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Precision Rehabilitation to Counteract Age-Related Cognitive Decline


This study will examine how different types of training activity affect older adults' cognitive function, brain structure, biomarkers of brain health and cognition, and physical function. In addition, the study will assess how an individual's cognitive and physical characteristics influence their responsiveness to each type of training activity.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years 80 Years All Accepts Healthy Volunteers
September 1, 2018
December 31, 2020

  • Sedentary (regular participation over the past 3 months in less than 60 minutes per week of moderate-to-vigorous leisure-time or transportation-related physical activity performed in bouts of less than 10 minutes)
  • Able to move around independently with or without a cane or walking stick
  • Able to walk at least 400 meters

  • Engaging in regular aerobic exercise, resistance exercise, or yoga exercise over the past 3 months
  • History of stroke, uncontrolled resting hypertension (systolic blood pressure of 150 mmHg or diastolic blood pressure of 100 mmHg), congestive heart failure, recent myocardial infarction, or other contraindications to engagement in moderate-intensity physical activity for at least 10 continuous minutes
  • Incompatibility with magnetic resonance imaging (e.g. claustrophobia, metal implants, body size)
  • Consuming more than 1 alcoholic drink per day or more than 4 days per week, or current treatment for substance use disorder
  • Use of a walker or rolling walker
  • Short Physical Performance Battery score of less than 6 or unable to perform any of the 3 components of the total score
  • Depressive symptoms not controlled or treated.
  • Degenerative neurological condition (e.g., Parkinson's disease, multiple sclerosis)
  • Severe respiratory disease (e.g., chronic obstructive pulmonary disease with shortness of breath) or use of supplemental oxygen
  • Amputation or prosthesis affecting lower limb below or above the knee
  • Modified Mini-Mental State Exam score less than 85

Participants will be randomly assigned to one of four training activities:

  • Moderate-intensity aerobic exercise
  • Resistance exercise
  • Yoga
  • Health education (includes light stretching and range of motion activities)

Participants will attend one supervised session each week and will complete the remaining sessions on their own without supervision. Participants in the first three groups will progress to 150 minutes of exercise per week. The study period is 1 year. Participants will undergo physical, imaging, neuropsychological and other assessments at 3, 6, and 12 months.

Name City State Zip Status Primary Contact
University of Pittsburgh
Pittsburgh Pennsylvania 15260 Recruiting John M. Jakicic, PhD

University of Pittsburgh

Name Role Affiliation
John M. Jakicic, PhD Principal Investigator University of Pittsburgh
Fabrisia Ambrosio, PhD Principal Investigator University of Pittsburgh

Name Phone Email
John M Jakicic, PhD 412-383-4061
Susan Barr, BS 412-383-4061


A Precision Rehabilitation Approach to Counteract Age-Related Cognitive