. At Least One Caregiver And One Family Member Who Provides Care Indirectly (e.g., Supports The Caregiver) Will Be Surveyed. Researchers Will Also Compare levels Of Perceived Family Health History Risk.

Alzheimer's Disease Genetics Study

Purpose: To identify the genes that cause late-onset Alzheimer's disease.

The Purpose Of The Alzheimer's Disease Genetics Study Is To Identify And Analyze The Genes That Cause Late-onset Alzheimer's Disease. Researchers Are Collecting Genetic Material From Families In The United States In Which Two Or More Members Have Late-onset Alzheimer's.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

The Purpose Of This Observational Study Is To Determine The Relationships Among Clinical, Cognitive, Imaging, Genetic, And Biomarker Characteristics Of The Entire Spectrum Of Alzheimer's Disease As It Progresses From A Preclinical Stage To Very Mild Symptoms To Mild Cognitive Impairment (MCI) To Dementia. Participants Sought Include Those With Normal Cognition, MCI, Or Mild Alzheimer's Dementia (currently Recruiting Non-Caucasian Participants Only For The Normal Cognition Group).

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

The Alzheimer's Prevention Registry Is A National Registry Of Individuals Age 18 And Older Who Are Interested In Learning About And Possibly Participating In Alzheimer's Prevention Clinical Studies And Trials. The Registry Will Collect Contact And Demographic Information, Provide Information About The Latest News And Advances In Alzheimer's Prevention Research, And Inform Enrollees About Research Studies In Their Community.

Antidepressants to Prevent Mild Cognitive Impairment

Purpose: To test two antidepressants in people with subjective cognitive impairment.

This Study Will Test Two Antidepressants, Escitalopram (Lexapro) And Venlafaxine (Effexor XR), To Assess Their Effects On Memory And Cognition In People With Subjective Cognitive Impairment. Participants Are Cognitively Normal But Are Concerned About Their memory.

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)

Purpose: To test methylphenidate (Ritalin^®) as a treatment for clinically significant apathy in people with Alzheimer's disease.

ADMET 2 Will Test Methylphenidate (Ritalin^®), A Drug Approved To Treat Symptoms Of Attention Deficit Hyperactivity Disorder And Narcolepsy, As Treatment For Clinically Significant Apathy In People With Alzheimer's Disease.

AstroStem to Treat Alzheimer's Disease

Purpose: To test the safety and efficacy of an investigational stem cell drug, AstroStem, for treating the symptoms of Alzheimer's disease in older adults.

This Phase I/II Study Will Test The Safety And Efficacy Of An Investigational Stem Cell Drug, AstroStem, For Treating The Symptoms Of Alzheimer's Disease.

Auditory Stimulation of Slow-Wave Sleep and Memory in Older Adults

Purpose: To evaluate the ability of sounds played during slow-wave sleep to enhance sleep and memory in older adults.

This Study Will Evaluate The Ability Of Sounds Played During Slow-wave Sleep To Enhance Sleep And Memory In Cognitively Healthy Older Adults And In Those With Amnestic Mild Cognitive Impairment (aMCI).

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

This Study Will Test The Effects Of Different Kinds Of Auditory Training On Hearing Function In Healthy Adults. Hearing Loss Has Been Associated With Cognitive Decline And Decreased Quality Of Life, And Researchers Are Exploring Whether Such Auditory Training Could Compensate For And/or Reverse Hearing Deficits In Older Adults.

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

People With Mild Cognitive Impairment (MCI) Are At Risk Of Developing Dementia. Those With Deficits In Short-term Recall (amnestic MCI) Are At Significant Risk Of Developing Alzheimer's Disease. In This Study, People With MCI And Prediabetes Will Consume A Nutraceutical Drink, Called A Bioactive Dietary Polyphenol Preparation (BDPP), To See If It Can Improve Cognition And Delay Or Prevent Dementia.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

The Purpose Of This Study Is To Evaluate A Brain Fitness Intervention For improving Cognitive Health In Middle-aged And Older Adults.

BHV-4157 for Alzheimer's Disease (T2 Protect AD)

Purpose: To test the investigational drug BHV-4157 as a possible treatment and prevention for the symptoms of Alzheimer's disease.

BHV-4157, Also Known As Troriluzole, Is An Investigational Drug That Researchers Are Testing To Determine If It Can Protect Against, Slow Down, And Potentially Improve Memory And Thinking Problems In Adults With Mild To Moderate Alzheimer's Disease.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

This Study Will Evaluate The Safety And Tolerability Of BIIB076 In Cognitively Normal Older Adults And Older Adults With Alzheimer's Disease.

BIIB092 for Early Alzheimer's Disease (TANGO)

Purpose:: To evaluate BIIB092 in people with mild cognitive impairment due to Alzheimer's disease or mild Alzheimer's disease.

The Study Will Evaluate BIIB092, A Monoclonal Antibody, In People With Mild Cognitive Impairment (MCI) Due To Alzheimer's Disease Or Mild Alzheimer's Disease.

BIIB092 in Primary Tauopathies

Purpose: To test the safety, tolerability, and effects of the investigational drug BIIB092 in people with one of four different tauopathy syndromes.

This Phase 1b Randomized Clinical Trial Will Test The Safety, Tolerability, And Effects Of The Investigational Drug BIIB092, A Monoclonal Antibody, When It Is Intravenously Infused In People That Have One Of Four Different Tauopathy Syndromes.

Behavioral and Environmental Sensing and Intervention (BESI)

Purpose: To develop and assess a tool enabling caregivers to recognize dementia-related agitation and intervene before it escalates.

The Goal Of This Study Is To Develop and Evaluate A Tool To Help Caregivers Recognize Dementia-related Agitation And Intervene Before The Distress Escalates. The Tool Is Designed To Help Reduce Caregiver Burden And Extend Aging-in-place For People With Dementia.

Benfotiamine in Alzheimer's Disease

Purpose: To determine whether treatment with benfotiamine, a dietary supplement, minimizes cognitive decline in older adults with amnestic mild cognitive impairment or mild Alzheimer's disease.

This Clinical Trial Will Determine If Benfotiamine, A Dietary Supplement, Can Minimize Cognitive Decline In Older Adults With Amnestic Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

This Phase II Study Will Test Whether Lowering Blood Pressure Using Antihypertensive Drugs Alters Brain Pulsatility, A Measure Of Blood Flow, And Reduces Amyloid-beta Accumulation In The Brains Of Older Adults.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Traumatic Brain Injury (TBI) And Post Traumatic Stress Disorder (PTSD) Are Common Combat-related Problems And May Be Associated With A Greater Risk Of Alzheimer's Disease. This Study Will Examine The Possible Connections Between TBI And PTSD, And The Signs And Symptoms Of Alzheimer's In Vietnam War Veterans As They Age.

Brain Care for Veterans with Alzheimer's or Traumatic Brain Injury (ABC ANSWERS)

Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.

Most people With Alzheimer's Disease Or Traumatic Brain Injury receive Significant Amounts Of Care From family Members Or Friends. This Study Will Test An Intervention That Is Designed To Improve The Informal Care Of Veterans With Alzheimer's Disease Or Traumatic Brain Injury And To Reduce The Burden On Their caregivers.

Brain Connections, Self-Care, and Blood Pressure in African Americans with Memory Problems

Purpose:To evaluate a dietary and mindfulness intervention to decrease blood pressure and improve brain function in black and African-American older adults with high blood pressure and early Alzheimer's disease or a related dementia.

This Study Is Designed To Help Adapt A Previously Tested Intervention Involving The DASH (Dietary Approaches To Stop Hypertension) Diet And Mindfulness Techniques For Black And African American Older Adults With High Blood Pressure And Early Alzheimer's Disease Or A Related Dementia.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

The Purpose Of The Online Brain Health Registry Is To Recruit And Observe People Who Are Interested In Promoting Healthy Brain Function Through The Prevention Of Brain Diseases, Disorders, And Injuries In Adults. Participation Involves Answering Questions About Your Health, Lifestyle, And Medical History And Taking Online Brain Tests. Researchers Hope To Build A Large Pool Of Potential Participants For Clinical Trials, Reducing The Time And Cost Of Research.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

This Phase III Study Compares The Efficacy Of Two Different Doses Of Brexpiprazole (Rexulti) With Placebo In Older Adults Who Are Experiencing Agitation Associated With Alzheimer's Disease.

Bryostatin for Moderate to Severe Alzheimer's Disease

Purpose: To test bryostatin as a treatment for moderate to severe Alzheimer's disease in older adults not receiving memantine (Namenda or Namzaric).

This Phase II Study Will Test The Investigational Drug Bryostatin As A Treatment For Moderate To Severe Alzheimer's Disease In Older Adults Not Receiving Memantine (Namenda Or Namzaric).

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

This Clinical Trial Will Test Whether Two Investigational Drugs, CAD106 And CNP520, Administered Separately, Can Prevent Or Delay Alzheimer's Disease Symptoms In People At High Risk Of Developing Dementia Based On Their Age And Genetic Status.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

The Generation 2 Study Will Test The Safety And Effects Of The Investigational Drug CNP520 in Cognitively Normal Older Adults Who Are At risk Of Developing Dementia Based On Their Age, Genetic Status, And Brain Amyloid Levels.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

The Purpose Of This 1-year Study Is To Determine Whether Treatment Of Obstructive Sleep Apnea With A Continuous Positive Airway Pressure (CPAP) Machine Can Delay The Progression Of Cognitive Impairment In Older Adults With Mild Cognitive Impairment (MCI).

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

This Phase I/II Study Will Test The Effects Of The Investigational Drug CT1812 On Brain Synaptic Density In Adults With Mild To Moderate Alzheimer's Disease.

CT1812 for Mild to Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of CT1812 in older adults with mild to moderate Alzheimer's disease.

This Phase II Trial Will Study The Safety And Efficacy Of Two Different Doses Of The Investigational Drug CT1812 In Adults With Mild To Moderate Alzheimer's Disease.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

This Phase II Study Will Investigate The Effect Of Candesartan, A Medication Used To Treat High Blood Pressure, On Cognitive Function In People With Mild Cognitive Impairment (MCI), A Condition Of Higher-than-normal Memory And Thinking Difficulties For One's Age.

Care Partners Program for Alzheimer's Disease

Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.

In This Study, Researchers Will Develop And Test A Tailored, Tablet-based Program For Family Caregivers Of People With Alzheimer's Disease. The Program Will Combine An Evidenced-based Caregiver Intervention And Cognitive Training For The Person With Alzheimer's.

Caregiver Outcomes of Alzheimer's Disease Screening

Purpose: To measure the risks and benefits of early screening for Alzheimer's disease in terms of its effects on family caregivers.

This Randomized Controlled Trial Will Measure The Risks And Benefits Of Early Screening For Alzheimer's Disease In Terms Of Its Effects On Family Caregivers. Early Diagnosis Through Screening May Enhance The Family Member's Transition To Caregiving And Reduce Caregiver Burden By Providing An Opportunity For The Family Member To Learn About The Syndrome, Receive Interventions, And Prepare For The New Caregiving Role.

Cathodal Transcranial Direct Current Stimulation in MCI

Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.

This Study Is Evaluating the Application Of Cathodal Transcranial Direct Current Stimulation (tDCS) using An Investigational Device To Treat Mild Cognitive Impairment In Older Adults.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

This Clinical Trial Will Use Positron Emission Tomography (PET) Scanning To Measure The Clearance Of Waste From The Brain Via Cerebrospinal Fluid. The Objective Is To Determine The Role Of Impaired Clearance In The Buildup Of The Amyloid Protein In The Aging Brain And Risk For Alzheimer's Disease. A Harmful Form Of Amyloid Is Seen In The Brains Of People With Alzheimer's.

Cholinesterase Inhibitor Discontinuation

Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.

This Study Aims To Determine If Stopping Certain Medications For Alzheimer's Disease Will Cause Worsened Cognition, Functioning, Or Behavior In Veterans With Advanced Dementia Who Have Been Taking A CI (donepezil Or Galantamine) For At Least One Year.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

The COCOA Study Will Test The Effects Of 2 Years Of Coaching In Adults With Mild Cognitive Impairment (MCI) And Alzheimer's Disease. Researchers Believe That Providing Coaching, In Addition To Routine Care, May Improve Memory, Cognitive Function, And Quality Of Life.

Cognitive and Aerobic Resilience for the Brain (CARB)

Purpose: To test the impact of cognitive and/or exercise training on cognition in older adults with mild cognitive impairment.

This Trial Will Test The Impact Of Cognitive And/or Exercise Training On Cognition In Older Adults With Mild Cognitive Impairment (MCI).

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Behavioral Therapy (CBT) Is A Psychological Approach That Addresses The Interaction Between People's Thoughts, Feelings, And Behavior. This Study Will Test The Effects Of CBT compared With Usual Care In Reducing Stress Levels And Improving Cognitive Performance In African-American Adults With Mild Cognitive Impairment (MCI).

Cognitive Function in Adults With and Without HIV

Purpose: To better understand how the HIV virus affects the brain and cognitive aging.

This Study Will Test Two Different Drugs, Alone And In Combination, To Assess Their Effect On Cognitive Function In People With HIV As They Age. The Study Will Help Researchers Learn About The Contribution Of The Neuronal Cholingeric Receptor System To Cognitive Impairment In This Population.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

This Study Will Evaluate The Effects Of Cognitive Rehabilitation And Transcranial Electrical Stimulation (TES) On Cognitive Abilities In Adults Who Are Cognitively Normal Or Experiencing Cognitive Dysfunction.

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

This Study Will Evaluate The Effectiveness Of A Cognitive Rehabilitation Group Treatment For Veterans With Mild Cognitive Impairment (MCI).

Cognitive Training and Practice Effects in MCI

Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.

This Study Will Test The Effectiveness Of A Computerized Cognitive Training Program To Improve Thinking And Memory In People With Mild Cognitive Impairment (MCI).

Cognitive Training and Transcranial Direct Current Stimulation for HIV-Related Cognitive Dysfunction

Purpose: To test the effects of cognitive training and transcranial direct current stimulation on cognitive function in older adults with HIV-related cognitive dysfunction.

This Study Will Test The Effects Of Cognitive Training And Transcranial Direct Current Stimulation (tDCS) On Cognitive Function In Older Adults With Human Immunodeficiency Virus (HIV)-related Cognitive Dysfunction.

Cognitive Training to Improve Brain Function

Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.

In This Study, Researchers Will Measure The Potential For Cognitive Training To Improve Brain Function In Older Adults With And Without A History Of Mild Cognitive Impairment (MCI).

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

This Study Examines The Impact On Older Adults Of Learning The Results Of Amyloid Brain Imaging, Which Can Indicate Risk For Alzheimer's Disease. 

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

This Study Will Test The Efficacy Of Repetitive Transcranial Magnetic Stimulation (rTMS) As A Treatment For Older Adults With Mild Cognitive Impairment (MCI).

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

This Interview-based Study Compares Alzheimer's Disease caregiving In The United States And Mexico. The Goal Is To Identify Cross-cultural Differences In Order To Identify Strategies That May reduce The Burden Of The Disease On Family Caregivers. 

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

This Study Will Determine The Impact Of Two Interventions In People With Early Memory Problems. First, It Will Test the Clinical Benefits Of Curcumin, A Compound Isolated From turmeric Root, A component Of Indian Curry Spices That Has Been Found To Inhibit Several Potential Pathways In Alzheimer's Disease. Second, It Will determine The Effect Of adding A Yoga-based physical Exercise Program.

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

This Study Will examine The Feasibility Of Biochemical Assays, Genetic Testing, And Cognitive And Lifestyle Assessments In The Diagnosis Of Alzheimer's Disease, Mild Cognitive Impairment, And Other Neurodegenerative Diseases. The Study Also Aims To Assess Changes In Biological, Lifestyle, And Cognitive Assessments Collected From Individuals Over Time.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

This Study Will Test The Effects, Safety, And Tolerability Of Dapagliflozin, Also Known As Farxiga, In Adults With Mild To Moderate Alzheimer's Disease. Researchers Are Investigating Whether This Drug Can Slow Alzheimer's Disease.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

The Goal Of This Project Is To Identify Whether Carrying The APOE 4 Allele, the Strongest Genetic Risk Factor For Developing Alzheimer's Disease, Is Associated With Reduced Delivery Of DHA, An Omega-3 Fatty Acid, To The Brain in Cognitively Healthy Older Individuals. This Information Will Help Identify The Target Population That Could Benefit From DHA Supplementation To Prevent Cognitive Decline.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

This Study Will Examine The Effect Of Different Types Of Meals On Cognitive Function And Alzheimer's Biomarkers In Healthy Older Adults With And Without The APOE E4 Genotype. 

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

This Study Will Test Two Dietary Interventions In Overweight, Middle-aged Adults With Subjective Memory Complaints: A Powdered Berry Supplement And A Carbohydrate-restricted Diet Designed To Induce Ketone Metabolism.

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

The Study Will Explore The Effect Of Dietary Ketosis (a High-fat, Low-carbohydrate Diet Also Known As The Ketogenic Diet) On Adults With Early-stage Memory Loss And Metabolic Syndrome.

Dietary Treatments for Cognitive Impairment

Purpose: To study the effect on cognition of a modified Atkins diet in older adults with mild cognitive impairment or early Alzheimer's disease.

This Clinical Trial Will Test The Feasibility Of A Modified Atkins Diet (MAD) And Whether The MAD Results In Better Cognitive Test Scores Than A Placebo Diet In Older Adults With Mild Cognitive Impairment (MCI) Or Early Alzheimer's Disease Living In The Community.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

This Study Will Use A Variety Of Assessments And Clinical And Biological Measures To Characterize Adults With Three Different Disorders: Alzheimer's Disease, Lewy Body Dementia, And Parkinson's Disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

The Purpose Of This Study Is To Identify Potential Biomarkers That May Predict The Development Of Alzheimer's Disease In People Who Carry An Alzheimer's Mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

This Study Will Determine If The Alzheimer's Disease Drug Memantine Hydrochloride Can Improve Learning And Memory In Adolescents And Young Adults With Down Syndrome.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

This Trial Will Test The Safety And Efficacy Of Dronabinol (Marinol), A Medication Approved To Treat Chemotherapy-related Nausea And Vomiting And AIDS-related Lack Of Appetite, In Treating Agitation In Older Adults With Alzheimer's.

E2609 for MCI and Early Alzheimer's (Mission AD1)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, for The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

E2609 for MCI and Early Alzheimer's (Mission AD2)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, For The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Early-Onset Alzheimer's Disease Genomic Study

Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.

This Study Will Collect Samples From People With Early-onset Alzheimer's Disease And Their Immediate Family Members to Better Understand How Changes In The Body Are Related To Development Of The Disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

This Study Will Test An Education And Skills-based Training Program For People With Early-stage Memory Loss Or Dementia And Their Care Partners. The Training Is Designed To Reduce Stress And Distress, And Increase Well-being And Quality Of Life.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

This Study Will Test The Hypothesis That The Presence Of Beta-amyloid Plaques In The Braina Hallmark Of Alzheimer's Diseasein Non-demented Older Patients Increases The Likelihood Of cognitive Decline After scheduled Hip Or Knee Replacement Surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

This Study Will Examine The Sensitivity Of Functional Magnetic Resonance Imaging (fMRI) To Detect Brain Changes In Healthy Older Adults At Genetic Risk For Alzheimer's Disease Who Take The Drug Donepezil (Aricept). Participants With A Family History Of Alzheimer's Are Eligible For This Study. Participants Without A Family History Of Alzheimer's Can Be enrolled To Serve As A Control Group.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

This Study Will Evaluate The Safety And Efficacy Of Escitalopram (Lexapro) To Treat Agitation In Alzheimer's Disease.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

The EASES Study Is A 2-year Observational Study Designed To Measure Brain Function During The Onset And Progression Of Mild Cognitive Impairment (MCI) In Older Adults using Quantitative Electroencephalography (qEEG).

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Physical Inactivity, High Blood Pressure, And High Cholesterol Levels Are Risk Factors For Alzheimer's Disease And Vascular Dementia; However, These Risk Factors Are Modifiable With Lifestyle Changes And Medications. This Study Will Test The Effects Of Aerobic Exercise And Vascular Risk Reduction On Cognitive Performance In Older Adults Who Are At Risk For Alzheimer's Disease.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

This Study Is Recruiting Older Adults Who Are Cognitively Healthy But Physically Inactive to Participate In An Intervention Comparing Aerobic Exercise And Flexibility Exercise And Their Effects On Memory And Brain Function.

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

This Study Evaluates The Effects Of Physical Exercise On Cognition, Functional Status, Brain Atrophy, Blood Flow, And Cerebrospinal Fluid Biomarkers Of Alzheimer's Disease In Adults With A Mild Memory Impairment. Half Of Participants Will Participate In A Stretching-balance-range Of Motion Exercise Program, While The Other Half Will Participate In A Moderate- To High-intensity Aerobic Training Program.

Family Telemental Health Intervention for Veterans with Dementia

Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.

This Research Project Will Develop A Telehealth Intervention To Address Interpersonal Difficulties Between Caregivers And Persons With Dementia In Families With Veterans.

GRF6019 Infusions for Severe Alzheimer's Disease

Purpose: To evaluate the safety, tolerability, and potential cognitive benefit of the experimental treatment GRF6019 in older adults with severe Alzheimer's disease.

This Phase II Study Will Evaluate The Safety, Tolerability, And Potential Cognitive Benefit Of An Intraveneous Infusion Of GRF6019, A Plasma-derived Product, To Treat Older Adults With Severe Alzheimer's Disease.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

This Phase III Clinical Trial Will Evaluate The Efficacy And Safety Of Gantenerumab In People with Early-stage Alzheimer's Disease. Gantenerumab is An Experimental Medication That Is Being Investigated For Its Ability To Reduce Beta-amyloid Plaques In The Brain That Are associated With Alzheimer's Disease. This Trial Is Similar To Safety And Efficacy Of Gantenerumab For Early Alzheimer's, But Recruiting In Different Locations.

GeneMatch

Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

The GeneMatch Program, Part Of The Alzheimer's Prevention Registry, Aims To Identify People Interested In Participating In Research Studies Or Clinical Trials Based In Part On Their Genetic Background. GeneMatch Will Collect Genetic Information From Participants Which May Be Used To Match Them To Studies. Participants Are Under No Obligation To Pursue These Study Opportunities.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

This Long-term Study Will Help Researchers Learn More About Biomarkerssubstances In Human Blood And Tissuesand Their Relationship To Aging. The Goal Is To Find Ways To Improve Quality Of Life In Old Age.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

In This Observational Study, Scientists Will Examine The Genes Of Families With A History Of Movement Disorders (such As Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Ataxia, Corticobasal Degeneration, Dystonia, Essential Tremor, And Huntington's Disease) And Dementias (such As Alzheimer's Disease, Lewy Body Dementia, And Frontotemporal Dementia) To Try To Find a Genetic Cause Of These Disorders. People With Any Movement Disorder Or Dementia And Their Family Members Are Invited To Participate.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

This Exploratory Trial Will Investigate The Effects Of A Glutathione Dietary Supplement On Cognitive Function In Adults With Mild Cognitive Impairment (MCI).

Grape Seed Extract for Alzheimer's Disease

Purpose: To establish the safety and pharmacokinetics of grape seed extract and to test its cognitive effects in people with Alzheimer's disease.

This Phase II Clinical Trial Will Establish The Safety And Pharmacokinetics Of A Grape Seed Extract, Meganatural-Az, And Test Its Effects On Cognition In People With Alzheimer's Disease. This Extract Is Thought To Act On Tau Tangles, A Protein Accumulation Seen In The Brain Of People With Alzheimer's.

Home Visits for Progressive Supranuclear Palsy and Related Disorders (CarePSP)

Purpose: To test a home visit program designed to assess the needs of people with progressive supranuclear palsy (PSP) or related disorders and to connect them with services.

This Study Will Test A Home Visit Program Designed To Assess The Needs Of People With Progressive Supranuclear Palsy Or Related Disorders And to Connect Them With Services.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

This Study Will Test The Ability Of The Radioactive Tracer 11C-ER176 To Stick To Parts Of The Brain Where There Is Inflammation. Past Studies Have Shown That Inflammation Is Present In The Brains Of People With Alzheimer's Disease.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

This Study Will Test Dance And Social Engagement As A Method To Decrease Behavioral Symptoms And Improve Quality Of Life In Older Adults With Mild Cognitive Impairment (MCI) Or Early Alzheimer's Disease.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

This Study Uses Mobile Health Devices To Help Physically Inactive, Cognitively Normal Older Adults Walk, With The Aim Of Preserving Cognitive Function.

Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE)

Purpose: To test the effect of a telephone-based intervention on reducing the burdens of dementia-associated symptoms and behaviors.

The 2-year IN-PEACE Study Is Recruiting Patient-caregiver Pairs To Help Test A Telephone-based Intervention Involving Regular, Proactive Contact By A Dementia Care Coordinator To Anticipate And Identify Patients' Symptoms And Caregivers' Needs And Help Address Those Needs.

Insulin Aspart to Fight Forgetfulness

Purpose: To test the effects of fast-acting intranasal insulin on cognition and daily function in people with Alzheimer's disease or mild cognitive impairment.

This Phase I Clinical Trial Will Test The Effects Of Fast-acting Intranasal Insulin On Cognition And Daily Function In People With Alzheimer's Disease Or Mild Cognitive Impairment. Researchers Will Also Examine Markers Of Alzheimer's In Blood And Cerebrospinal Fluid And Amyloid Deposition In The Brain.

Insulin Resistance and Accelerated Cognitive Aging

Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.

This Observational Study Will Track Cognitive And Neural Biomarkers In People Younger Than 50 Who Are Overweight Or Obese And Have Metabolic Risk Factors Associated With Cognitive Decline Later In Life.

Intermittent Calorie Restriction, Insulin Resistance, and Brain Function

Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.

In This Study, Researchers Will Investigate How Diet Affects Insulin Resistance, Weight, And Brain Chemicals Related To Alzheimer's Disease. Specifically, They Will Compare Two Forms Of Diet And Their Effects On Insulin Resistance And The Brain.

Internet-Based Conversational Engagement for Socially Isolated Older Adults (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face Web-based conversations could improve cognitive function in older adults who are socially isolated.

This Study Will Test The Effects Of Regular Web-based Conversations On Cognitive Function In Adults Over 80 Who Are Socially Isolated.

Interventions for Circadian Rhythm Disorders in Dementia (Healthy Patterns Sleep Study)

Purpose: To evaluate a program of activities to improve symptoms of disturbed sleep-wake cycles in people with dementia who live at home.

This Phase III clinical Trial Will Evaluate A 1-month, 8-session Program For Caregivers That Provides Instruction In Activities To Improve Symptoms Of Disturbed Sleep-wake Cycles In  People with Dementia Who Live At Home.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

Researchers Are Looking For Adults Who Are Diagnosed With Frontotemporal Dementia, A Motor Neuron Disorder, Or A Related Adult-onset Neurodegenerative Disorder To Participate In Ongoing Research Or Be Considered For Future Studies.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

This Trial Will Test The Effects Of 12 Months Of Walking exercise On Cognitive Performance, Brain Structure And Function, And Other Biological Measures In Older Adults Who Are Cognitively Normal.

LY3002813 and LY3202626 for Early Alzheimer's Disease (TRAILBLAZER-ALZ)

Purpose: To evaluate the safety, tolerability, and efficacy of the investigational drugs LY3002813 and LY3202626 in older adults with early symptomatic Alzheimer's disease.

TRAILBLAZER-ALZ Aims to Evaluate The Safety, Tolerability, And Efficacy Of The Investigational Drug LY3002813 Alone And In Combination With LY3202626 In Early Symptomatic Alzheimer's Disease.

LY3303560 for Early Symptomatic Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of experimental drug LY3303560 in people with early-stage Alzheimer's disease.

This Study Will Evaluate The Safety And Efficacy The Experimental Drug LY3303560 In People With Early-stage Alzheimer's Disease. 

LY3372993 in Healthy Participants and People with Alzheimer's

Purpose: To evaluate the safety and tolerability of the investigational drug LY3372993 in healthy adults and older adults with Alzheimer's disease.

This Phase I Study Will Test The Safety And Tolerability Of The Investigational Drug LY3372993 In Healthy Adults And Older Adults With Alzheimer's Disease. 

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

The Purpose Of This Study Is To Further Define The Neurological And Linguistic Deterioration In Primary Progressive Aphasia.

Levetiracetam for Alzheimer's Disease-Associated Epileptiform Activity

Purpose: To test the use of levetiracetam, an anticonsulvant, to control seizures in people with Alzheimer's disease.

This Study Will Test The Use Of Levetiracetam (Keppra), An Approved Treatment For Epilepsy, To Control Seizures In People With Alzheimer's Disease. Many People With Alzheimer's Have Seizures And Other Overactive Electrical Activity In The Brain That Is Not Noticeable But May Contribute To The Loss Of Cognitive Function. 

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

This Study Will Examine The Effects Of Exercise And Healthy Living Education On Brain Health, Cognition, And Physical Function In Older Adults With Cognitive Concerns.

Light and Cognitive Therapy for Alzheimer's Disease

Purpose: To test an iPad app that delivers light therapy at 40 Hz, combined with cognitive therapy, to improve cognition in people with Alzheimer's.

This Observational Study Will Test The Ability Of An IPad App to Improve Cognition, Function, And Quality Of Life In People With Alzheimer's Disease. The App Delivers Light Therapy At 40 Hz While Users Play Cognitive Games.

Light for Metabolic Syndrome and Alzheimer's

Purpose: To test the effects of a tailored lighting system on sleep, mood, inflammation, and glucose tolerance in older adults with Alzheimer's disease or a related dementia and type 2 diabetes.

This Study Will Test The Effects Of A Tailored Lighting Intervention On Mood, Behavior, And Factors Associated With Metabolic Syndrome In People Living In A Controlled Environment, Such As A Nursing Home Or Assisted Living Facility, With Mild To Moderate Alzheimer's Disease Or A Related Dementia And Type 2 Diabetes.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

The Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) Is A 2-year Observational Study Designed To Look At Disease Progression In Adults With Early-onset Alzheimer's Disease. Researchers Are Also Recruiting Cognitively Normal Volunteers For A 1-year Comparison.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

The Purpose Of This Study Is To Learn About Thinking And Behavior In Families In Which One Or More Relatives Has A Genetic Mutation Associated With Frontotemporal Dementia.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Obesity Is Associated With A Higher Risk Of Health Problems, Including Heart Disease, Hypertension, And Diabetes, And May Be A Risk Factor For Cognitive Decline And Dementia. This Study Will Test The Effects Of A Mediterranean Diet And Caloric Restriction To Promote Weight Loss And Improve Cognitive Function In Obese Older Adults.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

Nicotine Has Been Shown To Improve Attention, Learning, And Memory. Researchers In This Phase II Trial Will Test Whether Nicotine Delivered Via A Transdermal (skin) Patch May Improve Memory Performance In Older Adults Who Are Experiencing Mild Cognitive Impairment (MCI).

Methylation Diet and Lifestyle Changes in Older Adult Men

Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.

This Study Will Evaluate A 9-week Diet And Lifestyle Intervention In Healthy Older Adult Men To Test whether Short-term Changes Can Affect DNA Methylation. Methylation Is an Epigenetic Change That Affects The Way Genes Function And Has Been Associated With Dementia And Other Conditions, Including Diabetes And Cancer. 

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

This Observational Study Will Examine Changes In brain-region Size, Shape, And Activity That Occur In Women With Breast Cancer And How Those Changes Relate To The Development Of Mild Cognitive Impairment. Three Groups Will Be Compared: Women With Breast Cancer Who Will Undergo Hormonal Therapy With Or Without Chemotherapy, Women With Breast Cancer Who Will Undergo No Therapy Or Radiation Therapy, And Healthy Female Volunteers.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

MindCrowd Is A Web-based Memory Study Designed To Analyze How Genetics Influences Memory. Participants Age 18 Or Older Are Invited To Take A 10-minute Online Test. For More Information, Visit www.mindcrowd.org.

Mindfulness-Based Stress Reduction, Health Education, and Exercise

Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.

This Study Will Examine The Effects On Age-related Cognitive Decline Of Mindfulness-based Stress Reduction (MBSR), Aerobic Exercise, And Their Combination, Compared With A Health Discussion Group.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

The Modified Story Memory Technique (mSMT) Cognitive Retraining Program Has Been Shown To Improve new Learning And Memory Function in Individuals With Multiple Sclerosis And Traumatic Brain Injury. This Study Will Measure The Effects Of MSMT In Cognitively Healthy Older Adults And Adults With Mild Cognitive Impairment. Researchers Will Determine whether Engaging In MSMT Can Enhance Memory And Learning Ability.

Movement and Music for Older Adults with Dementia

Purpose: To learn about the possible benefits of movement and music in older adults with dementia.

This Study Will Investigate How Participating In A Dance Class Or Listening To Music Affects Mobility And/or Cognition In Older Adults With Dementia.

Multicultural Healthy Diet to Reduce Cognitive Decline

Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.

This 18-month Trial Is Designed To Investigate Whether The Multicultural Healthy Diet, An Anti-inflammatory Diet Tailored To A Multicultural Population, Can Improve Cognitive Functioning In Urban-dwelling Adults.

Multidimensional Behavioral Intervention for Adults with Cognitive Concerns (BBLite)

Purpose: To promote use of compensation strategies, organization systems, and brain health activities in older adults with concerns about their memory and cognitive function.

This Study Will Test The Effectiveness Of A Multidimensional intervention to Enhance skills Related To Everyday Activities In Adults With Concerns About Their Memory Or Cognitive Function, As Well As engagement In Healthy Lifestyle Activities To Further Promote Brain Health.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

This Study Will Test A 10-week Intervention Designed To Promote Use Of Compensation Skills And Organization Systems and Increased Engagement With Brain Health Activities In Older Adults With Subjective Cognitive Concerns.

Multidirectional Yoga for Cognition

Purpose: To explore the effects of a new yoga intervention on cognitive function in older adults.

This Study Will Test A Yoga Intervention in Cognitively Normal Older Adults To Gauge Its Effects On Cognitive Function And Associated Movements.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

This Phase II Trial Will Explore The Effects Of Music Training On Central Auditory Processing, Cognition, And Everyday Function Among Older Adults With And Without Mild Cognitive Impairment.

NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's

Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.

This Phase 1 Trial Will Test An Experimental Drug, NDX-1017, in Healthy Adults And People With Mild Alzheimer's Disease To Evaluate Safety, Dosing, And Action Of The Drug.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

In This Observational Study, Researchers Will Document The Clinical Features And Biological Markers Of People With Synucleinopathies (Parkinson's Disease, Dementia With Lewy Bodies, Or Multiple System Atrophy) And Those In A Pre-dementia Stage To Better Understand How These Disorders Evolve Over Time.

Neflamapimod for MCI or Mild Alzheimer's Disease

Purpose: To test the effects of the investigational drug neflamapimod on memory and cognitive function in older adults with mild cognitive impairment or mild Alzheimer's disease.

This Phase 2 Study Will Test The Effects Of The Investigational Drug Neflamapimod, Also Known As VX-745, On Memory And Cognitive Function In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Neural Basis of Frontotemporal Degeneration and Related Disorders

Purpose: To study adults with frontotemporal degeneration, multiple systems atrophy, and progressive supranuclear palsy to better understand the causes of these disorders.

This Observational Study Aims To Better Understand The Causes Of Frontotemporal Degeneration (FTD), Multiple Systems Atrophy (MSA), And Progressive Supranuclear Palsy (PSP) To Help Improve Diagnosis And Develop Future Treatments.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nicotinamide, Or Niacinamide, Is A Form Of Vitamin B3 That Researchers Are Exploring For Its Possible Use In Reducing tau, A Protein That Accumulates In Tangles In The Brain's Of People With Alzheimer's Disease. This Study Will Test The Effects Of A High Dose Of Nicotinamide In Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nighttime Agitation Causes Distress For People With Alzheimer's And Their Caregivers. Previous Research Has Identified A Possible connection Between Restless Legs Syndrome (RLS) And Nighttime Agitation And Sleep Disturbance In People With Alzheimer's. In This Study, Researchers Will Explore Whether RLS May Be A Cause Of Nighttime Agitation And if An Approved Treatment For RLS, Horizant (gabapentin Enacarbil), Reduces Or Stops Agitation And Improves Sleep. 

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

This Observational Study Seeks To Better Understand The Experience And Needs Of Older Adults With Mild Cognitive Impairment (MCI) Or Alzheimer's Disease who Live Alone.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Optimizing Dementia Care for Veterans and Their Caregivers

Purpose: To examine the effectiveness of an established counseling approach and a variation of it for veterans with dementia and their family caregivers who have high levels of stress. 

This Study Will Compare Care Consultation With A More Intensive Variation Of It For Veterans With Dementia And Their Family Caregivers Who Are Experiencing High Levels Of Stress. Researchers Will Compare The Impact Of The Intervention On Quality Of Life, Care Burden, And Other Factors. Care Consultation Is An Established, Telephone-based Intervention That Uses Coaching And Emotional Support To Help Family Caregivers And Individuals With Dementia Through Education, Resource Referral, Psychosocial Support, And Encouragement To Use Services.

Optimizing Postoperative Cognition in the Elderly

Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.

Investigators Will Compare Brain-wave Patterns In Older Patients Who Have Memory And Thinking Problems After Surgery With Brain-wave Patterns In Patients Without Such Problems.

Palliative Care for Parkinson's and Related Disorders

Purpose: To compare usual care to palliative care for adults with Parkinson's disease and related disorders.

For Individuals With Chronic, Progressive Illnesses, Palliative Care Addresses Potential Causes Of Suffering, Including Physical And Psychiatric Symptoms, Psychosocial Issues, And Spiritual Needs. This Study Will Compare Usual Care In The Community To Care Augmented By Palliative Training And Telemedicine Support For People With Parkinson's Disease And Related Disorders, Including Progressive Supranuclear Palsy, Corticobasal Degeneration, Multiple System Atrophy, And Lewy Body Dementia.

Performing Arts for Alzheimer's Dementia Caregivers

Purpose: To examine whether a performing arts class will improve the well-being of primary unpaid caregivers of people with Alzheimer's dementia.

This Study Will Examine The Effect Of A Performing Arts Class On Improving The Well-being Of Caregivers Of Older Adults With Alzheimer's Dementia.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

This Research Will Examine The Effect On Cognition Of Increasing Physical Activity Using A Body-worn Sensor. Older Adults Will Be Asked To Increase Physical Activity For 12 Weeks While Wearing A Sensor Attached To A Belt That Will Monitor Activity.

Pimavanserin for Relapse of Dementia-Related Psychosis

Purpose: To evaluate the efficacy of the drug pimavanserin (Nuplazid) in preventing a relapse of psychotic symptoms in adults with who were previously stabilized after 12 weeks of treatment.

This Phase III Study Will Test The Drug Pimavanserin (Nuplazid) for Preventing A Relapse Of Psychotic Symptoms, Such As Hallucinations And Delusions, In Adults With Dementia Who Were Previously Stabilized After 12 Weeks Of Treatment.

Piromelatine for Mild Alzheimer's Disease (ReCOGNITION)

Purpose: To test the safety and efficacy of the experimental drug piromelatine in people with mild Alzheimer's dementia.

This Phase II Clinical Trial Will Test The Safety And Efficacy Of The Experimental Drug Piromelatine In People With Mild Alzheimer's Dementia.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen^® in older adults with early-stage Alzheimer’s disease.

This Phase I Trial Will Evaluate The Safety, Pharmacokinetics, And Efficacy of Three Different Doses Of The Experimental Drug Posiphen In Older Adults With Early-stage Alzheimer's Disease.

Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)

Purpose: To evaluate a mindfulness-based intervention for caregivers of people with dementia.

This Study will Evaluate The Effectiveness Of A Mindfulness-based Caregiver Intervention That Is Designed To Improve The Caregiver's Burden And The Care Recipient's Quality Of Life. Care Recipients Have Alzheimer's Disease Or A Related Dementia.

Pragmatic Trial of Video Education in Nursing Homes (PROVEN)

Purpose: To test the use of a video about advance care planning for nursing home residents.

This Study Will Test Whether Watching A Video About Advance Care Planning For Nursing Home Residents Makes A Difference In Hospitalizations, Presence Of Advance Directives, And Hospice Care Compared With Residents Who Follow The Usual Advance Care Planning Procedures.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

Mild Traumatic Brain Injury (TBI) From Explosions Is A Common Injury Of Veterans, And Multiple mild TBIs Can lead To Chronic Traumatic Encephalopathy (CTE) And Alzheimer's Disease Years Later. This Study Will Test The Approved Drug Prazosin In Veterans Who Have Experienced Mild TBIs To Explore Its Effects On Biomarkers Of These Diseases. 

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

This Study Will Examine How Different Types Of Training Activity Affect Older Adults' Cognitive Function, Brain Structure, Biomarkers Of Brain Health And Cognition, And Physical Function. In Addition, The Study Will Assess How An Individual's Cognitive And Physical Characteristics Influence Their Responsiveness To Each Type Of Training Activity.

Preventing Loss of Independence Through Exercise in Mild Cognitive Impairment (PLIE)

Purpose: To test an exercise program in older adults with mild cognitive impairment.

This Randomized, Controlled Trial Will Test The An Exercise Program In Older Adults With mild Cognitive Impairment (MCI) Who Live In The Community.

Program for African American Cognition and Exercise (PAACE)

Purpose: To develop and evaluate a program to increase physical activity and improve cognitive function in African-American older adults who are sedentary.

The PAACE Study Is Designed To Develop A Physical Activity Program For African-American Older Adults Who Are Sedentary To Improve Cognition And Brain Health.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

People With Mild Cognitive Impairment (MCI) Have Memory Deficits But Remain Relatively Independent In Everyday Life. This Study Will Determine If Noninvasive Brain Stimulation Can Enhance Functioning In Specific Brain Regions And Networks, Increasing Participants' Ability To Benefit From Memory Rehabilitation.

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

This study Will Investigate Pupillary Light Response As A Potential Detection Method For progressive Supranuclear Palsy (PSP) In Adults With PSP Or Other Neurodegenerative Diseases.

RO7105705 for Prodromal to Mild Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the experimental drug RO7105705 in people with prodromal to mild Alzheimer's disease.

This Phase II Study Will Evaluate The Efficacy And Safety Of An Experimental Drug, RO7105705, In People With Prodromal (early) To Mild Alzheimer's Disease.

Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia

Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.

This Study Is Designed To Remediate Word-finding Problems In People With Primary Progressive Aphasia (PPA) And To Delay Further Progression Of Word-finding Impairment.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Researchers Will Use Magnetic Resonance Imaging (MRI) To Investigate Brain Function And Connections In Healthy Adults. This Might Help People With Brain Diseases In The Future.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

This Study Will Explore The Effect Of Consultation Sessions On Reducing Distress And Strain In Family Caregivers Who Have Transitioned A Cognitively Impaired Relative To Long-term Care.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Riluzole, A Drug Used To Slow Down The Progress Of Amyotrophic Lateral Sclerosis (ALS), Will Be tested In People With Mild Alzheimer's Disease. Cognitive Functional Changes And Specific Imaging Biomarkers Will Be Evaluated.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

This Study Plans To Establish A Large Bank Of Blood, Cerebrospinal Fluid, Imaging, And Clinical Data To Be Used In Alzheimer's Disease Research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

This Phase I study Will Investigate The Role Of The Nicotinic System In The Brain, A Subset Of The Cholinergic System, On Memory And Thinking And Healthy Aging By Using Stimulants And Blockers To Examine Brain Activation Patterns.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

S-equol Is A Compound That Acts Like Estrogen In The Body And Is Available As An Over-the-counter Supplement. In This Study, Researchers Will Test The Safety And Tolerability Of A Therapeutic Dose Of S-equol And Its Effects On Cognition In Adults With Alzheimer's Disease.

SPIRIT for End-of-Life Decision Making in Mild Alzheimer's

Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild Alzheimer's disease and their surrogates to promote end-of-life care discussions.

This Study Will Test An Advance Care Planning Intervention Called Sharing Patient's Illness Representations To Increase Trust, Or SPIRIT, For People With Mild Alzheimer's Disease And Their Surrogates To Promote Early Discussions About End-of-life Care.

Safety and Efficacy of Gantenerumab for Early Alzheimer's

Purpose: To evaluate the safety and efficacy of the investigational drug gantenerumab in people with early Alzheimer's disease.

This Phase III Clinical Trial Will Evaluate The Safety And Efficacy Of Gantenerumab In People With Early-stage Alzheimer's Disease. This Trial Is Similar To Gantenerumab For Early Alzheimer's Disease, But Recruiting In Different Locations.

Salsalate for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and tolerability of twice daily salsalate in adults with mild to moderate Alzheimer's Disease.

The Purpose Of The Study Is To Test The Safety And Tolerability Of Twice Daily Salsalate, A Nonsteroidal Anti-inflammatory Drug (NSAID), In Adults With Mild To Moderate Alzheimer's Disease.

Self-Management of Chronic Pain and Negative Emotions

Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.

This 24-week Pilot Study Will Test The Effects Of Problem Adaptation Therapy For Pain, Or PATH-Pain, In Helping To Reduce Negative Emotions And Pain In Older Adults Who Are Cognitively Normal Or Have Mild Cognitive Impairment.

Sensory Stimulation to Improve Brain Function (Overture Study)

Purpose: To study the effects of an auditory and visual sensory stimulation system on older adults with mild cognitive impairment and Alzheimer's disease.

The Overture Study Is A Phase I/II Clinical Trial To Study Safety, Adherence Rates, And Efficacy Of The Active GammaSense Stimulation System In Older Adults With Mild Cognitive Impairment (MCI) And Alzheimer's Disease. The Device Provides Noninvasive Auditory And Visual Sensory Stimulation To The Brain.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

This Study Of Aging And The Brain Is Looking For Healthy Older Adults To Participate In Brain Imaging, Genetic Testing, Memory Testing, And Analysis Of Proteins In The Blood And Spinal Fluid. The Goal Is To Develop Biological Markers To Aid In Better Understanding, Early Detection, And Treatment Of Alzheimer’s Disease.

Stem Cell Infusion for Alzheimer's Disease

Purpose: To test the safety and efficacy of a stem-cell infusion to treat people with Alzheimer's disease.

This Phase I Trial Will Test The Safety And Efficacy Of An Infusion Of Longeveron Mesenchymal Stem Cells (LMSCs) To Treat people With Alzheimer's Disease. Mesenchymal Stem Cells Have Been Found To Counteract The Neuroinflammation That Contributes To The Progression Of Alzheimers Disease.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

This Study Will Test The Effects Of Strawberry Powder On Cognition And Mobility In Cognitively Normal Obese Older Adults.

TRx0237 for Mild Alzheimer's

Purpose: To determine the safety and efficacy of the investigational treatment TRx0237 in older adults with mild Alzheimer's disease.

This Phase II/III Study Will Test The Safety And Efficacy Of The Investigational Drug TRx0237, Also Known As LMTX, In Older Adults With Mild Alzheimer's Disease.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

This Study Will Use The New Radioactive Tracer 18F-MK-6240 In Positron Emission Tomography (PET) Scanning To Detect Tau Pathology In Older Adults Who Are Cognitively Healthy And Mildly Cognitively Impaired.

Tau PET Imaging Using 18F-AV-1451

Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.

This Study Will Evaluate A New Radioactive Compound, 18F-AV-1451, In Identifying Tau Tangles In Positron Emission Tomography (PET) Scans. Tau Is A Protein That Accumulates Abnormally In The Brains Of People With Alzheimer's Disease And Other Neurodegenerative Disorders.

Tele-Savvy Education Program for Dementia Caregivers

Purpose: To test an Internet-based education program for dementia caregivers.

This Study Is Testing An Internet-based Education Program For Caregivers Of People With Alzheimer's Or Another Dementia.

Telmisartan to Prevent Alzheimer's in African Americans

Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.

This Study Is Designed To Determine If Telmisartan (Micardis), An Approved Medication For High Blood Pressure, May Help Prevent Alzheimer's Disease In African Americans, A Group At Relatively High Risk For Developing Alzheimer's.

Training to Reduce Care-Resistant Behaviors in Alzheimer's and TBI (NeuroNS-Care)

Purpose: To test a distance-learning training program for family caregivers of people with Alzheimer's or TBI in reducing care-resistant behaviors.

This Study Will Test The Effectiveness Of An Internet-based Distance-learning Program In Reducing Care-resistant Behaviors, Including Agitation, Aggression, And Irritability, In People With Alzheimer's Disease Or Traumatic Brain Injury (TBI).

Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance

Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.

This Study Will Investigate The Effect Of Transcranial Alternating Current Stimulation On Sleep And Cognitive Performance In Cognitively Normal Older Adults And In Individuals With Mild Cognitive Impairment (MCI).

Transcranial Direct Current Stimulation and Language Therapy for Primary Progressive Aphasia

Purpose: To investigate the effects of transcranial direct current stimulation (tDCS) and language therapy on adults with PPA.

Primary Progressive Aphasia (PPA) Is A Neurodegenerative Disease That Is Characterized By The Gradual Loss Of Language Functioning. This Study Will Test The Effects Of Multiple Consecutive Transcranial Direct Current Stimulation (tDCS) Sessions Paired With Language Therapy In Adults With PPA.

Transcranial Direct Current Stimulation for Mild Cognitive Impairment

Purpose: To explore transcranial direct current stimulation as a way to improve word finding and memory retrieval in adults with mild cognitive impairment.

This Study Will Test The Effects Of High-definition Transcranial Direct Current Stimulation (tDCS) On Improving Word Finding And Memory In Adults With Mild Cognitive Impairment.

Transcranial Direct Current Stimulation for Primary Progressive Aphasia

Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.

This Study Will Test The Effects Of Transcranial Direct Current Stimulation (tDCS) During Language Therapy In People With Primary Progressive Aphasia (PPA), A Neurodegenerative Disease That Affects Language Abilities. Investigators Will Assess If This Intervention Is More Effective Than Language Therapy Alone. They Will Also Assess Changes In Functional Brain Connectivity Associated With TDCS.

Transcranial Magnetic Stimulation and Magnetic Resonance Imaging for Diagnosing Preclinical Dementia

Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.

This Study Will Explore The Use Of Transcranial Magnetic Stimulation (TMS) Integrated With Functional Magnetic Resonance Imaging (fMRI) For Diagnosing Preclinical Dementia. This Research Will Support Development Of A More Sensitive Diagnostic Tool For Dementia.

Transcranial Magnetic Stimulation for Apathy in MCI

Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.

In This Multi-phase Study, Researchers Are Investigating The Effects Of Transcranial Magnetic Stimulation (TMS) On Motivation, Memory, And Function In Older Veterans With Mild Memory Problems.

Transcutaneous Vagal Nerve Stimulation for MCI

Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.

This Study Will Test The Effects Of An Experimental Treatment, Transcutaneous Vagal Nerve Stimulation (tVNS), On Cognitive Performance And Memory In Older Adults With Mild Cognitive Impairment (MCI).

Treatment of Psychosis and Agitation in Alzheimer's Disease

Purpose: To test lithium as a treatment for psychosis and agitation in older adults with Alzheimer's disease.

This Phase II Clinical Trial Will Test Low-dose Lithium As A Treatment For Psychosis And Agitation In Older Adults With Alzheimer's Disease. Currently, There Is No Federally Approved Medication For The Treatment Of Psychosis Or Agitation In Alzheimer's. Safety, Side Effects, And Efficacy Will Be Evaluated.

Types of Progressive Apraxia of Speech

Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.

This Observational Study Aims To Identify And Distinguish Two Different Types Of Progressive Apraxia Of Speech (PAOS), A Disorder Associated With Neurodegenerative Disease And Dementia, Through Clinical Imaging And Testing Of Adults With PAOS.

VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

The Purpose Of This Study Is To Study The Effects Of An Education And Skill-building Intervention On Family Caregivers Of Veterans With Dementia.

VU319 in Healthy Adult Volunteers

Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.

This Phase I Trial Of The Experimental Drug VU319, Developed To Improve Cognitive Function In People With Alzheimers, Will Study Its Effects in Healthy Adults.

Valacyclovir for Mild Alzheimer's Disease

Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.

This Phase II Study Will Test The Efficacy Of The Anti-viral Drug Valacyclovir (Valtrex) In Treating Adults With Mild Alzheimer's Disease Who Also Test Positive For Herpes Simplex Virus-1 (HSV-1) Or HSV-2.

Water-based Activity to Enhance Recall in Veterans (WATER-VET)

Purpose: To evaluate the feasibility of a water-based exercise program with cognitive training to improve memory in veterans with mild cognitive impairment.

This Study Will Evaluate The Feasibility Of A Water-based Exercise Program, Along With A Cognitive Training Intervention, To Improve Memory In Veterans With Amnestic (memory-related) Mild Cognitive Impairment (aMCI). 

Weighted Blankets to Decrease Agitation in Dementia

Purpose: To evaluate whether weighted blankets can reduce agitation in hospitalized patients with dementia.

This Clinical Trial Will Evaluate Whether Weighted Blankets Can Reduce Agitation And Aggressive Behaviors In Hospitalized Patients With Dementia.

Yoga and Meditation for Reducing Alzheimer's Risk in Women with MCI

Purpose: To test the effects of kundalini yoga and kirtan kriya yogic meditation, in comparison to memory training, in improving cognitive function, health, and mood in older adult women with mild cognitive impairment.

The Purpose Of This Pilot Study Is To Test The Effects Of Kundalini Yoga And Kirtan Kriya Meditation, In Comparison To Memory Training, On Cognitive Function, Health, And Mood In Older Adult Women With Mild Cognitive Impairment (MCI).