Reliability of the Human Brain Connectome
Researchers will use magnetic resonance imaging (MRI) to investigate brain function and connections in healthy adults. This might help people with brain diseases in the future.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|18 Years||85 Years||Both||Yes|
No specific criteria given.
- Pregnant or breast feeding
- Use of psychoactive medication in the past 2 weeks or medication that can affect brain function, including fluoxetine, meperidine, tricyclic antidpressants, selective serotonin reuptake inhibitors, or serotonin norepinephrine reuptake inhibitors
- Current or past diagnosis of a psychiatric or severe mental disorder requiring treatment
- Current or past substance use disorder, alcoholism, or alcohol dependence
- Major medical problems that can impact brain function, including HIV; central nervous system disorders such as seizures or psychosis; cardiovascular conditions such as hypertension and arrhythmias; metabolic, autoimmune, or endocrine disorders
- Previous radiation exposure (from X-rays, PET scans, or other exposure) that, with the exposure from this study, would exceed annual research limits
- Head trauma with loss of consciousness for more than 30 minutes
- Positive test for illicit drugs on any day of study
- Presence of metal objects in the body that prevent MRI of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments)
- Other MRI contraindications: fear of enclosed spaces; cannot lie comfortably flat on back for up to 2 hours in the PET and MRI scanners; weight of more than 250 pounds
The main goal of this study is to improve measures of brain functional connectivity in participants at rest and during task performance. Secondary objectives are to assess the dynamic properties and energy requirements of the human brain connectome (detailed circuitry of the living brain), as well as the effects of gender and aging on measures of brain functional connectivity.
Participants will undergo two MRI sessions and one 18F-Fluorodeoxyglucose (FDG)-PET session to assess the association between functional connectivity and glucose metabolism in the human brain. During the first visit, participants will be screened with a medical history, physical exam, and interview about drug and alcohol use and psychiatric history. They will give blood and urine samples, and their breath will be tested for alcohol and smoking. On the second visit, participants will have MRI scans, some while resting and some while doing tasks on a computer. During the third visit, participants will have urine collected and undergo an FDG-PET scan. Participants may also have tests of memory, attention, concentration, and thinking. Participants will wear a device for 1 week between visits to measure activity and sleep.
National Institutes of Health Clinical Center, 9000 Rockville Pike
For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
|Dardo G. Tomasi||Principal Investigator||National Institute on Alcohol Abuse and Alcoholism (NIAAA)|
|Dardo G. Tomasifirstname.lastname@example.org|
Reliability Of The Human Brain Connectome
- Sporns O. The human connectome: a complex network. Ann N Y Acad Sci. 2011 Apr;1224:109-25. doi: 10.1111/j.1749-6632.2010.05888.x. Epub 2011 Jan 4. Review.
- Lu H, Stein EA. Resting state functional connectivity: Its physiological basis and application in neuropharmacology. Neuropharmacology. 2014 Sep;84C:79-89. doi: 10.1016/j.neuropharm.2013.08.023. Epub 2013 Sep 4. Review.
- Kelly C, Biswal BB, Craddock RC, Castellanos FX, Milham MP. Characterizing variation in the functional connectome: promise and pitfalls. Trends Cogn Sci. 2012 Mar;16(3):181-8. doi: 10.1016/j.tics.2012.02.001. Epub 2012 Feb 15. Review.