Find Alzheimer’s Disease and Related Clinical Trials
Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.
Clinical Trials Search Results
Results found: 174
Language in Primary Progressive Aphasia
Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.
Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study
Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.
Transcranial Direct Current Stimulation for Primary Progressive Aphasia
Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.
GeneMatch
Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.
Optimizing Postoperative Cognition in the Elderly
Purpose: To compare brain-wave patterns in older patients who have memory and thinking problems after surgery with brain-wave patterns in patients without such problems.
Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)
Purpose: To test methylphenidate (Ritalin®) as a treatment for clinically significant apathy in people with Alzheimer's disease.
Mindfulness-Based Stress Reduction, Health Education, and Exercise
Purpose: To examine the effects on age-related cognitive decline of mindfulness-based stress reduction, aerobic exercise, and their combination, compared with a health discussion group.
Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia
Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.
Pragmatic Trial of Video Education in Nursing Homes (PROVEN)
Purpose: To test the use of a video about advance care planning for nursing home residents.
Dietary Intervention in Cognitive Aging
Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.
Grape Seed Extract for Alzheimer's Disease
Purpose: To establish the safety and pharmacokinetics of grape seed extract and to test its cognitive effects in people with Alzheimer's disease.
ITI-007 for Agitation in Dementia
Purpose: To study the use of ITI-007 to treat agitation in people with dementia, including Alzheimer's disease.
Water-based Activity to Enhance Recall in Veterans (WATER-VET)
Purpose: To evaluate the feasibility of a water-based exercise program with cognitive training to improve memory in veterans with mild cognitive impairment.
4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)
Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.
Communicating Amyloid Neuroimaging (REVEAL-SCAN)
Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.
Nilotinib for Mild to Moderate Alzheimer's Disease
Purpose: To test the safety and efficacy of the drug nilotinib in people with mild to moderate Alzheimer's disease.
ABBV-8E12 for Early Alzheimer's Disease
Purpose: To evaluate ABBV-8E12 in older adults with early Alzheimer's disease.
Insulin Resistance and Accelerated Cognitive Aging
Purpose: To examine cognitive and neural biomarkers in adults who are overweight or obese and younger than 50.
Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's
Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.
Tau PET Imaging in the Dominantly Inherited Alzheimer Network
Purpose: To evaluate a new radioactive compound used in positron emission tomography scans to identify tau tangles.
Dietary Treatments for Cognitive Impairment
Purpose: To study the effect on cognition of a modified Atkins diet in older adults with mild cognitive impairment or early Alzheimer's disease.
Residential Care Transition for Family Caregivers
Purpose: To evaluate a program for decreasing caregiver distress and strain after transitioning a cognitively impaired relative to long-term care.
Mild Cognitive Impairment in Breast Cancer
Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.
BIIB092 for Early Alzheimer's Disease (TANGO)
Purpose:: To evaluate BIIB092 in people with mild cognitive impairment due to Alzheimer's disease or mild Alzheimer's disease.
Antidepressants to Prevent Mild Cognitive Impairment
Purpose: To test two antidepressants in people with subjective cognitive impairment.
Behavioral and Environmental Sensing and Intervention (BESI)
Purpose: To develop and assess a tool enabling caregivers to recognize dementia-related agitation and intervene before it escalates.
Brain Care for Veterans with Alzheimer's or Traumatic Brain Injury (ABC ANSWERS)
Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.
Stem Cell Infusion for Alzheimer's Disease
Purpose: To test the safety and efficacy of a stem-cell infusion to treat people with Alzheimer's disease.
Modified Story Memory Technique (mSMT) to Enhance Memory
Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.
LY3303560 for Early Symptomatic Alzheimer's Disease
Purpose: To evaluate the safety and efficacy of experimental drug LY3303560 in people with early-stage Alzheimer's disease.
Riluzole for Mild Alzheimer's Disease
Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.
Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers
Purpose: To evaluate the effects of surgical anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery.
Insulin Aspart to Fight Forgetfulness
Purpose: To test the effects of fast-acting intranasal insulin on cognition and daily function in people with Alzheimer's disease or mild cognitive impairment.
Cycling Exercise for Treating Alzheimer's Disease
Purpose: To investigate the effects of a cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease.
VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)
Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.
Reliability of the Human Brain Connectome
Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.
Treatment of Psychosis and Agitation in Alzheimer's Disease
Purpose: To test lithium as a treatment for psychosis and agitation in older adults with Alzheimer's disease.
Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment
Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.
Alzheimer's Caregiver Coping: Mental and Physical Health
Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.
Cognitive Training and Practice Effects in MCI
Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.
Levetiracetam for Alzheimer's Disease-Associated Epileptiform Activity
Purpose: To test the use of levetiracetam, an anticonsulvant, to control seizures in people with Alzheimer's disease.
Tele-Savvy Education Program for Dementia Caregivers
Purpose: To test an Internet-based education program for dementia caregivers.
Dietary Influences on Alzheimer's Biomarkers
Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.
ALZT-OP1 for Early-Stage Alzheimer's Disease
Purpose: To test ALZT-OP1 as a treatment for cognitive and functional decline in people with early-stage Alzheimer's disease.
Coaching for Cognition in Alzheimer's and MCI (COCOA)
Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.
Types of Progressive Apraxia of Speech
Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.
Rates of Change in Behavioral Variant Frontotemporal Dementia
Purpose: To study changes in cognitive function in adults with early-stage behavioral variant frontotemporal dementia.
Pupillary Response to Identify Progressive Supranuclear Palsy
Purpose: To investigate pupillary light response as a potential identifier of progressive supranuclear palsy (PSP).
Citicoline for Age-Associated Memory Impairment
Purpose: To determine the effects of citicoline on cognitive performance in healthy adults with age-associated memory impairment.
Natural History Study of Synucleinopathies
Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).
Pimavanserin for Relapse of Dementia-Related Psychosis
Purpose: To evaluate the efficacy of the drug pimavanserin (Nuplazid®) in preventing a relapse of psychotic symptoms in adults with who were previously stabilized after 12 weeks of treatment.
Transcutaneous Vagal Nerve Stimulation for MCI
Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.
Valacyclovir for Mild Alzheimer's Disease
Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.
Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)
Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.
Older Adults with Cognitive Impairment Living Alone
Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.
Role of the Nicotinic System in Cognitive Aging
Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.
Neflamapimod for MCI or Mild Alzheimer's Disease
Purpose: To test the effects of the investigational drug neflamapimod on memory and cognitive function in older adults with mild cognitive impairment or mild Alzheimer's disease.
Transcranial Direct Current Stimulation for Mild Cognitive Impairment
Purpose: To explore transcranial direct current stimulation as a way to improve word finding and memory retrieval in adults with mild cognitive impairment.
Neural Basis of Frontotemporal Degeneration and Related Disorders
Purpose: To study adults with frontotemporal degeneration, multiple systems atrophy, and progressive supranuclear palsy to better understand the causes of these disorders.
Cognitive Training and Transcranial Direct Current Stimulation for HIV-Related Cognitive Dysfunction
Purpose: To test the effects of cognitive training and transcranial direct current stimulation on cognitive function in older adults with HIV-related cognitive dysfunction.
Tau Screening in Early Alzheimer's Disease
Purpose: To prescreen older adults with early Alzheimer’s disease who may be eligible for therapeutic trials requiring tau imaging.
B-Fit Intervention to Improve Brain Health
Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.
Strawberry Powder for Memory and Mobility in Obese Older Adults
Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.
Cortical Stimulation for Mild Cognitive Impairment
Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.
Care Partners Program for Alzheimer's Disease
Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.
Cognitive Rehabilitation and Electrical Stimulation
Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.
S-Equol for Alzheimer's Disease
Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.
Optimizing Dementia Care for Veterans and Their Caregivers
Purpose: To examine the effectiveness of an established counseling approach and a variation of it for veterans with dementia and their family caregivers who have high levels of stress.
Lifestyle Activities for Brain Health
Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.
Transcranial Alternating Current Stimulation for Modulation of Sleep and Cognitive Performance
Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.
Posiphen in Early Alzheimer's Disease (Discover Study)
Purpose: To evaluate Posiphen® in older adults with early-stage Alzheimer’s disease.
Xanamem for Mild Alzheimer's Disease
Purpose: To assess the experimental drug Xanamem® in older adults with mild Alzheimer's disease.
Movement and Music for Older Adults with Dementia
Purpose: To learn about the possible benefits of movement and music in older adults with dementia.
Palliative Care for Parkinson's and Related Disorders
Purpose: To compare usual care to palliative care for adults with Parkinson's disease and related disorders.
Mediterranean Diet, Weight Loss, and Cognition in Obese Older Adults
Purpose: To determine if following a Mediterranean diet resulting in weight loss improves cognition in obese older adults.
Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.
Nicotinamide as an Early Alzheimer's Treatment (NEAT)
Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.
AXS-05 for Agitation in Alzheimer's
Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.
Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's
Purpose:To test whether Horizant®, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.
Prazosin in Veterans with Mild Traumatic Brain Injury
Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.
RO7105705 for Prodromal to Mild Alzheimer's Disease
Purpose: To evaluate the efficacy and safety of the experimental drug RO7105705 in people with prodromal to mild Alzheimer's disease.
Cognitive Training and Vortioxetine for Age-Related Cognitive Decline
Purpose: To examine the potential benefits of a combination of at-home cognitive training and Trintellix® on cognition in older adults with age-related cognitive decline.
Family Telemental Health Intervention for Veterans with Dementia
Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.
Salsalate for Mild to Moderate Alzheimer's Disease
Purpose: To test the safety and tolerability of twice daily salsalate in adults with mild to moderate Alzheimer's Disease.
Tau PET Imaging Using 18F-AV-1451
Purpose: To evaluate a new radioactive compound used in positron emission tomography scans in identifying tau tangles.
Piromelatine for Mild Alzheimer's Disease (ReCOGNITION)
Purpose: To test the safety and efficacy of the experimental drug piromelatine in people with mild Alzheimer's dementia.
TRx0237 for Mild Alzheimer's
Purpose: To determine the safety and efficacy of the investigational treatment TRx0237 in older adults with mild Alzheimer's disease.
Effects of Brain Beta-Amyloid on Postoperative Cognition
Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.
Music Training to Reduce Cognitive Decline
Purpose: To test whether music training can stave off cognitive decline in older adults with and without mild cognitive impairment.
Glutathione for Mild Cognitive Impairment
Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.
Biomarkers in Lewy Body Dementia
Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.
CPAP Treatment of Obstructive Sleep Apnea for MCI
Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.
Yoga and Meditation for Reducing Alzheimer's Risk in Women with MCI
Purpose: To test the effects of kundalini yoga and kirtan kriya yogic meditation, in comparison to memory training, in improving cognitive function, health, and mood in older adult women with mild cognitive impairment.
Aerobic Exercise and Cognitive Training for MCI (ACT Trial)
Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.
SPIRIT for End-of-Life Decision Making in Mild Alzheimer's
Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild Alzheimer's disease and their surrogates to promote end-of-life care discussions.
Cathodal Transcranial Direct Current Stimulation in MCI
Purpose: To evaluate the application of cathodal transcranial direct current stimulation using an investigational device to treat mild cognitive impairment in older adults.
APOE, Metabolism, and Cognitive Function
Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.
Home Visits for Progressive Supranuclear Palsy and Related Disorders (CarePSP)
Purpose: To test a home visit program designed to assess the needs of people with progressive supranuclear palsy (PSP) or related disorders and to connect them with services.
Program for African American Cognition and Exercise (PAACE)
Purpose: To develop and evaluate a program to increase physical activity and improve cognitive function in African-American older adults who are sedentary.
Brexpiprazole for Agitation in Alzheimer's
Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti®) in older adults with agitation associated with Alzheimer's disease.
Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)
Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.
Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)
Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.
Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)
Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.
Multidimensional Behavioral Intervention in Adults with Memory Concerns
Purpose: To promote use of compensation strategies and organization systems and increased engagement with brain health activities in older adults with memory concerns.
CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's
Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.
Sensory Stimulation to Improve Brain Function (Overture Study)
Purpose: To study the effects of an auditory and visual sensory stimulation system on older adults with mild cognitive impairment and Alzheimer's disease.
Internet-Based Conversational Engagement for Socially Isolated Older Adults (I-CONECT)
Purpose: To examine whether increasing social interaction through face-to-face Web-based conversations could improve cognitive function in older adults who are socially isolated.
Self-Management of Chronic Pain and Negative Emotions
Purpose: To examine the effects of an intervention to reduce negative emotions and pain in older adults who are cognitively normal or have mild cognitive impairment.
Methylation Diet and Lifestyle Changes in Older Adult Men
Purpose: To evaluate a diet and lifestyle intervention on methylation-related biomarkers in healthy older adult men.
Escitalopram for Agitation in Alzheimer's Disease
Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro®) to treat agitation in Alzheimer's disease.
Brain Aging in Vietnam War Veterans (DOD-ADNI)
Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.
Curcumin and Yoga Therapy for Mild Cognitive Impairment
Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.
MindCrowd
Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.
Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)
Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.
Stanford Memory and Aging Study
Purpose: To study memory and aging in healthy older adults.
Telmisartan to Prevent Alzheimer's in African Americans
Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.
BDPP Treatment for Mild Cognitive Impairment and Prediabetes
Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.
SUVN-502 with Donepezil and Memantine for Moderate Alzheimer's Disease
Purpose: To test the experimental drug SUVN-502 as a treatment for moderate Alzheimer's disease in people taking donepezil and memantine.
Auditory Stimulation of Slow-Wave Sleep and Memory in Older Adults
Purpose: To evaluate the ability of sounds played during slow-wave sleep to enhance sleep and memory in older adults.
LY3002813 for Mild Cognitive Impairment or Alzheimer's Disease
Purpose: To evaluate the effect of LY3002813 in people with mild cognitive impairment or Alzheimer's disease.
Auditory Training to Improve Hearing
Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.
Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving
Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.
Physical Activity with a Body-Worn Sensor
Purpose: To assess the effect on cognition of increasing physical activity using a body-worn sensor in older adults.
Exercise and Vascular Risk Reduction for Alzheimer's
Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.
VU319 in Healthy Adult Volunteers
Purpose: To study the pharmacokinetics and effects of VU319 in healthy adults.
NDX-1017 in Healthy Volunteers and People with Mild Alzheimer's
Purpose: To evaluate the safety, tolerability, and action of the experimental drug NDX-1017 in healthy volunteers and adults with mild Alzheimer's disease.
Cognitive Training to Improve Brain Function
Purpose: To examine changes in brain function as a result of cognitive training in older adults with and without mild cognitive impairment.
Dietary Ketosis for Memory Loss and MCI
Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.
Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)
Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.
Tau PET Imaging and Cognition
Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.
A-LIST: Patients and Families Transforming Alzheimer's Research
Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.
LY3002813 and LY3202626 for Early Alzheimer's Disease (TRAILBLAZER-ALZ)
Purpose: To evaluate the safety, tolerability, and efficacy of the investigational drugs LY3002813 and LY3202626 in older adults with early symptomatic Alzheimer's disease.
Dronabinol to Treat Agitation in Alzheimer's Disease
Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.
Cholinesterase Inhibitor Discontinuation
Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.
CNP520 to Slow or Prevent Alzheimer's (Generation 2)
Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.
Cognitive and Aerobic Resilience for the Brain (CARB)
Purpose: To test the impact of cognitive and/or exercise training on cognition in older adults with mild cognitive impairment.
Cognitive Behavioral Therapy for African Americans with MCI
Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.
Cognitive Detection of Preclinical Alzheimer's: Validation Using Biomarkers
Purpose: To validate several novel cognitive tasks and correlate them with Alzheimer's disease biomarkers in people who are cogntitively normal or have mild cognitive impairment.
Alzheimer's Disease Genetics Study
Purpose: To identify the genes that cause late-onset Alzheimer's disease.
Crenezumab for Early Alzheimer's Disease (CREAD 2)
Purpose: To evaluate the efficacy and safety of crenezumab in adults with prodromal to mild Alzheimer's disease.
Dominantly Inherited Alzheimer Network (DIAN)
Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Effects of Donepezil Measured by Functional MRI
Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).
CADASIL Disease Discovery
Purpose: To learn more about cerebral autosomal dominant arteriopathy with subcortical infarct (CADASIL).
Exercise in Adults with Mild Memory Problems (EXERT)
Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.
Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)
Purpose: To learn more about biomarkers and their relationship to aging.
Genetic Characterization of Movement Disorders and Dementias
Purpose: To learn more about the genetic causes of movement disorders and dementias.
Independent Walking in Older Adults for Brain Health
Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.
CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)
Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.
Memory Improvement Through Nicotine Dosing (MIND)
Purpose: To test the effects of a nicotine skin pitch on memory performance in older adults with mild cognitive impairment (MCI).
Alzheimer Prevention Trials (APT) Webstudy
Purpose:To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.
Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)
Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.
Candesartan's Effects on Alzheimer's Disease and Related Biomarkers
Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.
Brain Health Registry
Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.
AVP-786 for Agitation in Dementia of the Alzheimer's Type
Purpose: To test the experimental drug AVP-786 as a treatment for agitation in people with Alzheimer's dementia.
E2609 for MCI and Early Alzheimer's (Mission AD2)
Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.
Bisnorcymserine in Healthy Adult Volunteers
Purpose: To test the safety and action of the drug bisnorcymserine in healthy older volunteers.
Cognitive Function in Adults With and Without HIV
Purpose: To better understand how the HIV virus affects the brain and cognitive aging.
COR388 in Healthy Volunteers and People with Alzheimer's
Purpose: To assess the safety and tolerability of the investigational drug COR388 in healthy older adults and those with Alzheimer's disease.
Down Syndrome Memantine Follow-up Study
Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.
Intermittent Calorie Restriction, Insulin Resistance, and Brain Function
Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.
Aerobic Exercise and Cognitive Training in Older Adults
Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.
Cognitive Training for Fall Prevention
Purpose: To test whether cognitive training can help decrease falls in older adults who are at risk for falls.
E2609 for MCI and Early Alzheimer's (Mission AD1)
Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.
ABBV-8E12 for Progressive Supranuclear Palsy
Purpose: To assess the safety, dosing, and action of ABBV-8E12, an anti-tau antibody, in people with progressive supranuclear palsy.
Benfotiamine in Alzheimer's Disease
Purpose: To determine whether treatment with benfotiamine, a dietary supplement, minimizes cognitive decline in older adults with amnestic mild cognitive impairment or mild Alzheimer's disease.
ACI-24 Vaccine in Adults with Down Syndrome
Purpose: To test the ACI-24 vaccine in adults with Down syndrome.
Bryostatin for Moderate to Severe Alzheimer's Disease
Purpose: To test bryostatin as a treatment for moderate to severe Alzheimer's disease in older adults not receiving memantine (Namenda® or Namzaric®).
Cognitive Rehabilitation for Older Veterans with MCI
Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.
Alzheimer's Disease, Caregiving, and Social Networks
Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.
Alzheimer's Prevention Registry
Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.
Alzheimer's Prevention Through Exercise
Purpose: To learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.
AstroStem to Treat Alzheimer's Disease
Purpose: To test the safety and efficacy of an investigational stem cell drug, AstroStem, for treating the symptoms of Alzheimer's disease in older adults.
BIIB076 for Early Alzheimer's Disease
Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.
Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)
Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.