Skip to main content
U.S. flag

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock (  ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Find more clinical trials

Pupillary Response to Identify Progressive Supranuclear Palsy

Start: November 1, 2017
End: October 2019
Enrollment: 56

What Is This Study About?

This study will investigate pupillary light response as a potential detection method for progressive supranuclear palsy (PSP) in adults with PSP or other neurodegenerative diseases.

Do I Qualify To Participate in This Study?

Minimum Age: 55 Years

Maximum Age: N/A

Must have:

  • Meet clinical criteria for PSP, including recurrent falls and unsteady gait, rigidity of the neck and trunk, trouble controlling facial muscles, lid retraction in both eyes, trouble voluntarily shifting gaze, atrophy in the midbrain as shown on magnetic resonance imaging; PSP with asymmetric findings, tremors, and poor responses to treatment with the drug levodopa; or Parkinson's disease with progressive slow movement, postural instability and frequent falls, hurried gait with loss of associated movements, muscular rigidity and mask-like face, and resting tremors
  • Diagnosis of Alzheimer's disease with progressive impairment of memory and cognitive domains, such as language and visuospatial perception

Must NOT have:

  • Frail or in questionable health
  • Cataracts, age-related macular degeneration, open-angle glaucoma, or other optic nerve damage or posterior pole condition
  • Painful light sensitivity, for example, from corneal inflammation, uveitis (inflammation of the middle layer of the eye), or achromatopsia (partial or total absence of color vision)
  • Advanced dementia with inability to sit erect or hold eyes open, or incontinence
  • Epilepsy
  • Major depression or other severe psychiatric disorders

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Study Contact
Shirley H Wray, MD, PhD

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Massachusetts
Massachusetts General Hospital
Boston, MA 02114
Recruiting
Shirley H Wray, MD, PhD, FRCP

Who Sponsors This Study?

Lead: Massachusetts General Hospital

Collaborator Sponsor

  • NeurOptics Inc.
  • University of Toronto

Source: ClinicalTrials.gov ID: NCT03330353

alzheimers.gov

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health