Start:
August 2013
End:
August 2015
Enrollment:
30
What Is This Study About?
This observational study will examine the relationship between physical activity levels, brain structure, and memory function in adults with mild cognitive impairment during 18 months. During this time, participants' physical activity levels will be measured regularly and related to both the thickness of the hippocampus (a brain structure important to memory and learning) and to performance on memory tests.
Do I Qualify To Participate in This Study?
Must have:
- Diagnostic criteria for MCI: subjective memory complaints, Montreal Cognitive Assessment score of less than 26, and intact instrumental activities of daily living or subjective age-associated memory complaints
- Living with an adult who can ensure correct usage of the physical activity monitors during the study and verify self-reports of activity levels
- Adequate seeing and hearing abilities to allow neuropsychological testing
- Screening laboratory tests and EKG without significant abnormalities that might interfere with the study; principal investigator may request clearance from primary care physician before subject continues in study
Must NOT have:
- Comorbid conditions impacting mobility
- Current, untreated depression (BDI-II score of greater than 13)
- Diagnosis of probable Alzheimer's disease or any other dementia; evidence of other neurological or physical illness that can produce cognitive deterioration
- History of head trauma, stroke, transient ischemic attack, carotid bruits, or lacunes on MRI scans
- Contraindication to MRI scanning, including claustrophobia, metal in body, surgery within 60 days, certain medical implants or previous abnormal MRI results
- History of cardiovascular disease; uncontrolled hypertension (systolic blood pressure of more than 170 or diastolic blood pressure of more than 100)
- Current diagnosis of any major psychiatric disorder according to the DSM-IV TR criteria, including current alcoholism or substance addiction
- Current use of marijuana; previous use of marijuana for at least 15 days in a month, initiating use during adolescence and continuing for at least 1 year
Need Help?
Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at
800-438-4380
or
email ADEAR.
Where Is This Study Located?
Source:
ClinicalTrials.gov ID:
NCT02001441