Clinical Trials Search Result

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

ACI-24 Vaccine in Adults with Down Syndrome

Purpose: To test the ACI-24 vaccine in adults with Down syndrome.

AD-35 for Mild to Moderate Alzheimer's

Purpose: To evaluate the safety, tolerability, efficacy, and behavior of AD-35 in older adults with mild to moderate Alzheimer's disease.

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

AL001 for Frontotemporal Dementia in Healthy Volunteers and People with FTD

Purpose: To assess the safety, tolerability, and behavior of the drug AL001 in healthy adult volunteers and people with frontotemporal dementia and the granulin mutation.

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

AR1001 for Mild to Moderate Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of AR1001 in people with mild to moderate Alzheimer's disease.

AVP-786 for the Treatment of Agitation in Alzheimer's

Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.

AXS-05 for Agitation in Alzheimer's

Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Aging-Well: Remote Monitoring for Adults at Risk for Alzheimer's Disease

Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.

Alzheimer Prevention Trials (APT) Webstudy

Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

Alzheimer's Disease, Caregiving, and Social Networks

Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.

Alzheimer's Disease Genetics Study

Purpose: To identify the genes that cause late-onset Alzheimer's disease.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

Amyotrophic Lateral Sclerosis (ALS) Families Project

Purpose: To learn how and why motor neuron degeneration begins and progresses in families affected by familial amytrophic lateral sclerosis (ALS).

Antidepressants to Prevent Mild Cognitive Impairment

Purpose: To test two antidepressants in people with subjective cognitive impairment.

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)

Purpose: To test methylphenidate (Ritalin^®) as a treatment for clinically significant apathy in people with Alzheimer's disease.

Assessing J147 for Alzheimer's in Healthy Volunteers

Purpose: To assess the safety, tolerability, and pharmacokinetics of the investigational drug J147 in healthy young and older adults.

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

Azeliragon for Mild Alzheimer's and Diabetes (Elevage)

Purpose: To evaluate the efficacy and safety of the investigational drug azeliragon in adults with mild Alzheimer's disease and impaired glucose tolerance.

BAN2401 for People with Early Alzheimer's Disease

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

BIIB092 in Primary Tauopathies

Purpose: To test the safety, tolerability, and effects of the investigational drug BIIB092 in people with one of four different tauopathy syndromes.

Biomarker Predictors of Memantine Sensitivity

Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Care for Veterans with Alzheimer's or Traumatic Brain Injury (ABC ANSWERS)

Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.

Brain Connections, Self-Care, and Blood Pressure in African Americans with Memory Problems

Purpose:To evaluate a dietary and mindfulness intervention to decrease blood pressure and improve brain function in black and African-American older adults with high blood pressure and early Alzheimer's disease or a related dementia.

Brain Energy for Amyloid Transformation in Alzheimer's Disease (BEAT-AD)

Purpose: To compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.

Brain Energy Metabolism and Sleep in Adults

Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

Brain Safe: Reducing Exposure to Drugs Linked to Alzheimer's

Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

CT1812 for Mild to Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of CT1812 in older adults with mild to moderate Alzheimer's disease.

Calorie Restriction and Brain Function in Mild Cognitive Impairment

Purpose: To test the effects of intermittent calorie restriction in older adults with mild cognitive impairment who are overweight or obese.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

Care Partners Program for Alzheimer's Disease

Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.

Caregiver Outcomes of Alzheimer's Disease Screening

Purpose: To measure the risks and benefits of early screening for Alzheimer's disease in terms of its effects on family caregivers.

Cathodal Transcranial Direct Current Stimulation in MCI

Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

Cleveland Clinic Healthy Brains Registry

Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

Cognitive Training and Neuroplasticity in Mild Cognitive Impairment

Purpose: To evaluate the effects of computer-based cognitive training on everyday cognitive function in older adults with memory loss.

Cognitive Training for Older Caregivers

Purpose: To test whether computer-based brain training activities can promote cognitive, emotional, and physical health in older adult caregivers of a spouse or significant other with dementia.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

Computerized Screening Tool for Cognitive Decline

Purpose: To test a computerized screening tool to detect early cognitive decline in older adults during their doctor's visits.

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

D-CARE: The Dementia Care Study

Purpose: To compare the effectiveness of two evidence-based models of dementia care.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention

Purpose: To test an online group intervention for decreasing caregivers' grief, depression, anxiety, and conflict after their family member transitions to a long-term care facility.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders

Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)

Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

Early-Onset Alzheimer's Disease Genomic Study

Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

Exercise to Improve Cognitive Function in Veterans with MCI

Purpose: To assess the feasibility of a home-based exercise intervention to improve memory in veterans with mild cognitive impairment.

Family Telemental Health Intervention for Veterans with Dementia

Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.

GAIN Trial: COR388 for Alzheimer's Disease

Purpose: To test the efficacy, safety, and tolerability of two doses of the investigational drug COR388 in older adults with mild to moderate Alzheimer's disease.

GRF6019 Infusions for Severe Alzheimer's Disease

Purpose: To evaluate the safety, tolerability, and potential cognitive benefit of the experimental treatment GRF6019 in older adults with severe Alzheimer's disease.

Gamma Induction for Alzheimer's Disease

Purpose: To test the effects of daily brain stimulation on levels of amyloid and tau in people with Alzheimer's disease.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

Grape Seed Extract for Alzheimer's Disease

Purpose: To establish the safety and pharmacokinetics of grape seed extract and to test its cognitive effects in people with Alzheimer's disease.

High-Dose Vitamin D Supplements in Older Adults

Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

Improving Well-Being for Older Adult Family Dementia Caregivers

Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE)

Purpose: To test the effect of a telephone-based intervention on reducing the burdens of dementia-associated symptoms and behaviors.

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.

Intermittent Calorie Restriction, Insulin Resistance, and Brain Function

Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.

Internet-Based Conversational Engagement Clinical Trial (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face web-based conversations could improve cognitive function in older adults who are socially isolated.

Interventions for Circadian Rhythm Disorders in Dementia (Healthy Patterns Sleep Study)

Purpose: To evaluate a program of activities to improve symptoms of disturbed sleep-wake cycles in people with dementia who live at home.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

LY3154207 for Parkinson's Disease Dementia (PRESENCE)

Purpose: To evaluate the safety and efficacy of the investigational drug LY3154207 in people with mild-to-moderate Parkinson's disease dementia.

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Levetiracetam for Alzheimer's Disease-Associated Epileptiform Activity

Purpose: To test the use of levetiracetam, an anticonsulvant, to control seizures in people with Alzheimer's disease.

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Light and Cognitive Therapy for Alzheimer's Disease

Purpose: To test an iPad app that delivers light therapy at 40 Hz, combined with cognitive therapy, to improve cognition in people with Alzheimer's.

Light and Sound Stimulation for Alzheimer's Disease

Purpose: To test the safety and feasibility of noninvasive light and sound stimulation in adults with mild Alzheimer's disease.

Light for Metabolic Syndrome and Alzheimer's

Purpose: To test the effects of a tailored lighting system on sleep, mood, inflammation, and glucose tolerance in older adults with Alzheimer's disease or a related dementia and type 2 diabetes.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

Longitudinal Innate Immunity and Aging Study (LIIA)

Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.

MRI and PET Biomarkers for Cognitive Decline in Older Adults

Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.

MRI-Guided Transcranial Magnetic Stimulation for MCI

Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.

Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults

Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).

Mild Cognitive Impairment in Breast Cancer

Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

Mind-Body Skills and Physical Activity for MCI and Chronic Pain

Purpose: To adapt and examine a mind-body program, called Active Brains, to meet the needs of older adults with chronic pain and mild cognitive impairment.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Mindfulness Training for Caregivers of People with Dementia

Purpose: To test mindfulness-based stress reduction training on caregiver well-being, sleep, and physiological responses to stress.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

Multicultural Healthy Diet to Reduce Cognitive Decline

Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.

Multidimensional Behavioral Intervention for Adults with Cognitive Concerns (BBLite)

Purpose: To promote use of compensation strategies, organization systems, and brain health activities in older adults with concerns about their memory and cognitive function.

Multidimensional Behavioral Intervention in Adults with Memory Concerns

Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.

Music Training to Reduce Cognitive Decline

Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.

NNI-362 in Healthy Older Adults

Purpose: To examine the safety, tolerability, and pharmacokinetics of single and multiple doses of the investigational drug NNI-362 in healthy older adults.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

Near Infrared Light Stimulation for Early to Mid-Stage Dementia

Purpose: To test the effects of a medical device that delivers near infrared light stimulation on people who have early to mid-stage Alzheimer's disease.

Neural Basis of Frontotemporal Degeneration and Related Disorders

Purpose: To study adults with frontotemporal degeneration, multiple systems atrophy, and progressive supranuclear palsy to better understand the causes of these disorders.

Neuroenergetic Adaptations in Alzheimer's Disease (PREPARE)

Purpose: To examine the relationship between brain energetics and risk for Alzheimer's disease.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nicotinamide Riboside for Mild Cognitive Impairment

Purpose: To test the effects of the supplement nicotinamide riboside on memory and brain blood flow in older adults with mild cognitive impairment.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

North American Prodromal Synucleinopathy (NAPS) Consortium

Purpose: To enroll adults with idiopathic rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.

Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD)

Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.

OCTA in Mild Cognitive Impairment and Alzheimer's Disease

Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.

ORY-2001 for Mild to Moderate Alzheimer's Disease (ETHERAL-US)

Purpose: To assess the safety, tolerability, and preliminary efficacy of the experimental drug ORY-2001 in adults with mild to moderate Alzheimer's disease.

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Optimizing Dementia Care for Veterans and Their Caregivers

Purpose: To examine the effectiveness of an established counseling approach and a variation of it for veterans with dementia and their family caregivers who have high levels of stress.

PET Imaging of Neuroinflammation in Neurodegenerative Diseases

Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.

PTI-125 for Mild-to-Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of multiple doses of the investigational drug PTI-125 in people with mild-to-moderate Alzheimer's disease.

Palliative Care for Parkinson's and Related Disorders

Purpose: To compare usual care to palliative care for adults with Parkinson's disease and related disorders.

Performing Arts for Alzheimer's Dementia Caregivers

Purpose: To examine whether a performing arts class will improve the well-being of primary unpaid caregivers of people with Alzheimer's dementia.

Physical Activity and Alzheimer's Disease (PAAD-2)

Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.

Physical Activity with a Body-Worn Sensor

Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen^® in older adults with early-stage Alzheimer’s disease.

Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)

Purpose: To evaluate a mindfulness-based intervention for caregivers of people with dementia.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

Preventing Alzheimer's Disease with Cognitive Training (PACT)

Purpose: To demonstrate the feasibility of a larger trial to test cognitive training for reducing mild cognitive impairment and dementia in older adults with normal cognition.

Preventing Loss of Independence Through Exercise in Mild Cognitive Impairment (PLIE)

Purpose: To test an exercise program in older adults with mild cognitive impairment.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Pupillary Response to Identify Progressive Supranuclear Palsy

Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).

RO7105705 for Moderate Alzheimer's Disease

Purpose: To evaluate the efficacy, safety, pharmacokinetics, and pharmacodynamics of the investigational drug RO7105705 in older adults with moderate Alzheimer's disease.

Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia

Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

Renew NCP-5 for MCI or Mild Alzheimer's

Purpose: To examine the efficacy and safety of the Renew NCP-5 device for the treatment of mild cognitive impairment or mild Alzheimer's disease.

Residential Care Transition for Family Caregivers

Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.

Riluzole for Mild Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

SPIRIT for End-of-Life Decision Making in Mild Alzheimer's

Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild dementia and their surrogates to promote end-of-life care discussions.

Safety and Efficacy of Gantenerumab for Early Alzheimer's

Purpose: To evaluate the safety and efficacy of the investigational drug gantenerumab in people with early Alzheimer's disease.

Salsalate for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and tolerability of twice daily salsalate in adults with mild to moderate Alzheimer's Disease.

Self-Management of Chronic Pain and Negative Emotions

Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.

Sensory Stimulation to Improve Brain Function (Overture Study)

Purpose: To study the effects of an auditory and visual sensory stimulation system on older adults with mild cognitive impairment and Alzheimer's disease.

Sleep Intervention to Enhance Cognitive Status and Reduce Beta-Amyloid (SIESTA)

Purpose: To test the effects of cognitive behavioral training for insomnia (CBT-I) in older adults with symptoms of insomnia.

Social Dancing Movement Intervention for Memory Enhancement (MIME)

Purpose: To test social dancing as a method to prevent or delay cognitive decline in older adults at high risk for Alzheimer's disease and related dementias.

Speech Language Therapy for Primary Progressive Aphasia

Purpose: To evaluate two evidence-based speech language therapy treatments for adults with mild primary progressive aphasia.

Stanford Memory and Aging Study

Purpose: To study memory and aging in healthy older adults.

Stimulation to Undermine Dementia (STUD)

Purpose: To learn about the effects of weak electrical stimulation on brain functioning in people with mild cognitive impairment.

Strategic Training to Optimize Neurocognitive Functions in Older Adults

Purpose: To evaluate the efficacy of a novel cognitive training approach in older adults using simulated games.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

Study to Evaluate Amyloid in Blood and Imaging Related to Dementia (SEABIRD)

Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.

Targeting Verbal Short-Term Memory in Conjunction with tDCS in Neurodegenerative Disorders

Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.

Tau Kinetics in Healthy Aging and Alzheimer's Disease

Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

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