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North American Prodromal Synucleinopathy (NAPS) Consortium

Recruiting

This study is enrolling adults with idiopathic rapid eye movement (REM) sleep behavior disorder to create a trial-ready cohort for potential treatments for synucleinopathies. Synucleinopathies are neurodegenerative disorders, including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy, associated with the buildup of the protein alpha-synuclein in the brain.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All No
August 29, 2018
July 31, 2021
300

  • Idiopathic REM sleep behavior disorder

  • REM sleep behavior disorder secondary to another cause, such as narcolepsy, dementia, or Parkinson's disease
  • Other neurological disorder

People with REM sleep behavior disorder act out their dreams, and often, but not always, develop a neurodegenerative disease of the synucleinopathy type. The NAPS Consortium was formed to enroll people with sleep behavior disorder to collect standardized clinical assessments, biofluids, and other data in order to identify biological signs, or biomarkers, of synucleinopathies in the presymptomatic, or prodromal, stage and to assemble a trial-ready registry. Participant procedures will include a roughly 2-hour clinical assessment, including medical history and physical exam, questionnaires, blood draw, and optional lumbar puncture.

Name City State Zip Status Primary Contact
University of California Los Angeles
Los Angeles California 90095 Recruiting Adreanne Rivera
310-794-0213
adreannerivera@mednet.ucla.edu
Emory University
Atlanta Georgia 30322 Recruiting Cathy Wood-Siverio
404-712-6988
cwoodsi@emory.edu
Massachusetts General Hospital
Boston Massachusetts 02145 Recruiting Matthew Stauder
617-726-9589
mstauder@mgh.harvard.edu
University of Minnesota
Minneapolis Minnesota 55455 Recruiting Josh De Kam
612-626-8052
jadekam@umn.edu
Mayo Clinic
Rochester Minnesota 55905 Recruiting Ruth Kraft
507-284-1324
kraft.ruth@mayo.edu
Washington University
Saint Louis Missouri 63110 Recruiting Jennifer McLeland
314-747-6124
naps@wustl.edu
McGill University
Montréal Quebec HGH 2R9 Recruiting Amelie Pelletier
514-934-1934
amelie.pelletier@mail.mcgill.ca

Washington University School of Medicine

  • Mayo Clinic
  • University of Minnesota - Clinical and Translational Science Institute
  • University of California, Los Angeles
  • McGill University
  • Emory University
  • Massachusetts General Hospital
  • National Institute on Aging (NIA)

Name Role Affiliation
Yo-El Ju, MD Principal Investigator Washington University School of Medicine
Bradley Boeve, MD Principal Investigator Mayo Clinic

Name Phone Email
Yo-El Ju, MD 314-747-6124 info@naps-rbd.org
Jennifer McLeland naps@wustl.edu

NCT03623672

North American Prodromal Synucleinopathy Consortium