Find Alzheimer’s Disease and Related Clinical Trials
Search for clinical trials and studies related to Alzheimer's, other dementias, mild cognitive impairment, and caregiving.
Results found: 239
Purpose: To identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time.
Purpose: To identify reliable methods for tracking corticobasal degeneration and progressive supranuclear palsy.
Purpose: To evaluate the efficacy of AGB101 in slowing cognitive and functional impairment in people with mild cognitive impairment (MCI) due to Alzheimer's.
Purpose: To test whether the investigational drug AGB101 can reduce abnormal hyperfunctional activity in the hippocampus in healthy adults who are APOE 4 carriers.
Purpose: To determine whether treatment with BAN2401 reduces brain amyloid accumulation in people with an increased risk for Alzheimer's disease.
Purpose: To evaluate the safety and tolerability of AL001 in participants with frontotemporal dementia caused by a granulin mutation or C9orf72 mutation.
Purpose: To increase patient and caregiver engagement in research by gathering insights through regular surveys.
Purpose: To collect and study data from people with frontotemporal lobar degeneration and their family members to understand changes in brain function and biomarkers as the disease progresses.
Purpose: To test the safety and effectiveness of the drug ATH-1017 to treat mild to moderate Alzheimer's disease.
Purpose:To evaluate AVP-786, compared to placebo, for the treatment of agitation in people with Alzheimer's-type dementia.
Purpose: To evaluate the effectiveness of an adult day services program to improve the well-being of caregivers of older adults with Alzheimer's disease.
Purpose: To test the effectiveness of a program to improve the quality of communication about medical and end-of-life care among patients with cognitive impairment, their family, and their doctors.
Purpose: To build a clinical research consortium to test new treatments for people with frontotemporal lobar degeneration.
Purpose: To test the combined effects of aerobic exercise and cognitive training on cognition, fitness, and brain structure and function in older adults with mild cognitive impairment.
Purpose: To test the effects of African dance on mild cognitive impairment in African Americans.
Purpose:To test home sensors for capturing changes in daily activities that may signal the onset of cognitive or functional decline in older adults with and without mild cognitive impairment.
Purpose: To accelerate enrollment for Alzheimer's disease clinical trials by identifying and tracking individuals who may be at higher risk for developing Alzheimer's dementia.
Purpose: To identify biomarkers to help track the development and progression of Alzheimer's disease in people with Down syndrome.
Purpose: To study how multiple family members provide care for a person with Alzheimer's disease.
Purpose: To gather health and behavioral data using a mobile health app to identify the relationships between lifestyle choices and the risk for developing Alzheimer's.
Purpose: To identify the genes that cause late-onset Alzheimer's disease.
Purpose: To determine the relationships among clinical, cognitive, imaging, genetic, and biomarker characteristics of the entire spectrum of Alzheimer's disease.
Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.
Purpose: To learn how and why motor neuron degeneration begins and progresses in families affected by familial amytrophic lateral sclerosis (ALS).
Purpose: To investigate the effects of combined cognitive training and transcranial direct current stimulation on cognition and brain function in older adults.
Purpose: To test the experimental drug BAN2401 in people with early Alzheimer's disease.
Purpose: To study the use of a nutraceutical drink to improve cognition in people with mild cognitive impairment and prediabetes.
Purpose: To evaluate a brain fitness intervention for improving cognitive health in middle-aged and older adults.
Purpose: To test the effects of the medication memantine on brain functions and the symptoms of Alzheimer's disease.
Purpose: To develop better measures for diagnosis and treatment of Lewy body dementia by studying older adults with the condition.
Purpose: To determine if lowering blood pressure using antihypertensive drugs alters brain pulsatility, a measure of blood flow, and reduces beta-amyloid accumulation in the brains of cognitively normal older adults.
Purpose: To test an imaging method for detecting the disruption of the blood-brain barrier in adults with and without cognitive impairment.
Purpose: To evaluate the drug bosutinib as a treatment for people with dementia with Lewy bodies.
Purpose: To study brain changes in veterans with traumatic brain injury or post traumatic stress disorder, with and without mild cognitive impairment.
Purpose: To test an intervention for caregivers of veterans with Alzheimer's disease or traumatic brain injury.
Purpose: To compare the effects of a ketogenic low-carbohydrate diet and a low-fat diet in adults with mild cognitive impairment.
Purpose: To explore the relationship of brain energy metabolites, genetic variations, and sleep patterns in the development of Alzheimer's disease.
Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.
Purpose: To evaluate the effectiveness of the Brain Safe application in reducing older adults' exposure to prescription anticholinergics.
Purpose: To test the effects of daily brain stimulation on cognition in people with behavioral variant frontotemporal dementia.
Purpose: To compare the efficacy of two doses of brexpiprazole (Rexulti) in older adults with agitation associated with Alzheimer's disease.
Purpose: To test the safety, tolerability, and long-term effects of bryostatin for the treatment of moderately severe Alzheimer's disease.
Purpose: To enroll Asian, Asian Americans, and Pacific Islanders who are interested in participating in research on Alzheimer's disease and related dementias, aging, and caregiving.
Purpose: To test whether the drug CORT108297 improves cognition in people at risk for developing Alzheimer's disease.
Purpose: To determine whether treatment of obstructive sleep apnea with continuous positive airway pressure therapy can delay the progression of cognitive impairment in older adults with mild cognitive impairment.
Purpose: To test the effects of intermittent calorie restriction in older adults with mild cognitive impairment who are overweight or obese.
Purpose: To develop and test a tablet-based caregiving program for family caregivers of people with Alzheimer's disease.
Purpose: To measure the risks and benefits of early screening for Alzheimer's disease in terms of its effects on family caregivers.
Purpose: To determine if the mobile training app, Caring Response, can improve coping skills and quality of life for family caregivers of someone with Alzheimer's disease.
Purpose: To measure cerebrospinal fluid clearance in the brain using positron emission tomography (PET).
Purpose: To enroll people in a registry that includes an online brain health assessment tool and information on clinical studies.
Purpose: To evaluate the effects of health coaching in addition to routine care for adults with mild cognitive impairment and Alzheimer's disease.
Purpose: To test the effectiveness of a cognitive rehabilitation group treatment for older veterans with mild cognitive impairment.
Purpose: To test whether computer-based brain training activities can promote cognitive, emotional, and physical health in older adult caregivers of a spouse or significant other with dementia.
Purpose: To evaluate the effectiveness of a community paramedic coaching program for caregivers of people with dementia.
Purpose: To test a computerized screening tool to detect early cognitive decline in older adults during their doctor's visits.
Purpose: To test repetitive transcranial magnetic stimulation as a treatment for adults with mild cognitive impairment.
Purpose: To determine the feasibility of various diagnostic tests for Alzheimer's disease, mild cognitive impairment, and other neurodegenerative diseases.
Purpose: To compare the effectiveness of two evidence-based models of dementia care.
Purpose: To test the effects of the drug dapagliflozin in adults with mild to moderate Alzheimer's disease.
Purpose: To test deep brain stimulation of the fornix as a treatment for Alzheimer's disease.
Purpose: To identify whether carrying the APOE 4 allele is associated with reduced delivery of DHA, an omega-3 fatty acid, to the brain in cognitively healthy older individuals.
Purpose: To test an online group intervention for decreasing caregivers' grief, depression, anxiety, and conflict after their family member transitions to a long-term care facility.
Purpose: To test whether the MIND diet combined with Brain HQ cognitive brain training exercises improves cognitive performance in older adults.
Purpose: To test how different types of meals affect Alzheimer's biomarkers in healthy older adults with and without the APOE E4 genotype.
Purpose: To test two dietary interventions in overweight, middle-aged individuals with subjective memory complaints.
Purpose: To test the effects of a cocoa-derived dietary supplement on brain structures, cognition, and inflammation in older adults with normal cognition.
Purpose: To test the efficacy of smart home/digital memory notebook technology to improve independence in adults with memory problems.
Purpose: To characterize the clinical, neuropsychological, sleep, and neuroimaging findings among adults with Alzheimer's disease, Lewy body dementia, and Parkinson's disease.
Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Purpose: To assess the safety, tolerability, and efficacy of investigational treatments in people who have an Alzheimer's disease-causing genetic mutation.
Purpose: To test the safety and effectiveness of donanemab to reduce cognitive decline and amyloid plaque in people with early-stage Alzheimers disease.
Purpose: To better understand the cognitive and behavioral changes and health issues found in adults with Down syndrome as they progress toward Alzheimers disease.
Purpose: To test the safety and efficacy of dronabinol to treat agitation in older adults with Alzheimer's.
Purpose: To better understand how changes in the body are related to the development of early-onset Alzheimer's disease.
Purpose: To test training for care partners and people with early-stage memory loss or dementia to reduce stress and increase well-being and quality of life.
Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.
Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).
Purpose: To test transcranial direct current stimulation (tDCS) to slow nerve cell damage in the brain and improve verbal memory in people with Alzheimer's disease.
Purpose: To learn how certain dietary patterns affect memory and cognitive function in cognitively normal older adults.
Purpose: To evaluate the safety and efficacy of escitalopram (Lexapro) to treat agitation in Alzheimer's disease.
Purpose: To evaluate a prototype online aid designed to help people think through whether or not to undergo genetic testing for late-onset Alzheimer's disease.
Purpose: To measure brain function during the onset and progression of mild cognitive impairment using a device that maps activity in the brain.
Purpose: To test the effects of exercise and vascular risk reduction on cognitive performance in older adults at high risk for Alzheimer's.
Purpose: To understand and enhance the detection of exercise effects on hippocampal network function, learning and memory in older adults.
Purpose: To compare the effects of moderate- and low-intensity exercise on brain function, cognition, and physical function in cognitively healthy, physically inactive older adults.
Purpose: To assess the feasibility of a home-based exercise intervention to improve memory in veterans with mild cognitive impairment.
Purpose: To gather information from people affected by frontotemporal degeneration (FTD), including people diagnosed with FTD, caregivers, friends, and family, and provide information about FTD study opportunities.
Purpose: To develop and test a telehealth intervention to address interpersonal difficulties between caregivers and persons with dementia in families with veterans.
Purpose: To test the effects of daily brain stimulation on levels of amyloid and tau in people with Alzheimer's disease.
Purpose: To evaluate the efficacy and safety of the investigational drug gantenerumab in people with early Alzheimer's disease.
Purpose: To learn more about biomarkers and their relationship to aging.
Purpose: To learn more about the genetic causes of movement disorders and dementias.
Purpose: To investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment.
Purpose: To test the effectiveness of self-managed health interventions to improve the mental and physical health of highly stressed dementia caregivers.
Purpose: To evaluate procedures that will help determine the impact of hearing aid interventions on older individuals with Alzheimer's disease and related dementias.
Purpose: To test high and regular doses of vitamin D for treating vitamin insufficiency in older adults with low vitamin D.
Purpose: To evaluate transcranial direct current stimulation for chronic pain management in people with early-stage Alzheimer's disease or a related dementia.
Purpose: To test an iPad application for measuring neurological functioning.
Purpose: To test the radioactive tracer 11C-ER176 in measuring inflammation in the brain of people with Alzheimer's disease.
Purpose: To determine how inflammation is related to other changes in the brain that occur in Alzheimer's disease.
Purpose: To test interventions designed to reduce stress and improve physical and emotional health in older adults who care for a family member with dementia.
Purpose: To determine the effects of dance movement and social engagement on quality of life in older adults with mild cognitive impairment or early Alzheimer's disease.
Purpose: To develop and evaluate an in-home supportive technology to help alleviate anxiety, burden, and loneliness in family caregivers of people with Alzheimer's disease, related dementias, or mild cognitive impairment.
Purpose: To develop and evaluate in-home assistive technology to alleviate anxiety, burden, and loneliness in caregivers of people with Alzheimer's disease and frontotemporal dementia.
Purpose: To test the effect of a telephone-based intervention on reducing the burdens of dementia-associated symptoms and behaviors.
Purpose: To test an online care planning tool designed to provide individualized information to better serve the diverse needs of caregivers and care recipients living with Alzheimer's disease or a related dementia.
Purpose: To examine the potential effects of long-term, computerized cognitive training on structural and functional brain networks in older adults with mild cognitive impairment.
Purpose: To test a tailored behavioral intervention for LGBT individuals with Alzheimer's disease or a related dementia and their caregivers.
Purpose: To test cognitive behavioral therapy for insomnia to improve the sleep of community-dwelling persons living with dementia and their caregivers.
Purpose: To test the effects of insulin delivered through the nose on memory in older adults.
Purpose: To compare two forms of diet and their effects on insulin resistance, weight, and brain chemicals related to Alzheimer's disease.
Purpose: To examine whether increasing social interaction through face-to-face web-based conversations could improve cognitive function in older adults who are socially isolated.
Purpose: To evaluate a program of activities to improve symptoms of disturbed sleep-wake cycles in people with dementia who live at home.
Purpose: To develop effective interventions that improve swallowing for people with Alzheimer's Disease at risk for pneumonia.
Purpose: To test the safety and effectiveness of oxytocin given by a spray into the nose, to decrease apathy and other behavioral symptoms in people with frontotemporal dementia.
Purpose: To assess eligibility for ongoing research, develop a registry for future trials, and gather biospecimens to carry out laboratory-based studies in adults with frontotemporal dementia, a motor neuron disorder, or related adult-onset neurodegenerative disorder.
Purpose: To examine whether a 12-month exercise intervention improves brain health in cognitively normal older adults.
Purpose: To evaluate the safety and tolerability of the study drug K0706 in people with dementia with Lewy bodies.
Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.
Purpose: To test whether lenalidomide reduces inflammation and improves cognition in people with amnestic mild cognitive impairment.
Purpose: To test leuprolide acetate (Eligard) in women with Alzheimer's disease taking a stable dose of donepezil (Aricept.)
Purpose: To evaluate the effect of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.
Purpose: To determine whether comprehensive lifestyle changes, such as diet and exercise, may slow, stop, or reverse the progression of early-stage Alzheimer's disease.
Purpose: To test an iPad app that delivers light therapy at 40 Hz, combined with cognitive therapy, to improve cognition in people with Alzheimer's.
Purpose: To test the effects of a tailored lighting system on sleep, mood, inflammation, and glucose tolerance in older adults with Alzheimer's disease or a related dementia and type 2 diabetes.
Purpose:: To test the long-term effect of a light treatment on cognition, sleep, and metabolism in people with MCI, mild Alzheimer's disease, or a related dementia.
Purpose: To test lithium as a treatment that may prevent or delay dementia in people with mild cognitive impairment.
Purpose: To look at disease progression in adults with early-onset Alzheimer's disease.
Purpose: To better understand how different types of biomarkers may relate to immune health and the aging process.
Purpose: To evaluate the safety and tolerability of Lu AF87908 in healthy participants and participants with Alzheimer's disease.
Purpose: To understand the factors that underlie changes in thinking and memory with increasing age and identify the best combination of tests for predicting cognitive decline.
Purpose: To test repetitive transcranial magnetic stimulation in adults with and without mild cognitive impairment.
Purpose:: To test the safety and efficacy of MW151 to treat cognitive disorders.
Purpose: To examine whether taking melatonin improves Alzheimer's disease biomarkers and cognitive function in older adults with and without mild cognitive impairment.
Purpose: To test the effects of a nicotine skin patch on memory performance in older adults with mild cognitive impairment (MCI).
Purpose: To study imaging differences between children of parents with and without late-onset Alzheimer's disease.
Purpose: To examine the impact of mind-body interventions on neurocognitive and emotional functioning in older adults.
Purpose: To adapt and examine a mind-body program, called Active Brains, to meet the needs of older adults with chronic pain and mild cognitive impairment.
Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.
Purpose: To test the effectiveness of mindfulness training to reduce social isolation and feelings of loneliness in older caregivers of family members with Alzheimer's disease or a related dementia.
Purpose: To assess telephone-based mindfulness training to alleviate caregiver burden for African American rural caregivers of people with moderate to severe dementia.
Purpose: To test a mobile application designed to monitor and support individuals with dementia-related agitation.
Purpose: To test a mobile-based web intervention designed to reduce dementia caregiver distress and improve overall well-being.
Purpose: To evaluate a cognitive retraining program in cognitively healthy older adults and adults with mild cognitive impairment.
Purpose: To test montelukast as a treatment for people with mild cognitive impairment and early Alzheimer's dementia.
Purpose: To investigate whether an anti-inflammatory diet tailored to a multicultural population can improve cognitive functioning.
Purpose: To examine the safety of single and multiple doses of the investigational drug NNI-362 in healthy older adults as a potential treatment for Alzheimer's disease.
Purpose: To document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy).
Purpose: To test whether near-infrared light stimulation can improve cognition in older adults with mild cognitive impairment.
Purpose:: To assess the effects of noninvasive brain stimulation on memory and language ability in people with amnestic mild cognitive impairment or the logopenic variant of primary progressive aphasia.
Purpose: To determine if neurofilament light chain can be used as an early biomarker for frontotemporal lobar degeneration.
Purpose: To test nicotinamide, a form of vitamin B3, as an early treatment for mild cognitive impairment or mild Alzheimer's disease.
Purpose: To test the effects of the supplement nicotinamide riboside on memory and brain blood flow in older adults with mild cognitive impairment.
Purpose:To test whether Horizant, a drug approved for treating restless legs syndrome (RLS), could reduce nighttime agitation and improve sleep in nursing home residents with Alzheimer's and RLS.
Purpose: To evaluate the effects of nilotinib in adults with dementia with Lewy bodies.
Purpose: To enroll adults with rapid eye movement sleep behavior disorder for the purpose of preparing for a clinical trial of neuroprotective treatments against synucleinopathies.
Purpose: To examine the Cognitive Stress Test in distinguishing between early-stage mild cognitive impairment and cognitively normal older adults.
Purpose: To develop new measures of cognition and everyday function for use in preclinical Alzheimer's disease trials.
Purpose:To better understand the experience of older adults living alone with mild cognitive impairment or Alzheimer's disease.
Purpose: To evaluate the effect of icosapent ethyl in veterans at increased risk of Alzheimer's.
Purpose: To evaluate an interactive, online workshop designed to support isolated dementia caregivers in rural areas and reduce caregiver stress and depression.
Purpose: To test the effectiveness of GamePlan4Care (GP4C), an evidence-based, online system designed to provide accessible, tailored caregiver support and skills training.
Purpose: To test the effectiveness of an online training program for family caregivers of someone with mid-stage Alzheimer's disease.
Purpose: To test the feasibility of conducting a study using online yoga to reduce chronic pain for people with Alzheimer's disease.
Purpose: To evaluate a program that provides daily mouth care for assisted living residents with dementia.
Purpose:To test a radioactive tracer for showing inflammation in the brain on positron emission tomography scans of people with progressive neurological disorders.
Purpose: To study the safety of PTI-125 medication and its effect on biomarkers, cognition, and neuropsychiatric symptoms in older adults with Alzheimer's disease.
Purpose: To evaluate the benefits of an early palliative-care intervention for people with cognitive impairment and their family caregivers.
Purpose: To determine whether partnered rhythmic rehabilitation, which targets fitness, cognition, mobility, and social engagement, may prevent future functional problems in people with mild cognitive impairment due to Alzheimer's disease.
Purpose: To assess the effects of exercise on middle-aged cognitively normal adults who have a family history of Alzheimer's disease.
Purpose: To determine whether treatment with the drug pimavanserin decreases the psychological symptoms of dementia in older adults.
Purpose: To determine the safety and tolerability of Posiphen in people with early Alzheimer's or early Parkinson's disease.
Purpose: To evaluate Posiphen® in older adults with early-stage Alzheimer’s disease.
Purpose: To test whether the practice of positive emotions can increase caregiver well-being and decrease the stress of caregiver burden.
Purpose: To evaluate a mindfulness-based intervention for caregivers of people with dementia.
Purpose: To test if the medication prazosin to see if it affects levels of tau and beta-amyloid in the brain of persons with mild TBI.
Purpose: To examine how different types of training activities affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function.
Purpose: To compare Problem Adaptation Therapy to Supportive Therapy for improving cognitive, affective and functioning outcomes in people with mild cognitive impairment.
Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.
Purpose: To determine if the Social Engage behavioral intervention can effectively increase social connection for dementia caregivers.
Purpose: To test whether a wearable device can decrease sedentary behavior, or inactivity, in older Latinos and whether increased activity improves cognitive function.
Purpose: To remediate and delay progression of word-finding problems in people with primary progressive aphasia.
Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.
Purpose: To connect people interested in health research with studies that match their interests.
Purpose: To develop and evaluate biomarkers using a non-invasive imaging test in people with mild cognitive impairment (MCI) or Alzheimer's.
Purpose: To test the effectiveness of a retinal imaging system to measure changes in the eye to diagnose cognitive disorders and dementia.
Purpose: To establish a bank of blood, cerebrospinal fluid, imaging, and clinical data to be used in Alzheimer's disease research.
Purpose: To examine the role of a subset of receptors in the brain, called the nicotinic system, in memory and thinking and healthy aging.
Purpose: To test the safety and tolerability of S-equol, a compound that acts like estrogen in the body, and its effects on cognition in adults with Alzheimer's disease.
Purpose: To adapt and test an advance care planning intervention, Sharing Patient's Illness Representations to Increase Trust (SPIRIT), in older adults with mild dementia and their surrogates to promote end-of-life care discussions.
Purpose: To evaluate the efficacy of multi-odorant enrichment on cognitive skills, olfactory function, and quality of life.
Purpose: To adapt and test the Tele-Savvy online caregiver training program to address the unique challenges of caregiving for a person with primary progressive aphasia.
Purpose: To test the design of a caregiver training program developed to address the unique challenges facing lesbian, gay, bisexual, and transgender (LGBT) caregivers of a person living with dementia.
Purpose: To develop a sleep intervention program for people with Alzheimer's disease and their caregivers, who both experience sleep difficulties.
Purpose: To test the effects of cognitive behavioral training for insomnia (CBT-I) in older adults with symptoms of insomnia.
Purpose: To evaluate the use of SmartPrompt, a smartphone-based electronic reminder aid that is designed to help older adults with dementia perform daily tasks.
Purpose: To evaluate two evidence-based speech language therapy treatments for adults with mild primary progressive aphasia.
Purpose: To learn about the effects of weak electrical stimulation on brain functioning in people with mild cognitive impairment.
Purpose: To evaluate the efficacy of a novel cognitive training approach in older adults using simulated games.
Purpose: To test the effects of strawberry powder on cognition and mobility in cognitively normal obese older adults.
Purpose: To determine the effect of dementia caregiver preferences on stress management interventions.
Purpose: To test whether the Wish Outcome Obstacle Plan lowers the stress of partners and spouses of people with early-stage dementia.
Purpose: To evaluate a blood test for detecting amyloid-beta, a protein involved in Alzheimer's disease.
Purpose: To better understand the role of the immune response, including inflammation, in Parkinson's disease (PD) and Alzheimer's disease (AD).
Purpose: To enroll older adults in an online study tracking healthy brain aging.
Purpose: To test the effectiveness of transcranial magnetic stimulation combined with language therapy to improve verbal communication in people with Alzheimers disease.
Purpose: To determine the effects of a cognitively enhanced tai ji quan exercise intervention in improving cognitive function and dual-task ability in older adults with mild cognitive impairment.
Purpose: To investigate the effects of transcranial direct current stimulation during short-term memory therapy in people with primary progressive aphasia and related neurodegenerative conditions.
Purpose: To study how the protein tau is made, transported, and cleared in healthy younger and older adults and in older adults with Alzheimer's disease.
Purpose: To use positron emission tomography imaging with a new radioactive tracer 18F-MK-6240 to understand the cognitive and behavioral outcomes of tau deposition in specific brain regions in cognitively normal and mildly cognitively impaired older adults.
Purpose: To test a radioactive tracer, 18F-AV-1451, for showing tau protein patterns on brain scans of people with primary progressive aphasia.
Purpose: To test a radioactive tracer, 18F-APN-1607, for showing tau protein patterns on brain scans of people with Alzheimer's disease.
Purpose: To test a telephone-based behavioral intervention designed to reduce anxiety and associated psychological distress in dementia caregivers.
Purpose: To determine if the blood-pressure medication telmisartan might help prevent Alzheimer's disease in African Americans.
Purpose: To correlate microbiome data with information about Alzheimer's disease.
Purpose: To study the use of a videoconference-based system known as Support via Technology: Living and Learning with Advancing Alzheimer's Disease and Related Dementias to provide education and support to family caregivers, as well as the person with dementia.
Purpose: To learn how certain diets (ketogenic and Therapeutic Lifestyle Changes) affect cognition in adults with Alzheimer's disease.
Purpose: To test the effects of a behavioral intervention known as strategy training on the progression of disability in older adults with mild cognitive impairment.
Purpose: To investigate the effect of transcranial alternating current stimulation on sleep and cognitive performance in older adults.
Purpose: To investigate the effects of transcranial direct current stimulation (tDCS) and language therapy on adults with PPA.
Purpose: To study the effects of transcranial direct current stimulation during language therapy in people with primary progressive aphasia.
Purpose: To test the effects of noninvasive stimulation on the brain to determine whether it can reset disconnections to stabilize or improve memory and cognitive function.
Purpose: To explore the use of Transcranial Magnetic Stimulation (TMS) integrated with Functional Magnetic Resonance Imaging (fMRI) for diagnosing preclinical dementia.
Purpose: To investigate the effects of transcranial magnetic stimulation in older veterans with mild memory loss and apathy.
Purpose: To test a noninvasive brain stimulation therapy to improve cognition, including memory, in older adults and people with amnestic mild cognitive impairment due to Alzheimer's disease.
Purpose: To test whether repetitive transcranial magnetic stimulation, an approved treatment for depression, can effectively improve cognitive function and recovery from stressful situations.
Purpose: To investigate the effects of transcutaneous vagal nerve stimulation on cognitive performance and memory in older adults with mild cognitive impairment.
Purpose: To develop and test a mobile health application, the CARE-well App, that will provide resources to support informal dementia caregivers.
Purpose: To help people interested in joining a clinical trial find studies related to Alzheimer's disease and related dementias.
Purpose: To develop a trial-ready cohort for Alzheimer's disease prevention clinical trials.
Purpose: To identify and distinguish two different types of progressive apraxia of speech (PAOS) through clinical imaging and testing in adults with PAOS.
Purpose: To test the effects of lifestyle changes on memory loss and thinking in older Americans who are at risk for memory loss.
Purpose: To identify brain changes related to Alzheimer's disease in older adults with and without cognitive impairment.
Purpose: To test the efficacy of the anti-viral drug valacyclovir in treating adults with mild Alzheimer's disease who also test positive for herpes simplex virus-1 (HSV-1) or HSV-2.
Purpose: To test the combined effects of visual cognitive training games and aerobic exercise to improve cognition in older adults with mild cognitive decline and who are at-risk for developing Alzheimer's disease.
Purpose: To test whether a virtual reality game, called Labyrinth, improves long-term memory in older adults and people with mild cognitive impairment.
Purpose: To understand how behavioral variant frontotemporal dementia (bvFTD) affects people's day-to-day lives, how people think about themselves, and what challenges they face.
Purpose: To evaluate whether weighted blankets can reduce agitation in hospitalized patients with dementia.