Rehabilitation Intervention for Amnestic Mild Cognitive Impairment
The overall goal of this pilot project is to refine delivery of the Memory Support System as a formal compensatory program for memory loss in people with mild cognitive impairment (MCI). Investigators will randomly assign 60 individuals with MCI and their care partners to notebook or computer training for either 6 weeks or 10 days, then compare participants' adherence to both types of training. The investigators will also collect data to determine if these interventions can sustain or improve functioning.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
++Enrolled as a research participant at the Alzheimer's Disease Research Center with a diagnosis of amnestic mild cognitive impairment (MCI)++Partner who has at least twice weekly contact with the participant++Dementia Rating Scale-2nd Edition score of 115 or greater; Functional Ability Questionnaire score below 6++Partner with Mini Mental State Exam (MMSE) score of 24 or greater++English as primary language
++Diagnosis other than amnestic MCI++Visual or hearing impairment or history of reading/writing disability sufficient to interfere with training++Baseline score on the self-report depression measure suggesting severe depression for either participant or partner and need for psychiatric treatment++Taking nootropic(s) (drugs or foods taken to enhance cognition); may take if stable for at least 3 months
Mild cognitive impairment (MCI) is often an early manifestation of Alzheimer's disease. Interventions that help sustain functioning in people with MCI may delay progression to Alzheimer's. To date, interventions aimed at maintaining functioning in people with MCI have been pharmacologic in nature. Those with MCI are also often interested in other activities they can do to manage memory loss.
A recommendation is often given for the person with MCI to begin taking notes and/or using a calendar to help with memory or do cognitively stimulating activities. However, there is currently little instruction about specific activities one should do and how effective they may be.
The overall goal of this pilot project is to refine delivery of the Memory Support System (MSS) as a formal compensatory program for memory loss in MCI. Investigators will randomly assign 60 individuals with MCI and their care partners to notebook or computer training for either 6 weeks or 10 days, then compare participants' adherence to both types of training. The investigators will also collect data to determine if these interventions can sustain or improve functioning. All participants will also receive patient education regarding MCI and cognitive health.
Long-term goals for this project include delaying relocation for people with MCI who may progress to dementia, not only improving their lives but also reducing health care expenditures. Subsequent compliance with the MSS will be examined at 3 months, 6 months, and then annually following the intervention. Outcome measures will provide a detailed assessment of participants' functional level, overall cognitive functioning, mood, and self-efficacy, as well as caregiver burden and mood.
Mayo Clinic - Scottsdale
- Mayo Clinic
- National Institute of Nursing Research (NINR)
|Melanie Greenaway, PhD||Principal Investigator||Emory University|
|Dona Locke, PhD||Principal Investigator||Mayo Clinic|
|Melanie Greenaway, PhDfirstname.lastname@example.org|
A Multicenter Rehabilitation Intervention for Amnestic Mild Cognitive Impairment