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MIND Diet to Prevent Cognitive Decline

Active, not recruiting

This study will test the effects of the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on cognitive decline in seniors without cognitive impairment who are overweight and have suboptimal diets. The MIND diet combines the Mediterranean diet and Dietary Approaches to Stop Hypertension (DASH).

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years 84 Years All Yes
January 2017
April 2021

  • Suboptimal diet
  • Body mass index greater than or equal to 25
  • Family history of dementia

  • Heavy alcohol use
  • Severe illness
  • Cognitive impairment
  • Psychiatric illness

In this 3-year study, participants will be randomly assigned to eat either the MIND diet or their usual diet. The MIND diet emphasizes natural, plant-based foods, limits foods that are high in animal and saturated fats, and specifies green leafy vegetables and berries. Both groups will undergo mild caloric restriction for weight loss (250 calories a day) and will receive counseling to help reduce caloric intake. To assess the diet's effect on cognitive decline, researchers will measure changes in cognitive function and brain volume, as well as biomarkers of oxidative stress, inflammation, and Alzheimer's disease.

For more information on this trial, visit

Name City State Zip Status Primary Contact
Rush University
Chicago Illinois 60612

Harvard School of Public Health
Boston Massachusetts 02115

Rush University Medical Center

  • Harvard School of Public Health
  • Brigham and Women's Hospital
  • National Institute on Aging (NIA)

Name Phone Email
Martha C. Morris, ScD 312-942-3223
Chiquia Hollings 312-943-2123


MIND Diet Intervention to Prevent Alzheimer's Disease