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Novel Computerized Cognitive Stress Test


This study will examine the reliability and validity of the Cognitive Stress Test (CST) in distinguishing between early-stage mild cognitive impairment (eMCI) and cognitively normal older adults. Researchers will also study the relationship between baseline biomarkers and baseline performance on the CST versus another cognitive assessment, called the ADAS Cog-13, among individuals with eMCI.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years N/A All Yes
May 22, 2019
November 30, 2023

Participants with Early-Stage MCI

  • Meet the criteria for amnestic MCI
  • If taking donepezil, rivastigmine, galantamine, memantine or any potential memory-enhancing agent, on stable dose for at least two months

Cognitively Normal Participants

  • No evidence of a memory complaint, confirmed by an informant
  • Global Clinical Dementia Rating Scale of 0
  • No impairment in social and/or occupational function
  • No major neurocognitive disorder
  • Normal neuropsychological scores 

  • Significant sensory or motor deficit (e.g., visual or hearing impairment, paralysis)
  • Literacy lower than the sixth grade level 
  • Major depressive disorder, bipolar disorder, psychotic disorder, substance use disorder or any other psychiatric condition 
  • Prohibited medications: antipsychotics, sedatives or other agents with significant anticholinergic properties

Half the participants in this five-year observational study will be Hispanic older adults who speak Spanish as their primary language; the other half will be non-Hispanic older adults who speak English as their primary language. All participants will receive a yearly clinical and neuropsychological evaluation, baseline blood test and MRI scan. A subgroup of individuals will also undergo PET imaging for amyloid and tau protein levels. Importantly, all research participants will be administered the CST, which is thought to be sensitive to preclinical (asymptomatic) Alzheimer's disease.

Name City State Zip Status Primary Contact
University of Miami
Miami Florida 33146 Recruiting Ingrid Usaga

University of Miami

  • National Institute on Aging

Name Role Affiliation
David Loewenstein, PhD Principal Investigator University of Miami

Name Phone Email
Ingrid Usaga 305-355-9037