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Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease


The purpose of this study is to determine the eligibility of individuals for Alzheimer's disease clinical trials.

Minimum Age Maximum Age Gender Healthy Volunteers
45 Years N/A Both Accepts Healthy Volunteers
July 2009

++Age 45 or older++History of progressive memory impairment++Caregiver who is willing to accompany the subject to the National Institutes of Health Clinical Center

++Diagnosis of a non-Alzheimer's dementia, including frontotemporal dementia, normal pressure hydrocephalus, Lewy body dementia, Parkinson's disease dementia, Huntington's disease, or vascular dementia ++Pregnant women; women of childbearing potential will be screened by history for the possibility of pregnancy and undergo a urine pregnancy test ++Any medical contraindication to the procedures performed in the study or any current severe medical or psychiatric illness other than Alzheimer's++Behavioral symptoms that preclude the gathering of data for the study or advanced disease such that volunteers cannot provide assent

Individuals who demonstrate symptoms of Alzheimer's disease, such as progressive memory loss, may be eligible to participate in National Institutes of Health research studies. However, other physical and psychological conditions may produce symptoms similar to those of Alzheimer's. To determine whether a patient meets the eligibility criteria to participate in a research study, researchers must perform a series of diagnostic tests and procedures. These evaluations are designed to evaluate a participant's general medical condition (using, for example, blood tests and neurological exams) and to confirm a diagnosis or rule out an individual for consideration. 

Required tests and procedures for various research studies may include the following: medical history and physical examination, including a psychiatric evaluation; neuropsychological tests to test memory, mood, concentration, and thought processes; blood and urine tests; and imaging studies (X-rays, magnetic resonance imaging, computerized tomography, positron emission tomography. After all eligibility assessments are complete, participants may be offered participation in one or more research protocols.

Name City State Zip Status Primary Contact
National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda Maryland 20892

National Institute of Mental Health (NIMH)

Name Role Affiliation
William C. Kreisl, MD Principal Investigator National Institute of Mental Health (NIMH)

Name Phone Email
Meghan S. McGwier 301-451-2038


Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease