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North American Prodromal Synucleinopathy (NAPS) Consortium


This study is enrolling adults with idiopathic rapid eye movement (REM) sleep behavior disorder to create a trial-ready cohort for potential treatments for synucleinopathies. Synucleinopathies are neurodegenerative disorders, including dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy, associated with the buildup of the protein alpha-synuclein in the brain.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All No
August 29, 2018
July 31, 2021

  • Idiopathic REM sleep behavior disorder

  • REM sleep behavior disorder secondary to another cause, such as narcolepsy, dementia, or Parkinson's disease
  • Other neurological disorder

People with REM sleep behavior disorder act out their dreams, and often, but not always, develop a neurodegenerative disease of the synucleinopathy type. The NAPS Consortium was formed to enroll people with sleep behavior disorder to collect standardized clinical assessments, biofluids, and other data in order to identify biological signs, or biomarkers, of synucleinopathies in the presymptomatic, or prodromal, stage and to assemble a trial-ready registry. Participant procedures will include a roughly 2-hour clinical assessment, including medical history and physical exam, questionnaires, blood draw, and optional lumbar puncture.

Name City State Zip Status Primary Contact
Banner Sun Health Research Institute
Sun City Arizona 85351 Recruiting Daneva MinerRose
University of California Los Angeles
Los Angeles California 90095 Recruiting Adreanne Rivera
Stanford University
Redwood City California 94063 Recruiting Adrian Ekelmans
Emory University
Atlanta Georgia 30322 Recruiting Kelsey Tucker
Massachusetts General Hospital
Boston Massachusetts 02145 Recruiting Matthew Stauder
University of Minnesota
Minneapolis Minnesota 55455 Recruiting Josh De Kam
Mayo Clinic
Rochester Minnesota 55905 Recruiting Ruth Kraft
Washington University
Saint Louis Missouri 63110 Recruiting Jennifer McLeland
Portland VA Medical Center
Portland Oregon 97239 Recruiting Alisha McBride
McGill University
Montréal Quebec HGH 2R9 Recruiting Amelie Pelletier

Washington University School of Medicine

  • Mayo Clinic
  • University of Minnesota - Clinical and Translational Science Institute
  • University of California, Los Angeles
  • McGill University
  • Emory University
  • Massachusetts General Hospital
  • National Institute on Aging (NIA)

Name Role Affiliation
Yo-El Ju, MD Principal Investigator Washington University School of Medicine
Bradley Boeve, MD Principal Investigator Mayo Clinic

Name Phone Email
Yo-El Ju, MD 314-747-6124
Jennifer McLeland


North American Prodromal Synucleinopathy Consortium