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Risk Evaluation and Education for Alzheimer's Disease (REVEAL) IV

  • Active, not recruiting

This study will examine the impact of receiving a genetic risk assessment for Alzheimer's disease among individuals with mild cognitive impairment (MCI).

Minimum Age Maximum Age Gender Healthy Volunteers
55 Years 90 Years Both No
January 2010
June 2013
360

++Amnestic mild cognitive impairment (as defined by the Petersen criteria)++Fluent in English++Close friend, relative, or spouse willing to attend each study visit with the participant and complete surveys and interviews

++Current untreated anxiety or depression++Diagnosis of dementia or Alzheimer's disease

Apolipoprotein E (APOE) is a gene that can provide information about a person's chances of developing Alzheimer's disease. Some people with a diagnosis of MCI are curious to learn more about their chance of developing Alzheimer's. We will examine the psychological and behavioral impact of learning genetic information pertaining to the risk of progressing from MCI to Alzheimer's within 3 years.

This study requires participation in an education session, knowledge and attitudinal surveys, and tests to assess memory and thinking skills. Participants with MCI will have their blood drawn for genetic testing and be randomized to one of two groups. Those in the intervention arm will receive a 3-year risk estimate for the chance of progressing to dementia of the Alzheimer's type with the APOE gene test result. Those in the comparison arm will receive a 3-year risk estimate for the chance of progressing to dementia of the Alzheimer's type without the APOE gene test result. The latter group will have the opportunity to learn their own APOE gene test result at the end of the study.

Participants and their study partners will be followed for 6 months following disclosure of results, with one additional clinic visit and one additional phone interview.

Name City State Zip Status Primary Contact
Washington District of Columbia 20060

Ann Arbor Michigan 48109

Philadelphia Pennsylvania 19104

Brigham and Women's Hospital

  • National Human Genome Research Institute (NHGRI) - NIH
  • University of Michigan - Other
  • University of Pennsylvania - Other
  • Howard University - Other

Name Role Affiliation
Robert C. Green, MD, MPH Principal Investigator Brigham and Women's Hospital/Harvard Medical School

Name Phone Extension Email
Leo B. Waterston 617-264-5879 lwaterston@genetics.med.harvard.edu

Risk Evaluation and Education for Alzheimer`s Disease (REVEAL) IV