Clinical Trials Search Result

4 Repeat Tauopathy Neuroimaging Initiative

Purpose: To identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time.

4 Repeat Tauopathy Neuroimaging Initiative Cycle 2 (4RTNI-2)

Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.

AGB101 for Mild Cognitive Impairment Due to Alzheimer's Disease

Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.

AGB101 for Preclinical Alzheimer's Disease

Purpose: To test whether the investigational drug AGB101 can reduce abnormal hyperfunctional activity in the hippocampus in healthy adults who are APOE 4 carriers.

AHEAD Study: BAN2401 for People With Increased Risk of Alzheimer's Disease

Purpose: To determine whether treatment with BAN2401 reduces brain amyloid accumulation in people with an increased risk for Alzheimer's disease.

AL001 for Frontotemporal Dementia

Purpose: To evaluate the safety and tolerability of AL001 in participants with frontotemporal dementia caused by a granulin mutation or C9orf72 mutation.

A-LIST: Patients and Families Transforming Alzheimer's Disease

Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.

ARTFL-LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD) Research Consortium

Purpose: To collect and study data from people with frontotemporal lobar degeneration and their family members to understand changes in brain function and biomarkers as the disease progresses.

ATH-1017 for Mild to Moderate Alzheimer's Disease

Purpose: To test the safety and effectiveness of the drug ATH-1017 to treat mild to moderate Alzheimer's disease.

AVP-786 for the Treatment of Agitation in Alzheimer's

Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.

Adult Day Plus Program for Family Caregivers

Purpose: To evaluate the effectiveness of an adult day services program to improve the well-being of caregivers of older adults with Alzheimer's disease.

Advance Care Planning for People With Cognitive Impairment

Purpose: To test the effectiveness of a program to improve the quality of communication about medical and end-of-life care among patients with cognitive impairment, their family, and their doctors.

Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)

Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.

Aerobic Exercise and Cognitive Training for MCI (ACT Trial)

Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.

African Dance for African American Cognitive Health

Purpose: To test the effects of African dance on mild cognitive impairment in African Americans.

Aging-Well: Remote Monitoring for Adults at Risk for Alzheimer's Disease

Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.

Alzheimer Prevention Trials (APT) Webstudy

Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.

Alzheimer's Biomarkers Consortium-Down Syndrome

Purpose: To identify biomarkers to help track the development and progression of Alzheimer's disease in people with Down syndrome.

Alzheimer's Disease, Caregiving, and Social Networks

Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.

Alzheimer's Disease Discovery Study (ASSIST)

Purpose: To gather health and behavioral data using a mobile health app to identify the relationships between lifestyle choices and the risk for developing Alzheimer's.

Alzheimer's Disease Genetics Study

Purpose: To identify the genes that cause late-onset Alzheimer's disease.

Alzheimer's Disease Neuroimaging Initiative 3 (ADNI3)

Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.

Alzheimer's Prevention Registry

Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

Amyotrophic Lateral Sclerosis (ALS) Families Project

Purpose: To learn how and why motor neuron degeneration begins and progresses in families affected by familial amytrophic lateral sclerosis (ALS).

Augmenting Cognitive Training in Older Adults (ACT)

Purpose: To investigate the effects of combined cognitive training and transcranial direct current stimulation on cognition and brain function in older adults.

BAN2401 for People with Early Alzheimer's Disease (Clarity AD)

Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease.

BDPP Treatment for Mild Cognitive Impairment and Prediabetes

Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.

B-Fit Intervention to Improve Brain Health

Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.

Biomarker Predictors of Memantine Sensitivity

Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.

Biomarkers in Lewy Body Dementia

Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.

Blood Pressure Control to Reduce Amyloid-Beta Accumulation (HIPAC)

Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.

Blood-Brain Barrier Permeability Imaging for Early Alzheimer's

Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.

Bosutinib for the Treatment of Dementia with Lewy Bodies

Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.

Brain Aging in Vietnam War Veterans (DOD-ADNI)

Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.

Brain Care for Veterans with Alzheimer's or Traumatic Brain Injury (ABC ANSWERS)

Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.

Brain Energy for Amyloid Transformation in Alzheimer's Disease (BEAT-AD)

Purpose: To compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.

Brain Energy Metabolism and Sleep in Adults

Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.

Brain Health Registry

Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

Brain Safe: Reducing Exposure to Drugs Linked to Alzheimer's

Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.

Brain Wave Stimulation for Frontotemporal Dementia

Purpose: To test the effects of daily brain stimulation on cognition in people with behavioral variant frontotemporal dementia.

Brexpiprazole for Agitation in Alzheimer's

Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.

Bryostatin for Moderate or Severe Alzheimer's Disease

Purpose: To test the safety, tolerability, and long-term effects of bryostatin for the treatment of moderately severe Alzheimer's disease.

CARE Registry for Asian Americans and Pacific Islanders

Purpose: To enroll Asian, Asian Americans, and Pacific Islanders who are interested in participating in research on Alzheimer's disease and related dementias, aging, and caregiving.

CORT108297 for People at Increased Risk for Alzheimer's

Purpose: To test whether the drug CORT108297 improves cognition in people at risk for developing Alzheimer's disease.

CPAP Treatment of Obstructive Sleep Apnea for MCI

Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.

Calorie Restriction and Brain Function in Mild Cognitive Impairment

Purpose: To test the effects of intermittent calorie restriction in older adults with mild cognitive impairment who are overweight or obese.

Care Partners Program for Alzheimer's Disease

Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.

Caregiver Outcomes of Alzheimer's Disease Screening

Purpose: To measure the risks and benefits of early screening for Alzheimer's disease in terms of its effects on family caregivers.

Caring Response: A Mobile Training App for Family Caregivers

Purpose: To determine if the mobile training app, Caring Response, can improve coping skills and quality of life for family caregivers of someone with Alzheimer's disease.

Cerebrospinal Fluid Clearance in Preclinical Alzheimer's Disease

Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).

Cleveland Clinic Healthy Brains Registry

Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.

Coaching for Cognition in Alzheimer's and MCI (COCOA)

Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.

Cognitive Rehabilitation for Older Veterans with MCI

Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.

Cognitive Training for Older Caregivers

Purpose: To test whether computer-based brain training activities can promote cognitive, emotional, and physical health in older adult caregivers of a spouse or significant other with dementia.

Community Paramedic Coaching Program for Caregivers and People with Dementia

Purpose: To evaluate the effectiveness of a community paramedic coaching program for caregivers of people with dementia.

Computerized Screening Tool for Cognitive Decline

Purpose: To test a computerized screening tool to detect early cognitive decline in older adults during their doctor's visits.

Cortical Stimulation for Mild Cognitive Impairment

Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.

DC Longitudinal Study on Aging and Specimen Bank

Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.

D-CARE: The Dementia Care Study

Purpose: To compare the effectiveness of two evidence-based models of dementia care.

Dapagliflozin in Alzheimer's Disease

Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.

Deep Brain Stimulation in Mild Alzheimer's Disease (ADvance II Study)

Purpose: To test deep brain stimulation of the fornix as a treatment for Alzheimer's disease.

Delivery of Essential Fatty Acids to the Brain

Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.

Dementia Caregiver Chronic Grief Management: A Live Online Video Intervention

Purpose: To test an online group intervention for decreasing caregivers' grief, depression, anxiety, and conflict after their family member transitions to a long-term care facility.

Diet and Cognitive Training for Mild Cognitive Impairment

Purpose: To test whether the MIND diet combined with Brain HQ cognitive brain training exercises improves cognitive performance in older adults.

Dietary Influences on Alzheimer's Biomarkers

Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.

Dietary Intervention in Cognitive Aging

Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.

Dietary Modulation of Neuroinflammation in Age-Related Memory Disorders

Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.

Digital Memory Notebook App for Functional Independence

Purpose: To test the efficacy of smart home/digital memory notebook technology to improve independence in adults with memory problems.

Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

Dominantly Inherited Alzheimer Network (DIAN)

Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

Dominantly Inherited Alzheimer Network Trial Unit (DIAN-TU)

Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.

Donanemab for Early-Stage Alzheimer's Disease

Purpose: To test the safety and effectiveness of donanemab to reduce cognitive decline and amyloid plaque in people with early-stage Alzheimers disease.

Down Syndrome Clinical Trials Network-Study of Alzheimer's Disease

Purpose: To better understand the cognitive and behavioral changes and health issues found in adults with Down syndrome as they progress toward Alzheimers disease.

Dronabinol to Treat Agitation in Alzheimer's Disease

Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.

Early-Onset Alzheimer's Disease Genomic Study

Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.

Early-Stage Partners in Care for Memory Loss and Dementia (EPIC)

Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.

Effects of Brain Beta-Amyloid on Postoperative Cognition

Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

Effects of Donepezil Measured by Functional MRI

Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

Electrical Stimulation and Verbal Memory in Alzheimer's Disease

Purpose: To test transcranial direct current stimulation (tDCS) to slow nerve cell damage in the brain and improve verbal memory in people with Alzheimer's disease.

Enhanced Mediterranean Diet for Alzheimer's Disease Prevention

Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.

Escitalopram for Agitation in Alzheimer's Disease

Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.

Evaluation of an Online Decision Aid for Alzheimer's Genetic Testing

Purpose: To evaluate a prototype online aid designed to help people think through whether or not to undergo genetic testing for late-onset Alzheimer's disease.

Evidence Amyloid Scan EEG Study (EASES)

Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.

Exercise and Vascular Risk Reduction for Alzheimer's

Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.

Exercise Effects on Brain Health and Learning

Purpose: To understand and enhance the detection of exercise effects on hippocampal network function, learning and memory in older adults.

Exercise for Brain Health

Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.

Exercise to Improve Cognitive Function in Veterans with MCI

Purpose: To assess the feasibility of a home-based exercise intervention to improve memory in veterans with mild cognitive impairment.

FTD Disorders Registry

Purpose: To gather information from people affected by frontotemporal degeneration (FTD), including people diagnosed with FTD, caregivers, friends, and family, and provide information about FTD study opportunities.

Family Telemental Health Intervention for Veterans with Dementia

Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.

Gamma Induction for Alzheimer's Disease

Purpose: To test the effects of daily brain stimulation on levels of amyloid and tau in people with Alzheimer's disease.

Gantenerumab for Early Alzheimer's Disease

Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.

Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

Purpose: To learn more about biomarkers and their relationship to aging.

Genetic Characterization of Movement Disorders and Dementias

Purpose: To learn more about the genetic causes of movement disorders and dementias.

Glutathione for Mild Cognitive Impairment

Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.

Health Interventions for Distressed Dementia Caregivers

Purpose: To test the effectiveness of self-managed health interventions to improve the mental and physical health of highly stressed dementia caregivers.

Hearing Aids and Individuals with Cognitive Disorders

Purpose: To evaluate procedures that will help determine the impact of hearing aid interventions on older individuals with Alzheimer's disease and related dementias.

High-Dose Vitamin D Supplements in Older Adults

Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.

Home-Based Transcranial Direct Current Stimulation for Pain Management in People With Dementia

Purpose: To evaluate transcranial direct current stimulation for chronic pain management in people with early-stage Alzheimer's disease or a related dementia.

iPad App for Neurocognitive Testing

Purpose: To test an iPad application for measuring neurological functioning.

Imaging Inflammation in Alzheimer's Disease with 11C-ER176

Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.

Imaging of Brain Inflammation in People With Alzheimer's Disease

Purpose: To determine how inflammation is related to other changes in the brain that occur in Alzheimer's disease.

Improving Well-Being for Older Adult Family Dementia Caregivers

Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.

Improvisational Movement for People with Memory Loss and Their Caregivers (IMOVE)

Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment

Purpose: To develop and evaluate an in-home supportive technology to help alleviate anxiety, burden, and loneliness in family caregivers of people with Alzheimer's disease, related dementias, or mild cognitive impairment.

In-Home Technology for Dementia Caregivers

Purpose: To develop and evaluate in-home assistive technology to alleviate anxiety, burden, and loneliness in caregivers of people with Alzheimer's disease and frontotemporal dementia.

Indiana Palliative Excellence in Alzheimer's Care Efforts (IN-PEACE)

Purpose: To test the effect of a telephone-based intervention on reducing the burdens of dementia-associated symptoms and behaviors.

Individualized Online Care Planning Tool for Family Members of Persons With Dementia

Purpose: To test an online care planning tool designed to provide individualized information to better serve the diverse needs of caregivers and care recipients living with Alzheimer's disease or a related dementia.

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.

Innovations in Dementia Empowerment and Action

Purpose: To test a tailored behavioral intervention for LGBT individuals with Alzheimer's disease or a related dementia and their caregivers.

Insomnia Therapy for People Living With Dementia and Their Caregivers

Purpose: To test cognitive behavioral therapy for insomnia to improve the sleep of community-dwelling persons living with dementia and their caregivers.

Insulin Delivery for Memory Loss

Purpose: To test the effects of insulin delivered through the nose on memory in older adults.

Intermittent Calorie Restriction, Insulin Resistance, and Brain Function

Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.

Internet-Based Conversational Engagement Clinical Trial (I-CONECT)

Purpose: To examine whether increasing social interaction through face-to-face web-based conversations could improve cognitive function in older adults who are socially isolated.

Interventions for Circadian Rhythm Disorders in Dementia (Healthy Patterns Sleep Study)

Purpose: To evaluate a program of activities to improve symptoms of disturbed sleep-wake cycles in people with dementia who live at home.

Interventions for People with Alzheimer's Disease and Dysphagia (Swallowing Problems)

Purpose: To develop effective interventions that improve swallowing for people with Alzheimer's Disease at risk for pneumonia.

Intranasal Oxytocin for Frontotemporal Dementia

Purpose: To test the safety and effectiveness of oxytocin given by a spray into the nose, to decrease apathy and other behavioral symptoms in people with frontotemporal dementia.

Investigating Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.

Investigating Gains in Neurocognition in an Intervention Trial of Exercise (IGNITE)

Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.

K0706 for Dementia with Lewy Bodies

Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.

Language in Primary Progressive Aphasia

Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

Lenalidomide for Amnestic Mild Cognitive Impairment

Purpose: To test whether lenalidomide reduces inflammation and improves cognition in people with amnestic mild cognitive impairment.

Leuprolide Plus Cholinesterase Inhibition to Reduce Neurological Decline in Alzheimer's (LUCINDA)

Purpose: To test leuprolide acetate (Eligard) in women with Alzheimer's disease taking a stable dose of donepezil (Aricept.)

Lifestyle Activities for Brain Health

Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Lifestyle Changes To Slow Progression of Early-Stage Alzheimer's Disease

Purpose: To determine whether comprehensive lifestyle changes, such as diet and exercise, may slow, stop, or reverse the progression of early-stage Alzheimer's disease.

Light and Cognitive Therapy for Alzheimer's Disease

Purpose: To test an iPad app that delivers light therapy at 40 Hz, combined with cognitive therapy, to improve cognition in people with Alzheimer's.

Light for Metabolic Syndrome and Alzheimer's

Purpose: To test the effects of a tailored lighting system on sleep, mood, inflammation, and glucose tolerance in older adults with Alzheimer's disease or a related dementia and type 2 diabetes.

Light, Metabolic Syndrome, and Alzheimer's Disease

Purpose:: To test the long-term effect of a light treatment on cognition, sleep, and metabolism in people with MCI, mild Alzheimer's disease, or a related dementia.

Lithium to Prevent or Delay Dementia

Purpose: To test lithium as a treatment that may prevent or delay dementia in people with mild cognitive impairment.

Longitudinal Early-Onset Alzheimer's Disease Study (LEADS)

Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.

Longitudinal Innate Immunity and Aging Study (LIIA)

Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.

Lu AF87908 for Alzheimer's Disease

Purpose: To evaluate the safety and tolerability of Lu AF87908 in healthy participants and participants with Alzheimer's disease.

MRI and PET Biomarkers for Cognitive Decline in Older Adults

Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.

MRI-Guided Transcranial Magnetic Stimulation for MCI

Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.

MW151 to Treat Cognitive Disorders

Purpose:: To test the safety and efficacy of MW151 to treat cognitive disorders.

Melatonin for Cognition and Brain Health in Aging

Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.

Memory Improvement Through Nicotine Dosing (MIND)

Purpose: To test the effects of a nicotine skin patch on memory performance in older adults with mild cognitive impairment (MCI).

Middle-Aged Offspring of Late Alzheimer's Probands: Novel Cognitive and Biomarker Assessment (O-LOAD)

Purpose: To study imaging differences between children of parents with and without late-onset Alzheimer's disease.

Mind-Body Interventions for Healthy Aging

Purpose: To examine the impact of mind-body interventions on neurocognitive and emotional functioning in older adults.

Mind-Body Skills and Physical Activity for MCI and Chronic Pain

Purpose: To adapt and examine a mind-body program, called Active Brains, to meet the needs of older adults with chronic pain and mild cognitive impairment.

MindCrowd

Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

Mindfulness to Reduce Loneliness in Older Dementia Caregivers

Purpose: To test the effectiveness of mindfulness training to reduce social isolation and feelings of loneliness in older caregivers of family members with Alzheimer's disease or a related dementia.

Mindfulness Training for African American Dementia Caregivers

Purpose: To assess telephone-based mindfulness training to alleviate caregiver burden for African American rural caregivers of people with moderate to severe dementia.

Mobile App to Monitor Dementia-Related Agitation

Purpose: To test a mobile application designed to monitor and support individuals with dementia-related agitation.

Mobile Web-based Behavioral Intervention for Improving Caregiver Well-being

Purpose: To test a mobile-based web intervention designed to reduce dementia caregiver distress and improve overall well-being.

Modified Story Memory Technique (mSMT) to Enhance Memory

Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.

Montelukast Therapy for Alzheimer's Disease

Purpose: To test montelukast as a treatment for people with mild cognitive impairment and early Alzheimer's dementia.

Multicultural Healthy Diet to Reduce Cognitive Decline

Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.

NNI-362 in Healthy Older Adults

Purpose: To examine the safety of single and multiple doses of the investigational drug NNI-362 in healthy older adults as a potential treatment for Alzheimer's disease.

Natural History Study of Synucleinopathies

Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).

Near-Infrared Stimulation for Mild Cognitive Impairment

Purpose: To test whether near-infrared light stimulation can improve cognition in older adults with mild cognitive impairment.

Network Modulation in Alzheimer's Disease

Purpose:: To assess the effects of noninvasive brain stimulation on memory and language ability in people with amnestic mild cognitive impairment or the logopenic variant of primary progressive aphasia.

Neurofilament Biomarker for Frontotemporal Lobar Degeneration

Purpose: To determine if neurofilament light chain can be used as an early biomarker for frontotemporal lobar degeneration.

Nicotinamide as an Early Alzheimer's Treatment (NEAT)

Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.

Nicotinamide Riboside for Mild Cognitive Impairment

Purpose: To test the effects of the supplement nicotinamide riboside on memory and brain blood flow in older adults with mild cognitive impairment.

Nighttime Agitation and Restless Legs Syndrome in Nursing Home Residents with Alzheimer's

Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.

Nilotinib for Dementia with Lewy Bodies

Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.

North American Prodromal Synucleinopathy (NAPS) Consortium

Purpose: To enroll adults with rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.

Novel Computerized Cognitive Stress Test

Purpose: To examine the Cognitive Stress Test in distinguishing between early-stage mild cognitive impairment and cognitively normal older adults.

Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD)

Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.

Older Adults with Cognitive Impairment Living Alone

Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.

Omega-3 Fatty Acid in Veterans at Risk for Alzheimer's

Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.

Online Self-Management Workshop for Rural Dementia Caregivers

Purpose: To evaluate an interactive, online workshop designed to support isolated dementia caregivers in rural areas and reduce caregiver stress and depression.

Online Support and Skills Training for Dementia Caregivers

Purpose: To test the effectiveness of GamePlan4Care (GP4C), an evidence-based, online system designed to provide accessible, tailored caregiver support and skills training.

Online Training for Alzheimer's Caregivers

Purpose: To test the effectiveness of an online training program for family caregivers of someone with mid-stage Alzheimer's disease.

Online Yoga for Chronic Pain in People With Alzheimer's

Purpose: To test the feasibility of conducting a study using online yoga to reduce chronic pain for people with Alzheimer's disease.

Oral Hygiene in Assisted Living

Purpose: To evaluate a program that provides daily mouth care for assisted living residents with dementia.

PET Imaging of Neuroinflammation in Neurodegenerative Diseases

Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.

PTI-125 for Older Adults With Mild to Moderate Alzheimer's Disease

Purpose: To study the safety of PTI-125 medication and its effect on biomarkers, cognition, and neuropsychiatric symptoms in older adults with Alzheimer's disease.

Palliative Care for Cognitively Impaired People and Their Families

Purpose: To evaluate the benefits of an early palliative-care intervention for people with cognitive impairment and their family caregivers.

Partnered Rhythmic Rehabilitation in People With Mild Cognitive Impairment

Purpose: To determine whether partnered rhythmic rehabilitation, which targets fitness, cognition, mobility, and social engagement, may prevent future functional problems in people with mild cognitive impairment due to Alzheimer's disease.

Physical Activity and Alzheimer's Disease (PAAD-2)

Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.

Pimavanserin for Psychological Symptoms of Dementia

Purpose: To determine whether treatment with the drug pimavanserin decreases the psychological symptoms of dementia in older adults.

Posiphen for Early-Stage Alzheimer's and Parkinson's Diseases

Purpose: To determine the safety and tolerability of Posiphen in people with early Alzheimer's or early Parkinson's disease.

Posiphen in Early Alzheimer's Disease (Discover Study)

Purpose: To evaluate Posiphen^® in older adults with early-stage Alzheimer’s disease.

Positive Emotion Skills Training for Family Caregivers

Purpose: To test whether the practice of positive emotions can increase caregiver well-being and decrease the stress of caregiver burden.

Practice of Acceptance, Awareness, and Compassion in Caregiving (PAACC)

Purpose: To evaluate a mindfulness-based intervention for caregivers of people with dementia.

Prazosin in Veterans with Mild Traumatic Brain Injury

Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.

Precision Rehabilitation to Counteract Age-Related Cognitive Decline

Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.

Problem Adaptation Therapy for Mild Cognitive Impairment and Depression

Purpose: To compare Problem Adaptation Therapy to Supportive Therapy for improving cognitive, affective and functioning outcomes in people with mild cognitive impairment.

Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

Psychotherapy to Promote Social Connection in Caregivers

Purpose: To determine if the Social Engage behavioral intervention can effectively increase social connection for dementia caregivers.

Reducing Sedentary Behavior to Improve Cognition in Older Latinos

Purpose: To test whether a wearable device can decrease sedentary behavior, or inactivity, in older Latinos and whether increased activity improves cognitive function.

Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia

Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.

Reliability of the Human Brain Connectome

Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

ResearchMatch

Purpose: To connect people interested in health research with studies that match their interests.

Retinal Imaging for Mild Cognitive Impairment and Alzheimer's Disease

Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.

Retinal Imaging for the Diagnosis of Cognitive Disorders and Dementia

Purpose: To test the effectiveness of a retinal imaging system to measure changes in the eye to diagnose cognitive disorders and dementia.

Rocky Mountain Alzheimer's Disease Center Longitudinal Biomarker and Clinical Phenotyping Study

Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.

Role of the Nicotinic System in Cognitive Aging

Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.

S-Equol for Alzheimer's Disease

Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.

SPIRIT for End-of-Life Decision Making in Mild Alzheimer's

Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild dementia and their surrogates to promote end-of-life care discussions.

Sensory Enrichment for Older Adults

Purpose: To evaluate the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.

Skills Training for Caregivers of People With Primary Progressive Aphasia

Purpose: To adapt and test the Tele-Savvy online caregiver training program to address the unique challenges of caregiving for a person with primary progressive aphasia.

Skills Training for LGBT Dementia Caregivers

Purpose: To test the design of a caregiver training program developed to address the unique challenges facing lesbian, gay, bisexual, and transgender (LGBT) caregivers of a person living with dementia.

Sleep Intervention for People with Alzheimer's Disease and Their Caregivers

Purpose: To develop a sleep intervention program for people with Alzheimer's disease and their caregivers, who both experience sleep difficulties.

Sleep Intervention to Enhance Cognitive Status and Reduce Beta-Amyloid (SIESTA)

Purpose: To test the effects of cognitive behavioral training for insomnia (CBT-I) in older adults with symptoms of insomnia.

SmartPrompt Electronic Reminder Aid to Improve Everyday Function in People With Dementia

Purpose: To evaluate the use of SmartPrompt, a smartphone-based electronic reminder aid that is designed to help older adults with dementia perform daily tasks.

Speech Language Therapy for Primary Progressive Aphasia

Purpose: To evaluate two evidence-based speech language therapy treatments for adults with mild primary progressive aphasia.

Stimulation to Improve Memory

Purpose: To learn about the effects of weak electrical stimulation on brain functioning in people with mild cognitive impairment.

Strategic Training to Optimize Neurocognitive Functions in Older Adults

Purpose: To evaluate the efficacy of a novel cognitive training approach in older adults using simulated games.

Strawberry Powder for Memory and Mobility in Obese Older Adults

Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.

Stress Management for Dementia Caregivers

Purpose: To determine the effect of dementia caregiver preferences on stress management interventions.

Stress Reduction for Partners of People With Early-Stage Dementia

Purpose: To test whether the Wish Outcome Obstacle Plan lowers the stress of partners and spouses of people with early-stage dementia.

Study to Evaluate Amyloid in Blood and Imaging Related to Dementia (SEABIRD)

Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.

Studying the Role of Inflammation in Parkinson's and Alzheimer's diseases

Purpose: To better understand the role of the immune response, including inflammation, in Parkinson's disease (PD) and Alzheimer's disease (AD).

Synexus HealthyMinds Registry

Purpose: To enroll older adults in an online study tracking healthy brain aging.

TMS and Language Therapy for Verbal Communication Problems in Alzheimer's Disease

Purpose: To test the effectiveness of transcranial magnetic stimulation combined with language therapy to improve verbal communication in people with Alzheimers disease.

Tai Ji Quan and Cognitive Function in Mild Cognitive Impairment

Purpose: To determine the effects of a cognitively enhanced tai ji quan exercise intervention in improving cognitive function and dual-task ability in older adults with mild cognitive impairment.

Targeting Verbal Short-Term Memory in Conjunction with tDCS in Neurodegenerative Disorders

Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.

Tau Kinetics in Healthy Aging and Alzheimer's Disease

Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.

Tau PET Imaging and Cognition

Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.

Tau PET Imaging for Primary Progressive Aphasia

Purpose: To test a radioactive tracer, 18F-AV-1451, for showing tau protein patterns on brain scans of people with primary progressive aphasia.

Tau PET Imaging Tracer for Alzheimer's Disease

Purpose: To test a radioactive tracer, 18F-APN-1607, for showing tau protein patterns on brain scans of people with Alzheimer's disease.

Telephone Therapy for Alzheimer's Caregivers

Purpose: To test a telephone-based behavioral intervention designed to reduce anxiety and associated psychological distress in dementia caregivers.

Telmisartan to Prevent Alzheimer's in African Americans

Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.

The Role of Gut Flora in Alzheimer's Disease

Purpose: To correlate microbiome data with information about Alzheimer's disease.

The STELLA Collaborative: Using Technology to Advance Alzheimer's Disease and Related Dementias Family Education and Support

Purpose: To study the use of a videoconference-based system known as Support via Technology: Living and Learning with Advancing Alzheimer's Disease and Related Dementias to provide education and support to family caregivers, as well as the person with dementia.

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