Rehabilitation and Prevention of Word-Finding Problems in Primary Progressive Aphasia
This study is designed to remediate word-finding problems in people with primary progressive aphasia (PPA) and to delay further progression of word-finding impairment.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
- Diagnosis of PPA, including frontotemporal dementia, semantic dementia, or a similar condition
- At least 10 years of education
- Ability to follow spoken instructions
- Medically stable
- First language is English, or fluent in English since childhood
- Willing to participate for 2 years
- History of additional neurological problems
- History of substance abuse or psychiatric problems
People with PPA whose ability to name pictures has just begun to decline will receive practice in two conditions: viewing the picture and repeating the name, and viewing the picture with its written name plus reading and writing the name. Naming of pictures in each of these conditions will be compared after training with naming of pictures before the study.
Researchers predict that pairing the picture with its written name, combined with the motor task of writing the name, will result in a greater ability to name the picture at a later date than simply viewing the picture and repeating the name.
Investigators will attempt to strengthen neural connections that remain functional, making them more resistant to degradation as the disease progresses. While the study is specific to word-finding problems, a successful outcome would bode well for other studies aimed at prevention or reversal of declining cognitive functions in people with dementia.
Georgetown University Medical Center
||Washington||District of Columbia||20057||Recruiting||
Sarah Snider, MA
Johns Hopkins University
Donna Tippett, MA
- National Institute on Deafness and Other Communication Disorders (NIDCD)
- Johns Hopkins University
|Rhonda Friedman, PhD||Principal Investigator||Georgetown University|
|Aaron Meyer, PhDfirstname.lastname@example.org|