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Find more clinical trials

Mild Cognitive Impairment and Obstructive Sleep Apnea (MEMORIES)

Start: February 2012
End: December 2014
Enrollment: 110

What Is This Study About?

We are conducting a pilot clinical trial to compare the effects of active continuous positive airway pressure (CPAP) versus sham CPAP on cognitive and everyday function in 110 older adults with mild cognitive impairment (MCI) and obstructive sleep apnea.

Do I Qualify To Participate in This Study?

Minimum Age: 55 Years

Maximum Age: 89 Years

Must have:

++Moderate to severe obstructive sleep apnea as dened by an apnea-hypopnea index (AHI) score of 15 or greater, using either the Apnea Risk Evaluation System (ARES) or diagnostic polysomnography ++Score of 11 or less on the Dementia Severity Rating Scale++Education-adjusted total score of less than 26 on the Montreal Cognitive Assessment++Education-adjusted score of 28-35 (inclusive) on the Telephone Interview for Cognitive Status Modified++Score of 14 or less on the Beck Depression Inventory II (not depressed)++Study partner, dened as an informant/caregiver who has an average of 10 hours per week or more contact with participant and can accompany him/her to most study visits++Adequate visual and hearing acuity to allow testing++Women only: surgically sterile or 2 years postmenopausal++At least six grades of education or a good work history inside or outside the home ++Fluent in English

Must NOT have:

++Signicant neurologic disease other than mild cognitive impairment (MCI), such as Parkinson's disease, Huntington's disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, seizure disorder, subdural hematoma, multiple sclerosis, or history of signicant head trauma followed by persistent neurologic defects or known structural brain abnormalities++Presence of pacemakers, aneurysm clips, articial heart valves, ear implants, metal fragments or foreign objects in the eyes, skin, or body that preclude MRI examination++Psychiatric disorders, including major depression or bipolar disorder in the past 3 months, psychotic features, agitation or behavioral problems in the past 3 months that could lead to difficulty complying with the protocol, or history of schizophrenia ++History of alcohol abuse or dependence in the past 2 years ++Current signicant systemic illness or unstable medical condition that could lead to difficulty complying with the protocol++Current conditions that may increase short-term risk from untreated obstructive sleep apnea: symptomatic coronary or cerebrovascular disease, as indicated by recent myocardial infarction or stroke (6 months); congestive heart failure; unstable angina; life-threatening arrhythmias; cardiomyopathy; transient ischemic attacks; and history of driving accidents related to daytime sleepiness++Participation in clinical studies involving neuropsychological measures being conducted more than twice a year or another clinical trial++Prohibited medications: Receiving CPAP or bilevel pressure for obstructive sleep apnea; need oxygen or bilevel pressure during CPAP titration polysomnography; regular use of bronchodilators or steroids; use of supplemental oxygen

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: George Mason University

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT01482351

alzheimers.gov

An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health