MIND Diet to Prevent Cognitive Decline
Active, not recruiting
This study will test the effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on cognitive decline in seniors without cognitive impairment who are overweight and have suboptimal diets. The MIND diet combines the Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH).
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|65 Years||84 Years||All||Yes|
- Suboptimal diet
- Body mass index greater than or equal to 25
- Family history of dementia
- Heavy alcohol use
- Severe illness
- Cognitive impairment
- Psychiatric illness
In this 3-year study, participants will be randomly assigned to eat either the MIND diet or their usual diet. The MIND diet emphasizes natural, plant-based foods, limits foods that are high in animal and saturated fats, and specifies green leafy vegetables and berries. Both groups will undergo mild caloric restriction for weight loss (250 calories a day) and will receive counseling to help reduce caloric intake. To assess the diet's effect on cognitive decline, researchers will measure changes in cognitive function and brain volume, as well as biomarkers of oxidative stress, inflammation, and Alzheimer's disease.
Harvard School of Public Health
MIND Diet Intervention to Prevent Alzheimer's Disease
- Morris MC, Tangney CC, Wang Y, Sacks FM, Barnes LL, Bennett DA, Aggarwal NT. MIND diet slows cognitive decline with aging. Alzheimers Dement. 2015 Sep;11(9):1015-22. doi: 10.1016/j.jalz.2015.04.011.
- Morris MC, Tangney CC, Wang Y, Sacks FM, Bennett DA, Aggarwal NT. MIND diet associated with reduced incidence of Alzheimer's disease. Alzheimers Dement. 2015 Sep;11(9):1007-14. doi: 10.1016/j.jalz.2014.11.009.