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Middle-Aged Offspring of Late Alzheimer's Probands: Novel Cognitive and Biomarker Assessment (O-LOAD)


This study is designed to look at differences between middle-aged children of parents with late-onset Alzheimer's disease and middle-aged children whose parents do not have the disease.

Minimum Age Maximum Age Gender Healthy Volunteers
35 Years 59 Years All Yes
July 31, 2019
July 31, 2021

  • Have at least one parent with a diagnosis of late-onset Alzheimer's (onset of symptoms greater than 65 years of age) or do not have a parent with late-onset Alzheimer's and no family history of the disease

  • Presence of significant sensory or motor deficit (such as vision or hearing loss, paralysis)
  • Literacy lower than seventh grade
  • Major depressive disorder, bipolar disorder, psychotic disorder, substance use disorder or any anxiety disorder
  • Dysphoric mood (state of unease or dissatisfaction)
  • Prohibited medications: antipsychotics, benzodiazepines, anti-epileptics, or other agents with significant anticholinergic or central nervous system depressant properties

The study will recruit 60 middle-aged children of a parent with late-onset Alzheimer's and 60 middle-aged children who do not have a parent with Alzheimer's. All individuals will receive extensive baseline clinical and neuropsychological evaluations, computerized cognitive batteries, genetic analysis, and structural and functional brain MRI scans. All research participants will be administered a cognitive stress test.

Name City State Zip Status Primary Contact
University of Miami
Miami Florida 33146 Recruiting Sindy Jaramillo

University of Miami

  • Florida Department of Health

Name Role Affiliation
David Loewenstein, PhD Principal Investigator University of Miami

Name Phone Email
Sindy Jaramillo 305-355-9062