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Modified Story Memory Technique (mSMT) to Enhance Memory

Recruiting

The Modified Story Memory Technique (mSMT) cognitive retraining program has been shown to improve new learning and memory function in individuals with multiple sclerosis and traumatic brain injury. This study will measure the effects of mSMT in cognitively healthy older adults and adults with mild cognitive impairment. Researchers will determine whether engaging in mSMT can enhance memory and learning ability.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A All Yes
November 1, 2017
November 1, 2021
40

  • English as the primary language

  • Diagnosis of any neurological condition such as Alzheimer's disease, dementia, stroke, multiple sclerosis, brain injury, Parkinson's disease
  • Diagnosis of a psychiatric disorder such as post-traumatic stress disorder, schizophrenia, bipolar disorder
  • Abuse of illicit drug within the past 6 months

Exclusion criteria for the optional functional magnetic resonance imaging (fMRI)

  • Pacemaker or other implanted electrical device, brain stimulator, aneurysm clip (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), permanent eyeliner, implanted delivery pumps, or shrapnel fragments
  • Dental implants
  • Left handedness

Participants will be randomly assigned to either an experimental group, which will receive memory retraining exercises, or a control group, which will receive placebo exercises. Exercises will be administered on a laptop computer twice a week for 5 weeks. Participants will undergo standardized neuropsychological tests of memory and complete other questionnaires before and after training and again at  6, 12, and 24 months after training. Functional magnetic resonance imaging (fMRI) scans will be conducted with participants who are willing and able to complete imaging procedures.

Name City State Zip Status Primary Contact
Kessler Foundation
East Hanover New Jersey 07936 Recruiting Nancy B Moore, MA
973-324-8450
nbmoore@kesslerfoundation.org

Kessler Foundation

Name Role Affiliation
Nancy D. Chiaravalloti, PhD Principal Investigator Kessler Foundation

Name Phone Email
Nancy B. Moore 973-324-8450 nbmoore@kesslerfoundation.org
Angela A. Smith, MA 973-324-8448 asmith@kesslerfoundation.org

NCT03370224

Application of the Modified Story Memory Technique (mSMT) to Aging