MRI-Guided Transcranial Magnetic Stimulation for MCI
This study will test different doses and applications of transcranial magnetic stimulation (TMS) in adults with and without mild cognitive impairment (MCI), a precursor to Alzheimer's disease.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|50 Years||80 Years||All||Yes|
Participants with MCI
- Self- or informant-reported cognitive complaint
- Preserved independence in daily activities
- Absence of dementia
- Mini-Mental State Examination (MMSE) score of 24 to 27, Montreal Cognitive Assessment (MoCA) score of 18 to 26, or Clinical Dementia Rating (CDR) Scale score of 0.5
Cognitively Normal Participants
- No cognitive impairment (MMSE score of 27 or more, MoCA score of 26 or higher, and CDR scale score of 0)
- English speaking
- Able to attend daily weekday sessions for 4 weeks
- Not enrolled in another interventional study within 6 months prior to study start
- Inability to undergo transcranial magnetic stimulation or magnetic resonance imaging
- Other neurological disorders, such as stroke, head injuries, or multiple sclerosis
- Untreated depression
- Current cancer treatment or other medical problems that might affect study or results
TMS is a noninvasive procedure that involves the use of magnetic fields to stimulate areas of the brain. In this study researchers will compare the effects of short bursts of stimulation, applied continuously or intermittently, at low and high frequencies.
Participants will first undergo two separate sessions in which they receive continuous or intermittent stimulation to determine the optimal protocol for them based on memory tasks. Participants will then undergo 30-minute stimulation sessions Monday through Friday for 4 weeks. They will also participate in several 2- to 3-hour testing sessions involving brain imaging, neuropsychological testing, memory tasks, and other assessments throughout the study.
Bioscience Research Laboratory
Viet Ton That
MRI Guided Hippocampal Stimulation With Transcranial Magnetic Stimulation