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Pomegranate Extract and Memory


This study will examine whether pomegranate extract benefits cognitive abilities in middle-aged and older people without dementia. Investigators expect that participants who take pomegranate extract supplement will show better cognitive performance than those who receive a placebo, though response will vary according to a genetic risk for Alzheimer's.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years 75 Years Both Accepts Healthy Volunteers
October 2011
January 2015

  • Normal cognition or mild cognitive impairment
  • Adequate seeing and hearing ability to allow neuropsychological testing
  • Normal results for screening laboratory tests and EKG; if results are abnormal, participant must obtain primary care physician's written clearance

  • Diagnosis of probable Alzheimer's disease or other dementia such as vascular, Lewy body, or frontotemporal
  • Evidence of other neurological or physical illness that can produce cognitive deterioration
  • Significant cerebrovascular disease, myocardial infarction within the previous year, unstable cardiac disease, or uncontrolled hypertension (systolic blood pressure over 170 mmHg or diastolic blood pressure over 100 mmHg)
  • History of stroke, transient ischemic attack, carotid bruits, or lacunes seen on MRI scans
  • Contraindication to MRI, including claustrophobia, metal in body, surgery within 60 days, certain implants or previous abnormal MRI results
  • Evidence of Parkinson's disease
  • History of significant liver disease, clinically significant pulmonary disease, or diabetes
  • Current diagnosis of any major psychiatric disorder, current or past alcoholism or substance addiction
  • Regular use of any medication that may affect cognitive functioning: centrally active beta-blockers, narcotics, clonidine, antiparkinsonian medications, antipsychotics, systemic corticosteroids, medications with significant cholinergic or anticholinergic effects, anticonvulsants, or warfarin
  • Occasional use of anxiety or sleeping medications known to cause cognitive dulling will be allowed but discouraged: chloral hydrate, nonbenzodiazepine hypnotics such as zolpidem (Ambien®), eszopiclone (Lunesta®), and benzodiazepines such as lorazepam (Ativan®), alprazolam (Xanax®), clonazepam (Klonopin®), and temazepam (Restoril®)
  • Prohibited medications: amitriptyline, amiodarone, desipramine, fenofibrate, flecainide, fluconazole, fluoxetine, fluvastatin, fluvoxamine, isoniazid, lovastatin, ondansetron, phenylbutazone, probenecid, sertraline, sulfamethoxazole, sulfaphenazole, teniposide, voriconazole, warfarin, and zafirlukast
  • Use of cognitive-enhancing supplements such as ginkgo biloba; use of any supplement containing pomegranate or pomegranate juice; use of any investigational drugs within the previous month or longer, depending on drug half-life
  • Pregnancy

Participants will be randomly assigned to take a 1,000-mg pomegranate extract supplement or a placebo every day for 1 year. Their cognitive performance will be tested and compared at the start of the study and after 1, 6, and 12 months. Pomegranate juice is a dietary source of polyphenol antioxidants.

Name City State Zip Status Primary Contact
UCLA Longevity Center
Los Angeles California 90095

University of California, Los Angeles

  • POM Wonderful LLC

Name Role Affiliation
Gary Small, MD University of California, Los Angeles

Name Phone Email
Jacqueline Martinez 310-206-1319


12-Month, Double-blind, Placebo-Controlled Study of Pomegranate Extract