Alzheimer's Disease Education and Referral Center

Search for Clinical Trials

Your Search Identified 122 Trial(s):

  • 1. 4 Repeat Tauopathy Neuroimaging Initiative

    Purpose: To identify the best methods for tracking and analyzing progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) over time.

  • 2. ABT-957 in Subjects with Mild to Moderate Alzheimer's Taking Acetylcholinesterase Inhibitors

    Purpose: To evaluate the safety, tolerability, and pharmacokinetics of ABT-957 in people with mild to moderate Alzheimer's disease.

  • 3. AC-1204 for Mild to Moderate Alzheimer's Disease

    Purpose: To evaluate the effects of AC-1204 on cognition, activities of daily living, quality of life, pharmacokinetic measures, and safety in people with mild to moderate Alzheimer's disease.

  • 4. Aerobic & Cognitive Exercise Study (ACES)

    Purpose: To clarify the benefits to brain health and thinking processes that result from different forms of exercise.

  • 5. Albumin and Immunoglobulin in Alzheimer's Disease

    Purpose: To evaluate changes in cognition, functioning, and behavior in people with mild to moderate Alzheimer's disease who undergo an experimental infusion treatment.

  • 6. Allopregnanolone for Mild Cognitive Impairment or Mild Alzheimer's Disease

    Purpose: To evaluate the safety and tolerability of allopregnanolone, a naturally occurring brain steroid, in people with mild cognitive impairment or mild Alzheimer's disease.

  • 7. Alzheimer's Biomarkers in African Americans

    Purpose: To determine the influence of Alzheimer's disease and vascular disease on memory and aging in African Americans through biomarkers.

  • 8. Alzheimer's Caregiver Coping: Mental and Physical Health

    Purpose: To compare two intervention strategies for reducing emotional and cardiovascular disease risk in Alzheimer's caregivers.

  • 9. Alzheimer's Disease Genetics Study

    Purpose: To identify the genes that are responsible for causing Alzheimer's disease by collecting genetic material from families with multiple members diagnosed with Alzheimer's disease.

  • 10. Alzheimer's Disease Multiple Intervention Trial

    Purpose: To improve functioning among older adults with Alzheimer's disease by comparing a control group receiving best practices primary care with an intervention group receiving best practice primary care plus a home-based occupational therapy intervention.

  • 11. Alzheimer's Prevention Registry

    Purpose: To enroll individuals who are interested in learning about and possibly participating in Alzheimer's prevention clinical studies and trials in a national registry.

  • 12. Alzheimer's Prevention Through Exercise

    Purpose: To learn about the possible benefits of aerobic exercise for individuals at risk of developing Alzheimer's disease.

  • 13. Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4)

    Purpose: To test whether an anti-amyloid investigational drug, solanezumab, can slow memory and cognitive decline in older individuals who do not yet show symptoms of Alzheimer's disease cognitive impairment or dementia.

  • 14. Arterial Spin Labeling (ASL) MRI for Cognitive Decline

    Purpose: To determine the value of arterial spin labeling magnetic resonance imaging, a measure of blood flow to the brain, in finding the cause of cognitive decline in people with mild cognitive impairment.

  • 15. AZD0530 in Mild Alzheimer's Disease (Connect Study)

    Purpose: To determine the safety and efficacy of the experimental drug AZD0530 in older adults with mild Alzheimer's disease.

  • 16. AZD3293 in Early Alzheimer's Disease (AMARANTH)

    Purpose: To assess the efficacy and safety of AZD3293 as a possible treatment for early Alzheimer´s disease.

  • 17. Azeliragon (TTP488) for Mild Alzheimer's Disease (STEADFAST)

    Purpose: To evaluate the efficacy and safety of the experimental drug azeliragon in people with mild Alzheimer's disease.

  • 18. BAN2401 for Early Alzheimer's Disease

    Purpose: To determine the effectiveness of the experimental drug BAN2401 as a possible treatment for people with mild cognitive impairment or mild Alzheimer's disease.

  • 19. Behavioral Interventions to Prevent or Delay Dementia

    Purpose: To compare the effectiveness of different combinations of five behavioral interventions in people with amnestic mild cognitive impairment.

  • 20. Benfotiamine in Alzheimer's Disease

    Purpose: To determine whether treatment with benfotiamine, a dietary supplement, minimizes cognitive decline in older adults with amnestic mild cognitive impairment or mild Alzheimer's disease.

  • 21. Bisnorcymserine in Healthy Adult Volunteers

    Purpose: To test the safety and action of the drug bisnorcymserine in healthy older volunteers.

  • 22. Brain Alterations and Cognitive Impairment in Older Adults with Heart Failure

    Purpose: To study the relationship between brain MRI results and cognitive impairment in older adults with heart failure.

  • 23. Brain Health Registry

    Purpose: To enroll people interested in participating in brain health research in an ongoing online registry.

  • 24. Brexpiprazole for Agitation in Alzheimer's Dementia

    Purpose: To assess the efficacy of the experimental drug brexpiprazole in people with agitation due to Alzheimer's dementia.

  • 25. Candesartan vs. Lisinopril Effects on the Brain (CALIBREX)

    Purpose: To compare the effects of two hypertension medications on the brains of people with high blood pressure and impaired executive functioning.

  • 26. Care Ecosystem: Navigating Patients and Families Through Stages of Care

    Purpose: To evaluate a care model for people with dementia and their family caregivers.

  • 27. Caregiver Health-e Brain Study

    Purpose: To assess the cognitive health of caregivers of people with Alzheimer's disease or other dementias.

  • 28. Carvedilol in Alzheimer's Disease

    Purpose: To determine whether carvedilol treatment is associated with improvement in Alzheimer's disease compared to a placebo.

  • 29. Cataract Removal and Alzheimer's Disease

    Purpose: To determine if cataract removal will improve the quality of life, vision, and cognition in people with Alzheimer's disease.

  • 30. Characterizing Cognitive Decline in Late-Life Depression (ADNI-D)

    Purpose: To characterize the biological mechanisms contributing to cognitive impairment and decline in older adults with depression.

  • 31. Cholinesterase Inhibitor Discontinuation

    Purpose: To determine if stopping certain medications for Alzheimer's disease will cause worsened cognition, functioning, or behavior in veterans with advanced dementia.

  • 32. Clinical Evaluation of Florbetapir F 18 (18F-AV-45)

    Purpose: To standardize imaging studies using florbetapir F 18 PET to provide information on amyloid burden.

  • 33. Coconut Oil for Alzheimer's Disease

    Purpose: To determine the efficacy of coconut oil as a possible treatment for mild to moderate Alzheimer's disease.

  • 34. Cognitive and Aerobic Resilience for the Brain (CARB)

    Purpose: To test the impact of cognitive and/or exercise training on cognition in older adults with mild cognitive impairment.

  • 35. Cognitive Benefits of Aerobic Exercise Across the Age Span

    Purpose: To test the hypothesis that aerobic exercise leads to improved cognitive function.

  • 36. Cognitive Training and Practice Effects in MCI

    Purpose: To test the effectiveness of a computerized cognitive (thinking) training program in people with mild cognitive impairment.

  • 37. Cognitive Video Game Performance in Healthy Older Adults

    Purpose: To evaluate the difference in learning and performance measures associated with using a video game in healthy older adults.

  • 38. CPC-201 to Treat Alzheimer's Dementia

    Purpose: To test the experimental drug CPC-201 as a treatment for Alzheimer's dementia.

  • 39. Crenezumab for Mild to Moderate Alzheimer Disease

    Purpose: To evaluate the safety and tolerability of crenezumab in older adults with mild to moderate Alzheimer's disease.

  • 40. Curcumin and Yoga Therapy for Mild Cognitive Impairment

    Purpose: To test the clinical benefits of curcumin, a compound isolated from turmeric root, and a yoga-based physical exercise program in individuals with early memory problems.

  • 41. Cycling Exercise for Treating Alzheimer's Disease

    Purpose: To investigate the effects of a cycling exercise program on cognition and hippocampal volume in older adults with Alzheimer's disease.

  • 42. Dominantly Inherited Alzheimer Network (DIAN)

    Purpose: To identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.

  • 43. Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia (DIAN TU)

    Purpose: To assess the safety, tolerability, and biomarker efficacy of gantenerumab and solanezumab in individuals who have a genetic mutation for autosomal-dominant Alzheimer's disease.

  • 44. Down Syndrome Memantine Follow-up Study

    Purpose: To determine if the drug memantine can improve learning and memory in adolescents and young adults with Down syndrome.

  • 45. E2609 for Mild Cognitive Impairment Due to Alzheimer's Disease

    Purpose: To evaluate the safety and efficacy of the experimental drug E2609 in people with mild cognitive impairment or mild dementia due to Alzheimer's disease.

  • 46. Early Detection and Prevention of Mild Cognitive Impairment Due to Cerebrovascular Disease

    Purpose: To study vascular risk factors that cause memory and thinking problems and ways to control these risk factors.

  • 47. Educational Video to Improve Nursing Home Care in End-Stage Dementia

    Purpose: To determine the impact of an educational video for professional caregivers on the care of nursing homes residents with advanced dementia compared with the usual care.

  • 48. EEG Guidance of Anesthesia to Alleviate Geriatric Syndromes (ENGAGES)

    Purpose: To determine whether, compared with usual anesthetic care, an EEG-guided anesthesia protocol can prevent delirium after surgery.

  • 49. Effect of NeuroAD on Cognitive Function in Alzheimer's Disease

    Purpose: To test the effect of NeuroAD, a noninvasive device that delivers magnetic stimulation to the brain, on cognition in people with Alzheimer's disease.

  • 50. Effects of Aging and Estrogen on Memory and Cognition

    Purpose: To examine the impact of aging on functional changes induced by estrogen in parts of the brain associated with memory

  • 51. Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

    Purpose: To evaluate the effects of surgical anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery.

  • 52. Effects of Atomoxetine in Mild Cognitive Impairment

    Purpose: To find out if atomoxetine causes a change in the biomarkers (substances that may indicate the presence of a disease) in the cerebrospinal fluid of people diagnosed with mild cognitive impairment.

  • 53. Effects of Brain Beta-Amyloid on Postoperative Cognition

    Purpose: To determine if the presence of beta-amyloid plaques in the brains of non-demented patients before hip or knee replacement surgery predicts cognitive decline after surgery.

  • 54. Effects of Donepezil Measured by Functional MRI

    Purpose: To examine the sensitivity of functional MRI to detect brain changes in healthy older adults at genetic risk for Alzheimer's disease who take donepezil (Aricept).

  • 55. Escitalopram's Effects on Amyloid Beta

    Purpose: To test the effects of the antidepressant escitalopram on levels of amyloid beta in the cerebrospinal fluid of cognitively normal older adults.

  • 56. Evaluation of Tracers for Positron Emission Tomography (PET) Imaging of Tau

    Purpose: To obtain basic information about three PET imaging tracers developed to detect tau pathology in the brain.

  • 57. EVP-6124 for Treating Alzheimer's Disease

    Purpose: To evaluate the safety and efficacy of EVP-6124 as a potential treatment for mild to moderate Alzheimer's disease.

  • 58. Exendin-4 in Alzheimer's Disease

    Purpose: To determine the safety and effectiveness of twice daily administration of Exendin-4 as a treatment for early-stage Alzheimer's disease or mild cognitive impairment.

  • 59. Exercise and Cognitive Training to Improve Cognition in People with Heart Failure

    Purpose: To test the effects on cognition of a combined exercise and cognitive training program in people with heart failure.

  • 60. Exercise, Age-Related Memory Decline, and Hippocampal Function

    Purpose: To test the hypothesis that aerobic exercise leads to increased blood volume in the brain, specifically in the dentate gyrus of the hippocampus.

  • 61. Fitness, Aging, and Stress Study for Dementia Caregivers

    Purpose: To determine whether an aerobic exercise program will alter markers of immune cell aging, improve blood pressure, and decrease psychological distress in caregivers of people with Alzheimer's disease.

  • 62. FRM-0334 for Frontotemporal Dementia with a Granulin Mutation

    Purpose: To investigate the safety, tolerability, and pharmacodynamics of the experimental drug FRM-0334 in people with early to moderate frontotemporal dementia with a granulin mutation.

  • 63. Gantenerumab for Mild Alzheimer Disease

    Purpose: To evaluate the efficacy and safety of the experimental drug gantenerumab as a possible treatment for people with mild Alzheimer disease.

  • 64. GC021109 for Mild to Moderate Alzheimer's Disease

    Purpose: To test the safety and pharmacokinetics of the experimental drug GC021109 in people with mild to moderate Alzheimer's disease. 

  • 65. Gemfibrozil in Predementia Alzheimer's Disease

    Purpose: To assess the drug gemfibrozil for the prevention of Alzheimer's disease.

  • 66. Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (GESTALT)

    Purpose: To learn more about biomarkers and their relationship to aging.

  • 67. Hispanic Caregiver Intervention Effectiveness Study

    Purpose: To compare two dementia caregiver interventions to determine which is most effective for Hispanic caregivers in New York City.

  • 68. Home Exercise for Seniors with Dementia and Their Caregivers

    Purpose: To determine the feasibility of an exercise program for older adults with dementia living at home and their caregivers.

  • 69. Home-based Dementia Care Coordination for Medicare-Medicaid Recipients

    Purpose: To implement and evaluate a home-based dementia care coordination program called MIND at Home-Plus.

  • 70. Home-Delivered Intervention for Depressed, Cognitively Impaired Elders

    Purpose: To test the efficacy of Problem Adaptation Therapy (PATH), a home-delivered psychosocial intervention for elders with major depression, memory problems, and disability.

  • 71. Human Brain Antioxidants During Oxidative Stress

    Purpose: To evaluate the level of two antioxidants in the brain as humans with and without Alzheimer's disease get older.

  • 72. Imaging of Cognition, Learning, and Memory in Aging

    Purpose: To study how the brain functions when it performs explicit memory tasks and how this changes as a function of aging.

  • 73. Improving Dementia Caregiver Sleep and the Effect on Heart Disease Biomarkers

    Purpose: To determine whether a combined intervention of a nighttime home monitoring system and cognitive-behavioral therapy for insomnia is effective in improving sleep in dementia caregivers who arise at night.

  • 74. Indiana University Dementia Screening Trial

    Purpose: To assess the harms and benefits of screening for dementia, compared to no screening for dementia, among older adults in a primary care setting.

  • 75. Influence of Fitness on Brain and Cognition

    Purpose: To examine the effect of aerobic fitness training on older adults' cognition, brain structure, and brain function.

  • 76. Language in Primary Progressive Aphasia

    Purpose: To further define the neurological and linguistic deterioration in primary progressive aphasia.

  • 77. Levetiracetam for Alzheimer's Disease-Associated Epileptiform Activity

    Purpose: To test the use of levetiracetam, an anticonsulvant, to control seizures in people with Alzheimer's disease.

  • 78. Lidocaine for Neuroprotection During Cardiac Surgery

    Purpose: To see if the drug lidocaine can prevent cognitive decline after heart surgery.

  • 79. Life-Enhancing Activities for Family Caregivers (LEAF)

    Purpose: To evaluate the effect of an intervention for caregivers of people with dementia to improve their emotional well-being.

  • 80. Longitudinal Evaluation of Familial Frontotemporal Dementia (LEFFTDS)

    Purpose: To learn about thinking and behavior in families in which one or more relatives has a genetic mutation associated with frontotemporal dementia.

  • 81. Lu AE58054 in People with Mild to Moderate Alzheimer's Disease Taking Donepezil

    Purpose: To test the drug Lu AE58054 as an add-on therapy to donepezil for people with mild to moderate Alzheimer's disease.

  • 82. Magnesium L-Threonate to Enhance Learning and Memory in People with Dementia

    Purpose: To study the effects on memory of taking a dietary supplement, magnesium L-threonate, in people with mild to moderate dementia and a magnesium deficiency.

  • 83. MEDI1814 for Mild to Moderate Alzheimer's Disease

    Purpose: To assess the safety and efficacy of the drug MEDI1814 in people with mild to moderate Alzheimer's disease.

  • 84. Memory & Exercise Training in Older Adults with Subjective Memory Complaints

    Purpose: To assess the cognitive impact of a program of memory training and aerobic exercise in people with subjective memory complaints.

  • 85. Memory and Thinking Problems in Older Adults After Surgery

    Purpose: To examine if and how brain scans can predict decline in memory and executive functioning in older adults after total knee replacement surgery.

  • 86. Memory Consolidation in Obstructive Sleep Apnea

    Purpose: To test the use of continuous positive airway pressure (CPAP) to reverse some or all memory deficits in people with obstructive sleep apnea.

  • 87. Metabolic Cerebral Imaging in Incipient Dementia (MCI-ID)

    Purpose: To determine whether positron emission tomography (PET) scanning can help distinguish patients with early Alzheimer's changes in their brains from those having other causes of cognitive impairment more accurately than current clinical practices.

  • 88. Mild Cognitive Impairment in Breast Cancer

    Purpose: To study how women undergoing breast cancer treatment may develop brain changes related to the development of mild cognitive impairment.

  • 89. MIND-S: Care Coordination for Community-living People with Dementia

    Purpose: To evaluate a home-based dementia care intervention for people with dementia and their family caregivers.

  • 90. MindCrowd

    Purpose: To study how genetics influences memory by analyzing adults' performance on a web-based memory test.

  • 91. MK-7622 in People with Alzheimer's Disease Taking Donepezil

    Purpose: To test the efficacy and safety of MK-7622 as an add-on therapy to donepezil in people with mild to moderate Alzheimer's disease.

  • 92. MK-8931 for Amnestic Mild Cognitive Impairment (APECS)

    Purpose: To assess MK-8931 as a possible treatment for amnestic mild cognitive impairment due to Alzheimer's disease.

  • 93. MK-8931 for Mild to Moderate Alzheimer's Disease (EPOCH Study)

    Purpose: To assess the efficacy and safety of MK-8931 as a possible treatment for Alzheimer's disease.

  • 94. Natural History of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

    Purpose: To characterize the natural history of disease in people who carry a repeat expansion in the C9ORF72 gene, which causes amyotrophic lateral sclerosis and frontotemporal dementia.

  • 95. NOBLE: T-817MA for Mild to Moderate Alzheimer's Disease

    Purpose: To evaluate the efficacy of the experimental drug T-817MA as a potential treatment for people with mild to moderate Alzheimer's disease.

  • 96. Olfactory Deficits and Donepezil Treatment in Cognitively Impaired Older Adults

    Purpose: To determine if a worsened sense of smell can identify older people who might benefit from treatment with the Alzheimer's drug donepezil.

  • 97. Omega 3 Polyunsaturated Fatty Acid for Vascular Cognitive Aging

    Purpose: To determine whether taking an omega 3 polyunsaturated fatty acid can promote brain health in cognitively normal older adults at risk for dementia.

  • 98. PET Imaging with 18F-AV-1451

    Purpose: To evaluate the characteristics of the brain imaging agent 18F-AV-1451 in cognitively healthy volunteers and in people with mild cognitive impairment or Alzheimer's disease.

  • 99. PET Imaging with [18F]XTRA

    Purpose: To test the ability of the imaging agent [18F]XTRA to detect early brain changes in neurodegenerative diseases such as Alzheimer's.

  • 100. PF-05212377 for People with Alzheimer's Disease and Neuropsychiatric Symptoms

    Purpose: To evaluate safety and efficacy of the experimental drug PF-05212377 in people with mild to moderate Alzheimer's disease and neuropsychiatric symptoms who take donepezil.

  • 101. Pharmacological Management of Delirium (PMD)

    Purpose: To develop and test the feasibility of using a specific pharmacological protocol to reduce delirium among older adults in the intensive care unit.

  • 102. Physical Activity Levels and Brain Structure in Mild Cognitive Impairment

    Purpose: To examine the relationship between physical activity levels, brain structure, and memory function in adults with mild cognitive impairment (MCI).

  • 103. Pomegranate Juice and Memory

    Purpose: To determine if drinking pomegranate juice benefits cognitive abilities in middle-aged and older adults without dementia.

  • 104. Prediction of Mild Cognitive Impairment and Pioglitazone to Delay Its Onset (TOMMORROW)

    Purpose: To develop a biomarker that predicts the risk of mild cognitive impairment due to Alzheimer's disease and to test the drug pioglitazone to delay the onset of MCI.

  • 105. Promoting Adaptive Neuroplasticity in Mild Cognitive Impairment

    Purpose: To test the effects of transcranial direct current stimulation on memory in people with mild cognitive impairment.

  • 106. Rasagiline in Alzheimer's Disease

    Purpose: To evaluate the effect of the drug rasagiline on brain metabolism in people with mild to moderate Alzheimer's disease.

  • 107. Reducing Agitation in People with Dementia

    Purpose: To test a nonpharmacologic intervention, the Tailored Activity Program, for reducing agitation in people with dementia.

  • 108. Reducing Disabilities in Alzheimer's Disease Through Community-Based Services

    Purpose: To test implementation of a program to help older adults with dementia remain physically and mentally healthy through Area Agencies on Aging.

  • 109. Reliability of the Human Brain Connectome

    Purpose: To use magnetic resonance imaging to investigate brain function and connections in healthy adults.

  • 110. Repetitive Transcranial Magnetic Stimulation for Apathy in Alzheimer's Dementia

    Purpose: To determine if repetitive transcranial magnetic stimulation (rTMS) can effectively treat apathy in people with Alzheimer's dementia.

  • 111. Riluzole for Mild Alzheimer's Disease

    Purpose: To test the safety and effectiveness of the drug riluzole for treating mild Alzheimer's disease.

  • 112. Screening and Evaluation of Patients with Signs and Symptoms of Alzheimer's Disease

    Purpose: To determine whether a person meets the eligibility criteria to participate in an Alzheimer's disease research study.

  • 113. Sleep-Disordered Breathing and Alzheimer's Disease Prevention (SNAP)

    Purpose: To examine the relationship between sleep-disordered breathing and Alzheimer's disease in cognitive normal older adults.

  • 114. Strawberry Supplementation in Older Adults

    Purpose: To assess the effects of taking strawberry supplements on cognition and mobility in older adults.

  • 115. SUVN-G3031 Safety, Tolerability, and Pharmacokinetics

    Purpose: To investigate the safety, tolerability and pharmacokinetics of SUVN-G3031 in healthy subjects.

  • 116. Tau Imaging in Young-Onset Dementia

    Purpose: To compare regional brain uptake of [18F]T807, a brain imaging agent, in younger adults with dementia.

  • 117. Tele-Savvy, a Distance Dementia Caregiver Education Program

    Purpose: To test the web-based delivery of an in-person program that educates informal caregivers of people with Alzheimer's disease.

  • 118. Transcranial Magnetic Stimulation to Treat Alzheimer's

    Purpose: To test transcranial magnetic stimulation as a treatment for Alzheimer's disease.

  • 119. Treatment of Psychosis and Agitation in Alzheimer's Disease

    Purpose: To test lithium as a treatment for psychosis and agitation in older adults with Alzheimer's disease.

  • 120. VA Cultivating Access to Resources, Education, and Skills for Dementia Caregivers (VA CARES)

    Purpose: To study the effects of an education and skill-building intervention on family caregivers of veterans with dementia.

  • 121. Venlafaxine for Depression in Alzheimer's Disease

    Purpose: To test the use of venlafaxine to treat depression in people with Alzheimer's disease.

  • 122. Walking Intervention, Cognitive Remediation, and Mild Cognitive Impairment

    Purpose: To determine the effects of cognitive remediation training and walking on cognition and gait in the elderly.

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