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Natural History Study of Synucleinopathies

Recruiting

In this observational study, researchers will document the clinical features and biological markers of people with synucleinopathies (Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy) and those in a pre-dementia stage to better understand how these disorders evolve over time.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All No
June 2011
July 2020
800

  • Referred to any study site with orthostatic intolerance (dizziness or lightheadedness when standing that disappears when lying face upward)

  • Diabetes
  • Congestive heart failure
  • Lupus or other collagen vascular disease
  • Systemic illness thought to be responsible for orthostatic intolerance
  • Drug-induced orthostatic hypotension (e.g., the use of alpha-blockers, diuretics, and/or tricyclic antidepressants)
  • Isolated vasovagal syncope (fainting as a result of a sudden drop in blood pressure and heart rate)

Synucleinopathies are a group of rare diseases associated with worsening neurological deficits and abnormal accumulation of the protein alpha-synuclein in the nervous system. Researchers will follow people diagnosed with a synucleinopathy and those believed to be in a pre-dementia stage over a 5-year period. The study aims to find biological clues of disease progression that would allow for testing of disease-modifying strategies to delay or stop the neurodegenerative process.

Name City State Zip Status Primary Contact
Beth Israel Deaconess Medical Center
Boston Massachusetts Recruiting Sharika Rajan
617-632-0864
srajan@bidmc.harvard.edu
University of Michigan
Ann Arbor Michigan Recruiting Arijit Bhaumik, BA
734-936-8281
arijit@umich.edu
Mayo Clinic
Rochester Minnesota Recruiting Tonette Gehrking
507-284-0336
adc.research@mayo.edu
NYU Medical Center
New York New York 10016 Recruiting Jose Martinez, MA
212-263-7225
jose.martinez@nyumc.org
Vanderbilt Univeristy
Nashville Tennessee Recruiting Emily Garland, PhD
615-936-1748
emily.garland@Vanderbilt.Edu

New York University School of Medicine

Name Role Affiliation
Horacio C. Kaufmann, MD Principal Investigator NYU Medical Center

NCT01799915

Natural History Study of Synucleinopathies