This study will examine participants with Alzheimer's disease or a related dementia who have difficult behaviors that are upsetting for them or their caregivers. Research with prazosin, a medication commonly used to treat people with high blood pressure, has shown that it may be effective in treating behavioral problems in people with dementia.
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This study will examine participants with Alzheimer's disease or a related dementia who have difficult behaviors that are upsetting for them or their caregivers. Participants will be treated with prazosin, a medication commonly used to treat people with high blood pressure, to see if it is effective in treating behavioral problems by reducing excess adrenalin effects in the brain.
This is a 24-week study with 14 visits to the research clinic. Approximately six of these visits may be done by phone. Additional phone checks are scheduled at the beginning of each 12-week part of the study. Participants will have a 50/50 chance of being on prazosin or a placebo (a sugar pill) in the first 12 weeks of the study. For the second 12 weeks, all participants will take prazosin. Study visits include a physical and neurological exam, memory testing, interviews with the caregiver about behaviors, and vital signs.
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Geolocation is 47.5405059, -122.3045438
Seattle Institute for Biomedical and Clinical Research
National Institute on Aging (NIA)
VA Puget Sound Health Care System
Elaine R. Peskind, MD
University of Washington, VA Puget Sound Health Care System
Lucy Wang, MD