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Neuroenergetic Adaptations in Alzheimer's Disease (PREPARE)

Recruiting

This observational study will investigate the relationship between brain energetics and risk for Alzheimer's disease in cognitively normal adults and those with mild cognitive impairment (MCI).

Minimum Age Maximum Age Gender Healthy Volunteers
70 Years 85 Years All Yes
May 1, 2019
December 1, 2020
45

Participants with Normal Cognition

  • Overall excellent health with normal cognition (Clinical Dementia Rating score of 0)
  • At least high school-level education

Participants with Mild Cognitive Impairment (MCI)

  • Clinical Dementia Rating score of 0.5 to 1
  • Mini-Mental State Examination score of 20 to 25
  • Proficient in English

  • Any tumor, stroke, or trauma that would result in abnormal radiological findings
  • History of bipolar disorder, schizophrenia, intellectual disability, or substance abuse
  • Metal implants, claustrophobia, or other conditions that would prevent magnetic resonance imaging (MRI)

The purpose of this study is to test whether there is a correlation between neuroenergetic levels of aerobic glycolysis/oxidative phosphorylation and risk for Alzheimer's disease. Participants will undergo positron emission tomography and MRI scans to measure activity in the brain. Specifically, researchers will be investigating processes involved in transforming food into energy, known as brain energetics, and the differences between people with and without MCI.

Name City State Zip Status Primary Contact
New York University School of Medicine
New York New York 10016 Recruiting Shannon Haas
212-263-0228
shannon.haas@nyulangonge.org

NYU Langone Health

Name Role Affiliation
Ryan Brown, MD Principal Investigator New York Langone Medical Center

Name Phone Email
Shannon Haas 212-263-0228 shannon.haas@nyulangone.org

NCT03999879

NEUROENERGETIC ADAPTATIONS IN ALZHEIMER'S DISEASE: IMPLICATIONS ON AMYLOID BURDEN AND COGNITION