Find Alzheimer’s Disease and Related Clinical Trials

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

The Goal Of This Observational Study Is To Identify Reliable Methods For Tracking The Progression Of Corticobasal Degeneration (CBD), Progressive Supranuclear Palsy (PSP), And Oligosymptomatic/variant Progressive Supranuclear Palsy (o/vPSP) Over Time.

ACI-24 Vaccine in Adults with Down Syndrome

Purpose: To test the ACI-24 vaccine in adults with Down syndrome.

This Phase I Study Will Test The ACI-24 Vaccine In Adults With Down Syndrome To Assess Whether The Vaccine Is Safe, Tolerable, And Able To Stimulate An Immune Response.

AD-35 for Mild to Moderate Alzheimer's

Purpose: To evaluate the safety, tolerability, efficacy, and behavior of AD-35 in older adults with mild to moderate Alzheimer's disease.

This Phase II Trial Will Test The Safety, Tolerability, And Effects Of AD-35 On Cognitive Function In Older Adults With Mild To Moderate Alzheimer's Disease.

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

This Phase III Clinical Trial Will Evaluate Whether AGB101 Slows Cognitive And Functional Impairment In People With Prodromal Alzheimer's Disease (mild Cognitive Impairment Due To Alzheimer's)

A-LIST: Patients and Families Transforming Alzheimer's Research

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

The A-LIST Is An Online Community Of People With Or At Risk For Alzheimers Disease, Other Dementias, And Mild Cognitive Impairment (MCI), Along With Current And Former Care Partners, Designed To Increase Patient And Caregiver Engagement In Research.

ALZT-OP1 for Early-Stage Alzheimer's Disease

Purpose: To test ALZT-OP1 as a treatment for cognitive and functional decline in people with early-stage Alzheimer's disease.

This Phase III Clinical Trial Will Test The Experimental Drug ALZT-OP1 As A Treatment For People With Early-stage Alzheimer's Disease. Researchers Will Evaluate The Drug's Safety And Tolerability And Determine If It Can Slow Down, Stop, Or Reverse Cognitive And Functional Decline.

AMX0035 to Treat Alzheimer's Disease

Purpose: To assess the safety, tolerability, and effects of the investigational drug AMX0035 for people with late mild cognitive impairment or early dementia due to Alzheimer's disease.

This Phase II Study Will Assess The Safety, Tolerability, And Effects Of The Investigational Drug AMX0035 For People With Late Mild Cognitive Impairment Or Early Dementia Due To Alzheimer's Disease.

APOE, Metabolism, and Cognitive Function

Purpose:To better understand the relationship between APOE genotype and metabolism by testing metabolic rate at rest and during a cognitive challenge in healthy adults.

This Study Aims To Better Understand The Relationship Between Variations Of The APOE Gene And Metabolism By Testing Metabolic Rate At Rest And During A Cognitive Challenge In Healthy Adults. Results May Help Investigators Identify New Targets For The Prevention And Treatment Of Cognitive Decline And Dementia.

AVP-786 for the Treatment of Agitation in Alzheimer's

Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.

This Phase III Clinical Trial Will Evaluate The Efficacy, Safety, And Tolerability Of The Drug AVP-786 As A Treatment For Agitation In People With Alzheimer's Disease.

AXS-05 for Agitation in Alzheimer's

Purpose: To assess the efficacy and safety of investigational drug AXS-05 in treating agitation in older adults with Alzheimer's.

This Phase II/III Randomized Trial Will Assess The Efficacy And Safety Of AXS-05, An Investigational Drug Combining FDA-approved Bupropion And Dextromethorphan, To Treat agitation In Older Adults With Alzheimer's Disease.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

The Goal Of This Study Is To Build A Clinical Research Consortium To Test New Treatments For People With Frontotemporal Lobar Degeneration (FTLD), Including Frontotemporal Dementia (FTD), Primary Progressive Aphasia (PPA), Corticobasal Degeneration (CBS), And Progressive Supranuclear Palsy (PSP).

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

Combining Aerobic Exercise And Cognitive Training, This Study Will Compare The Effects Of Cycling And Cognitive Training Alone And Together in Older Adults With Mild Cognitive Impairment (MCI).

Aerobic Exercise and Cognitive Training in Older Adults

Purpose: To examine the impact of a combined cognitive training and aerobic exercise intervention in sedentary older adults.

This Study Will Examine The Impact Of Cognitive Training And Aerobic Exercise In Sedentary Older Adults, Specifically Older Adults At Risk For Mobility Disability. Participants Will Be Randomly Assigned To Either A Group That Does Cognitive Training Alone Or A Group That Does Combined Cognitive Training And Aerobic Exercise.

Alzheimer Prevention Trials (APT) Webstudy

Purpose:To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

The Alzheimer Prevention Trials (APT) Webstudy Is An Online Registry Designed To Accelerate Enrollment For Alzheimer's Disease Clinical Trials By Identifying And Tracking Individuals Who May Be At Higher Risk For Developing Alzheimer's dementia.

Alzheimer's, Autism, and Cognitive Impairment Stem Cell Treatment Study (ACIST)

Purpose: To evaluate the effects of stem cell therapy and infrared light treatment on cognitive function in Alzheimer's disease and related dementias and on behavior in adult autism spectrum disorder.

This study Will Evaluate The Use Of Autologous Bone Marrow-derived Stem Cells And Near Infrared Light To Improve Cognitive Impairment In Alzheimer's And Related Dementias And To Improve Behavior And Socialization Issues In Adult Autism Spectrum Disorder.

Alzheimer's Caregiver Coping: Mental and Physical Health

Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

This Study Will Compare Two Intervention Strategies For Reducing Emotional And Cardiovascular Disease Risk In Alzheimer's Caregivers: Behavioral Activation Therapy And Support And Information.

Alzheimer's Disease, Caregiving, and Social Networks

Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.

Most Studies On Alzheimer's Disease (AD) Caregiving Focus On The Primary Caregiver. More Research Is Needed On How The Disease Affects The Broader Family Network. In This Study, Researchers Will Examine Caregiving In A Family Social Network To consider How All Family Caregivers Adapt To Their Roles. At Least One Caregiver And One Family Member Who Provides Care Indirectly (e.g., Supports The Caregiver) Will Be Surveyed. Researchers Will Also Compare levels Of Perceived Family Health History Risk.

Alzheimer's Disease Genetics Study

Purpose: To identify the genes that cause late-onset Alzheimer's disease.

The Purpose Of The Alzheimer's Disease Genetics Study Is To Identify And Analyze The Genes That Cause Late-onset Alzheimer's Disease. Researchers Are Collecting Genetic Material From Families In The United States In Which Two Or More Members Have Late-onset Alzheimer's.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

The Purpose Of This Observational Study Is To Determine The Relationships Among Clinical, Cognitive, Imaging, Genetic, And Biomarker Characteristics Of The Entire Spectrum Of Alzheimer's Disease As It Progresses From A Preclinical Stage To Very Mild Symptoms To Mild Cognitive Impairment (MCI) To Dementia. Participants Sought Include Those With Normal Cognition, MCI, Or Mild Alzheimer's Dementia (currently Recruiting Non-Caucasian Participants Only For The Normal Cognition Group).

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

The Alzheimer's Prevention Registry Is A National Registry Of Individuals Age 18 And Older Who Are Interested In Learning About And Possibly Participating In Alzheimer's Prevention Clinical Studies And Trials. The Registry Will Collect Contact And Demographic Information, Provide Information About The Latest News And Advances In Alzheimer's Prevention Research, And Inform Enrollees About Research Studies In Their Community.

Antidepressants to Prevent Mild Cognitive Impairment

Purpose: To test two antidepressants in people with subjective cognitive impairment.

This Study Will Test Two Antidepressants, Escitalopram (Lexapro) And Venlafaxine (Effexor XR), To Assess Their Effects On Memory And Cognition In People With Subjective Cognitive Impairment. Participants Are Cognitively Normal But Are Concerned About Their memory.

Apathy in Dementia Methylphenidate Trial 2 (ADMET 2)

Purpose: To test methylphenidate (Ritalin^®) as a treatment for clinically significant apathy in people with Alzheimer's disease.

ADMET 2 Will Test Methylphenidate (Ritalin^®), A Drug Approved To Treat Symptoms Of Attention Deficit Hyperactivity Disorder And Narcolepsy, As Treatment For Clinically Significant Apathy In People With Alzheimer's Disease.

AstroStem to Treat Alzheimer's Disease

Purpose: To test the safety and efficacy of an investigational stem cell drug, AstroStem, for treating the symptoms of Alzheimer's disease in older adults.

This Phase I/II Study Will Test The Safety And Efficacy Of An Investigational Stem Cell Drug, AstroStem, For Treating The Symptoms Of Alzheimer's Disease.

Auditory Stimulation of Slow-Wave Sleep and Memory in Older Adults

Purpose: To evaluate the ability of sounds played during slow-wave sleep to enhance sleep and memory in older adults.

This Study Will Evaluate The Ability Of Sounds Played During Slow-wave Sleep To Enhance Sleep And Memory In Cognitively Healthy Older Adults And In Those With Amnestic Mild Cognitive Impairment (aMCI).

Auditory Training to Improve Hearing

Purpose: To test the effects of different kinds of auditory training on hearing function in healthy adults.

This Study Will Test The Effects Of Different Kinds Of Auditory Training On Hearing Function In Healthy Adults. Hearing Loss Has Been Associated With Cognitive Decline And Decreased Quality Of Life, And Researchers Are Exploring Whether Such Auditory Training Could Compensate For And/or Reverse Hearing Deficits In Older Adults.

BAN2401 for People with Early Alzheimer's Disease

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease

This Phase III Trial Will Test The Effectiveness Of The Experimental Drug BAN2401 As A Possible Treatment For Alzheimer's Disease. 

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

People With Mild Cognitive Impairment (MCI) Are At Risk Of Developing Dementia. Those With Deficits In Short-term Recall (amnestic MCI) Are At Significant Risk Of Developing Alzheimer's Disease. In This Study, People With MCI And Prediabetes Will Consume A Nutraceutical Drink, Called A Bioactive Dietary Polyphenol Preparation (BDPP), To See If It Can Improve Cognition And Delay Or Prevent Dementia.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

The Purpose Of This Study Is To Evaluate A Brain Fitness Intervention For improving Cognitive Health In Middle-aged And Older Adults.

BHV-4157 for Alzheimer's Disease (T2 Protect AD)

Purpose: To test the investigational drug BHV-4157 as a possible treatment and prevention for the symptoms of Alzheimer's disease.

BHV-4157, Also Known As Troriluzole, Is An Investigational Drug That Researchers Are Testing To Determine If It Can Protect Against, Slow Down, And Potentially Improve Memory And Thinking Problems In Adults With Mild To Moderate Alzheimer's Disease.

BIIB076 for Early Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of BIIB076 in cognitively normal older adults and older adults with Alzheimer's disease.

This Study Will Evaluate The Safety And Tolerability Of BIIB076 In Cognitively Normal Older Adults And Older Adults With Alzheimer's Disease.

BIIB092 for Early Alzheimer's Disease (TANGO)

Purpose:: To evaluate BIIB092 in people with mild cognitive impairment due to Alzheimer's disease or mild Alzheimer's disease.

The Study Will Evaluate BIIB092, A Monoclonal Antibody, In People With Mild Cognitive Impairment (MCI) Due To Alzheimer's Disease Or Mild Alzheimer's Disease.

BIIB092 in Primary Tauopathies

Purpose: To test the safety, tolerability, and effects of the investigational drug BIIB092 in people with one of four different tauopathy syndromes.

This Phase 1b Randomized Clinical Trial Will Test The Safety, Tolerability, And Effects Of The Investigational Drug BIIB092, A Monoclonal Antibody, When It Is Intravenously Infused In People That Have One Of Four Different Tauopathy Syndromes.

Behavioral and Environmental Sensing and Intervention (BESI)

Purpose: To develop and assess a tool enabling caregivers to recognize dementia-related agitation and intervene before it escalates.

The Goal Of This Study Is To Develop and Evaluate A Tool To Help Caregivers Recognize Dementia-related Agitation And Intervene Before The Distress Escalates. The Tool Is Designed To Help Reduce Caregiver Burden And Extend Aging-in-place For People With Dementia.

Biomarkers in Lewy Body Dementia

Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.

The Goal Of This Longitudinal Study Is To Discover Better Biomarkersmeasures Of What's Happening Inside The Living Bodyfor Diagnosis And Treatment Of Lewy Body Dementia.

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Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

This Phase II Study Will Test Whether Lowering Blood Pressure Using Antihypertensive Drugs Alters Brain Pulsatility, A Measure Of Blood Flow, And Reduces Amyloid-beta Accumulation In The Brains Of Older Adults.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Traumatic Brain Injury (TBI) And Post Traumatic Stress Disorder (PTSD) Are Common Combat-related Problems And May Be Associated With A Greater Risk Of Alzheimer's Disease. This Study Will Examine The Possible Connections Between TBI And PTSD, And The Signs And Symptoms Of Alzheimer's In Vietnam War Veterans As They Age.

Brain Care for Veterans with Alzheimer's or Traumatic Brain Injury (ABC ANSWERS)

Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.

Most people With Alzheimer's Disease Or Traumatic Brain Injury receive Significant Amounts Of Care From family Members Or Friends. This Study Will Test An Intervention That Is Designed To Improve The Informal Care Of Veterans With Alzheimer's Disease Or Traumatic Brain Injury And To Reduce The Burden On Their caregivers.

Brain Connections, Self-Care, and Blood Pressure in African Americans with Memory Problems

Purpose:To evaluate a dietary and mindfulness intervention to decrease blood pressure and improve brain function in black and African-American older adults with high blood pressure and early Alzheimer's disease or a related dementia.

This Study Is Designed To Help Adapt A Previously Tested Intervention Involving The DASH (Dietary Approaches To Stop Hypertension) Diet And Mindfulness Techniques For Black And African American Older Adults With High Blood Pressure And Early Alzheimer's Disease Or A Related Dementia.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

The Purpose Of The Online Brain Health Registry Is To Recruit And Observe People Who Are Interested In Promoting Healthy Brain Function Through The Prevention Of Brain Diseases, Disorders, And Injuries In Adults. Participation Involves Answering Questions About Your Health, Lifestyle, And Medical History And Taking Online Brain Tests. Researchers Hope To Build A Large Pool Of Potential Participants For Clinical Trials, Reducing The Time And Cost Of Research.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

This Phase III Study Compares The Efficacy Of Two Different Doses Of Brexpiprazole (Rexulti) With Placebo In Older Adults Who Are Experiencing Agitation Associated With Alzheimer's Disease.

CAD106 and CNP520 to Prevent or Delay Symptoms of Alzheimer's Disease (Generation)

Purpose: To test whether two investigational drugs, CAD106 and CNP520, can prevent or delay Alzheimer's symptoms in people at high risk.

This Clinical Trial Will Test Whether Two Investigational Drugs, CAD106 And CNP520, Administered Separately, Can Prevent Or Delay Alzheimer's Disease Symptoms In People At High Risk Of Developing Dementia Based On Their Age And Genetic Status.

CNP520 to Slow or Prevent Alzheimer's (Generation 2)

Purpose: To determine the safety and effects of CNP520 in cognitively normal older adults who are at risk for Alzheimer's disease.

The Generation 2 Study Will Test The Safety And Effects Of The Investigational Drug CNP520 in Cognitively Normal Older Adults Who Are At risk Of Developing Dementia Based On Their Age, Genetic Status, And Brain Amyloid Levels.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

The Purpose Of This 1-year Study Is To Determine Whether Treatment Of Obstructive Sleep Apnea With A Continuous Positive Airway Pressure (CPAP) Machine Can Delay The Progression Of Cognitive Impairment In Older Adults With Mild Cognitive Impairment (MCI).

CT1812 and Brain Synaptic Density in Mild to Moderate Alzheimer's

Purpose: To test the effect of the investigational drug CT1812 on brain synaptic density in adults with mild to moderate Alzheimer's disease.

This Phase I/II Study Will Test The Effects Of The Investigational Drug CT1812 On Brain Synaptic Density In Adults With Mild To Moderate Alzheimer's Disease.

CT1812 for Mild to Moderate Alzheimer's Disease

Purpose: To study the safety and efficacy of CT1812 in older adults with mild to moderate Alzheimer's disease.

This Phase II Trial Will Study The Safety And Efficacy Of Two Different Doses Of The Investigational Drug CT1812 In Adults With Mild To Moderate Alzheimer's Disease.

Candesartan's Effects on Alzheimer's Disease and Related Biomarkers

Purpose: To investigate the effect of candesartan, a blood pressure medication, on cognitive function in people with mild cognitive impairment.

This Phase II Study Will Investigate The Effect Of Candesartan, A Medication Used To Treat High Blood Pressure, On Cognitive Function In People With Mild Cognitive Impairment (MCI), A Condition Of Higher-than-normal Memory And Thinking Difficulties For One's Age.

Care Partners Program for Alzheimer's Disease

Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.

In This Study, Researchers Will Develop And Test A Tailored, Tablet-based Program For Family Caregivers Of People With Alzheimer's Disease. The Program Will Combine An Evidenced-based Caregiver Intervention And Cognitive Training For The Person With Alzheimer's.

Caregiver Outcomes of Alzheimer's Disease Screening

Purpose: To measure the risks and benefits of early screening for Alzheimer's disease in terms of its effects on family caregivers.

This Randomized Controlled Trial Will Measure The Risks And Benefits Of Early Screening For Alzheimer's Disease In Terms Of Its Effects On Family Caregivers. Early Diagnosis Through Screening May Enhance The Family Member's Transition To Caregiving And Reduce Caregiver Burden By Providing An Opportunity For The Family Member To Learn About The Syndrome, Receive Interventions, And Prepare For The New Caregiving Role.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

This Clinical Trial Will Use Positron Emission Tomography (PET) Scanning To Measure The Clearance Of Waste From The Brain Via Cerebrospinal Fluid. The Objective Is To Determine The Role Of Impaired Clearance In The Buildup Of The Amyloid Protein In The Aging Brain And Risk For Alzheimer's Disease. A Harmful Form Of Amyloid Is Seen In The Brains Of People With Alzheimer's.

Cholinesterase Inhibitor Discontinuation

Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.

This Study Aims To Determine If Stopping Certain Medications For Alzheimer's Disease Will Cause Worsened Cognition, Functioning, Or Behavior In Veterans With Advanced Dementia Who Have Been Taking A CI (donepezil Or Galantamine) For At Least One Year.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

The COCOA Study Will Test The Effects Of 2 Years Of Coaching In Adults With Mild Cognitive Impairment (MCI) And Alzheimer's Disease. Researchers Believe That Providing Coaching, In Addition To Routine Care, May Improve Memory, Cognitive Function, And Quality Of Life.

Cognitive and Aerobic Resilience for the Brain (CARB)

Purpose: To test the impact of cognitive and/or exercise training on cognition in older adults with mild cognitive impairment.

This Trial Will Test The Impact Of Cognitive And/or Exercise Training On Cognition In Older Adults With Mild Cognitive Impairment (MCI).

Cognitive Behavioral Therapy for African Americans with MCI

Purpose: To test the effects of a cognitive-behavioral therapy program on cognitive performance and stress levels in African-American adults with mild cognitive impairment.

Cognitive Behavioral Therapy (CBT) Is A Psychological Approach That Addresses The Interaction Between People's Thoughts, Feelings, And Behavior. This Study Will Test The Effects Of CBT compared With Usual Care In Reducing Stress Levels And Improving Cognitive Performance In African-American Adults With Mild Cognitive Impairment (MCI).

Cognitive Rehabilitation and Electrical Stimulation

Purpose: To evaluate the effects of cognitive rehabilitation and transcranial electrical stimulation in adults who are cognitively normal or experiencing cognitive dysfunction.

This Study Will Evaluate The Effects Of Cognitive Rehabilitation And Transcranial Electrical Stimulation (TES) On Cognitive Abilities In Adults Who Are Cognitively Normal Or Experiencing Cognitive Dysfunction.

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

This Study Will Evaluate The Effectiveness Of A Cognitive Rehabilitation Group Treatment For Veterans With Mild Cognitive Impairment (MCI).

Cognitive Training and Practice Effects in MCI

Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.

This Study Will Test The Effectiveness Of A Computerized Cognitive Training Program To Improve Thinking And Memory In People With Mild Cognitive Impairment (MCI).

Cognitive Training and Transcranial Direct Current Stimulation for HIV-Related Cognitive Dysfunction

Purpose: To test the effects of cognitive training and transcranial direct current stimulation on cognitive function in older adults with HIV-related cognitive dysfunction.

This Study Will Test The Effects Of Cognitive Training And Transcranial Direct Current Stimulation (tDCS) On Cognitive Function In Older Adults With Human Immunodeficiency Virus (HIV)-related Cognitive Dysfunction.

Communicating Amyloid Neuroimaging (REVEAL-SCAN)

Purpose: To examine the impact on older adults of learning the results of amyloid brain imaging.

This Study Examines The Impact On Older Adults Of Learning The Results Of Amyloid Brain Imaging, Which Can Indicate Risk For Alzheimer's Disease. 

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

This Study Will Test The Efficacy Of Repetitive Transcranial Magnetic Stimulation (rTMS) As A Treatment For Older Adults With Mild Cognitive Impairment (MCI).

Cross-Cultural Comparison of Alzheimer's Symptoms and Caregiving

Purpose: To compare Alzheimer's disease caregiving in the United States and Mexico.

This Interview-based Study Compares Alzheimer's Disease caregiving In The United States And Mexico. The Goal Is To Identify Cross-cultural Differences In Order To Identify Strategies That May reduce The Burden Of The Disease On Family Caregivers. 

Curcumin and Yoga Therapy for Mild Cognitive Impairment

Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

This Study Will Determine The Impact Of Two Interventions In People With Early Memory Problems. First, It Will Test the Clinical Benefits Of Curcumin, A Compound Isolated From turmeric Root, A component Of Indian Curry Spices That Has Been Found To Inhibit Several Potential Pathways In Alzheimer's Disease. Second, It Will determine The Effect Of adding A Yoga-based physical Exercise Program.

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

This Study Will examine The Feasibility Of Biochemical Assays, Genetic Testing, And Cognitive And Lifestyle Assessments In The Diagnosis Of Alzheimer's Disease, Mild Cognitive Impairment, And Other Neurodegenerative Diseases. The Study Also Aims To Assess Changes In Biological, Lifestyle, And Cognitive Assessments Collected From Individuals Over Time.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

This Study Will Test The Effects, Safety, And Tolerability Of Dapagliflozin, Also Known As Farxiga, In Adults With Mild To Moderate Alzheimer's Disease. Researchers Are Investigating Whether This Drug Can Slow Alzheimer's Disease.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

The Goal Of This Project Is To Identify Whether Carrying The APOE 4 Allele, the Strongest Genetic Risk Factor For Developing Alzheimer's Disease, Is Associated With Reduced Delivery Of DHA, An Omega-3 Fatty Acid, To The Brain in Cognitively Healthy Older Individuals. This Information Will Help Identify The Target Population That Could Benefit From DHA Supplementation To Prevent Cognitive Decline.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

This Study Will Examine The Effect Of Different Types Of Meals On Cognitive Function And Alzheimer's Biomarkers In Healthy Older Adults With And Without The APOE E4 Genotype. 

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

This Study Will Test Two Dietary Interventions In Overweight, Middle-aged Adults With Subjective Memory Complaints: A Powdered Berry Supplement And A Carbohydrate-restricted Diet Designed To Induce Ketone Metabolism.

Dietary Ketosis for Memory Loss and MCI

Purpose: To explore the effect of dietary ketosis on adults with early-stage memory loss and metabolic syndrome.

The Study Will Explore The Effect Of Dietary Ketosis (a High-fat, Low-carbohydrate Diet Also Known As The Ketogenic Diet) On Adults With Early-stage Memory Loss And Metabolic Syndrome.

Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders

Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.

In This Study investigators Will Test The Effects Of A Compound Derived From Cocoa, Known As A Flavanol, On Brain Structures, Cognition, And Inflammation In Older Adults Without Memory Problems. 

Dietary Treatments for Cognitive Impairment

Purpose: To study the effect on cognition of a modified Atkins diet in older adults with mild cognitive impairment or early Alzheimer's disease.

This Clinical Trial Will Test The Feasibility Of A Modified Atkins Diet (MAD) And Whether The MAD Results In Better Cognitive Test Scores Than A Placebo Diet In Older Adults With Mild Cognitive Impairment (MCI) Or Early Alzheimer's Disease Living In The Community.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

This Study Will Use A Variety Of Assessments And Clinical And Biological Measures To Characterize Adults With Three Different Disorders: Alzheimer's Disease, Lewy Body Dementia, And Parkinson's Disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

The Purpose Of This Study Is To Identify Potential Biomarkers That May Predict The Development Of Alzheimer's Disease In People Who Carry An Alzheimer's Mutation.

Down Syndrome Memantine Follow-up Study

Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

This Study Will Determine If The Alzheimer's Disease Drug Memantine Hydrochloride Can Improve Learning And Memory In Adolescents And Young Adults With Down Syndrome.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

This Trial Will Test The Safety And Efficacy Of Dronabinol (Marinol), A Medication Approved To Treat Chemotherapy-related Nausea And Vomiting And AIDS-related Lack Of Appetite, In Treating Agitation In Older Adults With Alzheimer's.

E2609 for MCI and Early Alzheimer's (Mission AD1)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, for The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

E2609 for MCI and Early Alzheimer's (Mission AD2)

Purpose: To evaluate the efficacy and safety of E2609, or elenbecestat, in older adults with mild cognitive impairment and mild Alzheimer's disease.

This Phase III study Is Testing The Efficacy And Safety Of The Experimental Drug E2609, Or Elenbecestat, For The Treatment Of Early Alzheimer's Disease In Older Adults With Mild Cognitive Impairment (MCI) Or Mild Alzheimer's Disease.

Early-Onset Alzheimer's Disease Genomic Study

Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.

This Study Will Collect Samples From People With Early-onset Alzheimer's Disease And Their Immediate Family Members to Better Understand How Changes In The Body Are Related To Development Of The Disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

This Study Will Test An Education And Skills-based Training Program For People With Early-stage Memory Loss Or Dementia And Their Care Partners. The Training Is Designed To Reduce Stress And Distress, And Increase Well-being And Quality Of Life.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

This Study Will Test The Hypothesis That The Presence Of Beta-amyloid Plaques In The Braina Hallmark Of Alzheimer's Diseasein Non-demented Older Patients Increases The Likelihood Of cognitive Decline After scheduled Hip Or Knee Replacement Surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

This Study Will Examine The Sensitivity Of Functional Magnetic Resonance Imaging (fMRI) To Detect Brain Changes In Healthy Older Adults At Genetic Risk For Alzheimer's Disease Who Take The Drug Donepezil (Aricept). Participants With A Family History Of Alzheimer's Are Eligible For This Study. Participants Without A Family History Of Alzheimer's Can Be enrolled To Serve As A Control Group.

Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.

In This Study Researchers Are Investigating How The Mediterranean Diet And Low-fat Eating Patterns Affect Cognitive Function And Other Measures, Such As Brain Volume And Blood Pressure, In Cognitively Normal Older Adults.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

This Study Will Evaluate The Safety And Efficacy Of Escitalopram (Lexapro) To Treat Agitation In Alzheimer's Disease.

Evaluation of an Online Decision Aid for Alzheimer's Genetic Testing

This Nationwide, Online-only Study Will Evaluate A Prototype Online Aid Designed To Help People Think Through Whether Or Not To Undergo Genetic Testing For Late-onset Alzheimer's Disease. Participants Will Examine The Prototype And Offer Feedback About Its Clarity And Helpfulness In Presenting Important Personal And Family Issues.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

The EASES Study Is A 2-year Observational Study Designed To Measure Brain Function During The Onset And Progression Of Mild Cognitive Impairment (MCI) In Older Adults using Quantitative Electroencephalography (qEEG).

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Physical Inactivity, High Blood Pressure, And High Cholesterol Levels Are Risk Factors For Alzheimer's Disease And Vascular Dementia; However, These Risk Factors Are Modifiable With Lifestyle Changes And Medications. This Study Will Test The Effects Of Aerobic Exercise And Vascular Risk Reduction On Cognitive Performance In Older Adults Who Are At Risk For Alzheimer's Disease.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

This Study Is Recruiting Older Adults Who Are Cognitively Healthy But Physically Inactive to Participate In An Intervention Comparing Aerobic Exercise And Flexibility Exercise And Their Effects On Memory And Brain Function.

Exercise in Adults with Mild Memory Problems (EXERT)

Purpose: To evaluate the effects of physical exercise on cognition, functional status, brain atrophy, blood flow, and cerebrospinal fluid biomarkers of Alzheimer's disease in adults with a mild memory impairment.

This Study Evaluates The Effects Of Physical Exercise On Cognition, Functional Status, Brain Atrophy, Blood Flow, And Cerebrospinal Fluid Biomarkers Of Alzheimer's Disease In Adults With A Mild Memory Impairment. Half Of Participants Will Participate In A Stretching-balance-range Of Motion Exercise Program, While The Other Half Will Participate In A Moderate- To High-intensity Aerobic Training Program.

Family Telemental Health Intervention for Veterans with Dementia

Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.

This Research Project Will Develop A Telehealth Intervention To Address Interpersonal Difficulties Between Caregivers And Persons With Dementia In Families With Veterans.

GRF6019 Infusions for Severe Alzheimer's Disease

Purpose: To evaluate the safety, tolerability, and potential cognitive benefit of the experimental treatment GRF6019 in older adults with severe Alzheimer's disease.

This Phase II Study Will Evaluate The Safety, Tolerability, And Potential Cognitive Benefit Of An Intraveneous Infusion Of GRF6019, A Plasma-derived Product, To Treat Older Adults With Severe Alzheimer's Disease.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

This Phase III Clinical Trial Will Evaluate The Efficacy And Safety Of Gantenerumab In People with Early-stage Alzheimer's Disease. Gantenerumab is An Experimental Medication That Is Being Investigated For Its Ability To Reduce Beta-amyloid Plaques In The Brain That Are associated With Alzheimer's Disease. This Trial Is Similar To Safety And Efficacy Of Gantenerumab For Early Alzheimer's, But Recruiting In Different Locations.

GeneMatch

Purpose: To identify people interested in participating in research studies or clinical trials based in part on their genetic background.

The GeneMatch Program, Part Of The Alzheimer's Prevention Registry, Aims To Identify People Interested In Participating In Research Studies Or Clinical Trials Based In Part On Their Genetic Background. GeneMatch Will Collect Genetic Information From Participants Which May Be Used To Match Them To Studies. Participants Are Under No Obligation To Pursue These Study Opportunities.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

This Long-term Study Will Help Researchers Learn More About Biomarkers—substances In Human Blood And Tissues—and Their Relationship To Aging. The Goal Is To Find Ways To Improve Quality Of Life In Old Age.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

In This Observational Study, Scientists Will Examine The Genes Of Families With A History Of Movement Disorders (such As Parkinson's Disease, Amyotrophic Lateral Sclerosis (ALS), Ataxia, Corticobasal Degeneration, Dystonia, Essential Tremor, And Huntington's Disease) And Dementias (such As Alzheimer's Disease, Lewy Body Dementia, And Frontotemporal Dementia) To Try To Find a Genetic Cause Of These Disorders. People With Any Movement Disorder Or Dementia And Their Family Members Are Invited To Participate.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

This Exploratory Trial Will Investigate The Effects Of A Glutathione Dietary Supplement On Cognitive Function In Adults With Mild Cognitive Impairment (MCI).

Grape Seed Extract for Alzheimer's Disease

Purpose: To establish the safety and pharmacokinetics of grape seed extract and to test its cognitive effects in people with Alzheimer's disease.

This Phase II Clinical Trial Will Establish The Safety And Pharmacokinetics Of A Grape Seed Extract, Meganatural-Az, And Test Its Effects On Cognition In People With Alzheimer's Disease. This Extract Is Thought To Act On Tau Tangles, A Protein Accumulation Seen In The Brain Of People With Alzheimer's.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

This Study Is Recruiting Adults With Or Without Neurological Or Psychiatric Conditions To Test An IPad Application Being Developed To Help Detect Neurocognitive Disorders, Such As Alzheimer's Disease And Related Dementias. 

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

This Study Will Test The Ability Of The Radioactive Tracer 11C-ER176 To Stick To Parts Of The Brain Where There Is Inflammation. Past Studies Have Shown That Inflammation Is Present In The Brains Of People With Alzheimer's Disease.

Improving Well-Being for Older Adult Family Dementia Caregivers

Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.

This Study Will Examine The Effects Of Two Interventions, The Mindfulness-Based Stress Reduction (MBSR) Program And The Living Well Program, On Immune Function, Physical And Emotional Health, And Well-being of Older Adults Who Care For A Family Member With dementia.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

This Study Will Test Dance And Social Engagement As A Method To Decrease Behavioral Symptoms And Improve Quality Of Life In Older Adults With Mild Cognitive Impairment (MCI) Or Early Alzheimer's Disease.

Independent Walking in Older Adults for Brain Health

Purpose: To test the use of mobile health devices in helping older adults independently walk to improve cognitive health.

This Study Uses Mobile Health Devices To Help Physically Inactive, Cognitively Normal Older Adults Walk, With The Aim Of Preserving Cognitive Function.

Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE)

Purpose: To test the effect of a telephone-based intervention on reducing the burdens of dementia-associated symptoms and behaviors.

The 2-year IN-PEACE Study Is Recruiting Patient-caregiver Pairs To Help Test A Telephone-based Intervention Involving Regular, Proactive Contact By A Dementia Care Coordinator To Anticipate And Identify Patients' Symptoms And Caregivers' Needs And Help Address Those Needs.

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.