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Preventing Alzheimer's Disease with Cognitive Training (PACT)


This study will test the feasibility of a long-term cognitive training trial in older adults with normal cognition.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A All Yes
February 20, 2019
June 30, 2020

  • Speak and understand English
  • Physical, visual, and hearing abilities needed to perform computer exercises, read from a computer screen at a typical viewing distance, understand conversational speech, and touch a computer screen or control a computer mouse
  • No evidence of mild cognitive impairment or dementia, as assessed by a Montreal Cognitive Assessment score of 26 or more
  • No self-reported diagnoses of mental illness that would interfere with study

  • Enrolled in another randomized clinical trial, treatment trial, or another research study that assesses cognition
  • Previous participation in a USF Cognitive Aging Lab cognitive training study
  • Self-reported vision, hearing, or motor difficulties that would interfere with the ability to complete the study interventions
  • Self-reported diagnosis of mild cognitive impairment, dementia, stroke, traumatic brain injury, brain tumor, or a neurological disorder that affects cognition or would interfere with the ability to benefit from the study intervention (e.g., Parkinson's disease, multiple sclerosis) or any other unstable medical condition associated with cognitive or functional decline (e.g., congestive heart failure, chronic obstructive pulmonary disorder dependent on oxygen, or undergoing chemotherapy or radiation)
  • Self-reported use of medications typically prescribed for dementia (memantine, donepezil, rivastigmine, galantamine)
  • Completion of 10 or more hours of a computerized cognitive training program in the last 5 years (e.g., Lumosity, Posit Science Brain Fitness, InSight, Brain HQ, Lace, CogMed, CogniFit, Happy Neuron, or Dakim)
  • Severe depressive symptoms (Geriatric Depression Scale score of 5 or greater)

Participants will be randomly assigned to complete 45 sessions of the cognitive training intervention or computer games, such as Sudoku and crossword puzzles, over a 3-year period. The cognitive training intervention consists of speed of processing training, designed to enhance cognition by increasing the amount of information one can quickly process. Researchers will assess the number of participants who enroll and stay enrolled in the study, as well as study demographics and people's willingness to participate in a long-term trial.

For more information, visit the PACT study website.

Name City State Zip Status Primary Contact
University of South Florida
Tampa Florida 33620 Recruiting Cognitive Aging Lab
Michigan State University
Grand Rapids Michigan 49503 Recruiting Baraa Abu-Dalu

University of South Florida

  • Michigan State University
  • National Institute on Aging (NIA)

Name Phone Email
Jerri Edwards, PhD 813-974-8572
Alisa Houseknecht 813-974-8572


Preventing Alzheimer's Disease With Cognitive Training: The PACT Trial