Alzheimer's Disease Education and Referral Center

Memory and Thinking Problems in Older Adults After Surgery

Memory and Thinking Problems in Older Adults After Surgery

Overall Status: 
Brief Description: 

The purpose of this study is to examine if and how brain scans can predict decline in memory and executive functioning in older adults after total knee replacement surgery.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
60 Years
Inclusion Criteria: 
    • Planned total knee antroplasty in one knee or nonsurgical knee osteoarthritis
    • Right-handedness
    • No difficulties with Instrumental Activities of Daily Living
Exclusion Criteria: 
    • Signs of dementia, based on telephone screening and baseline cognitive testing
    • Underlying medical diseases likely to limit life span or confound outcome analyses, including: cancer requiring treatment in the past 5 years, serious infectious diseases, congestive heart failure, chronic hepatitis, history of organ transplantation, seizure disorders, or history of head trauma resulting in intensive care
    • Current diagnosis of alcoholism, drug dependence; history of major tranquilizer use
    • Neurodegenerative conditions, including: history of major stroke; exposure to toxins or neuroleptics; history of encephalitis; neurological signs of motor neuron disease, cerebellar involvement, supranuclear palsy, or significant orthostatic hypertension
    • Psychiatric conditions, including: major psychiatric disorder, major depression, claustrophobia
    • Nonmedical metal in body; pacemaker device
    • Less than 5 years of formal education; inability to read or write
    • Self-reported hearing difficulty that interferes with standardized test administration
Detailed Description: 

Many older adults experience cognitive impairment after major surgery. The results of previous studies indicate that certain neuroimaging tests can determine which individuals are most likely to have such impairment. In this study, researchers will use magnetic resonance imaging (MRI) to determine which patients having total knee replacement surgery, a common operation, are most likely to become cognitively impaired after their surgery.

A total of 80 patients undergoing surgery will be compared with 80 controls of similar age, education, and health status. All participants will receive cognitive testing and MRI brain scans before and after surgery/non-surgery. Researchers will compare and monitor both groups for up to 1 year. Cognitive assessments will be conducted for each participant at 3 weeks, 3 months, and 1 year after surgery.

The findings of the study are expected to improve presurgery screening procedures for older adults and assist with the development of interventions during surgery that will prevent neurodegenerative disease acceleration.

Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 29.63923, -82.34331

University of Florida
Donna Weber
Lead Sponsor: 
University of Florida
Collaborator Sponsor: 
National Institutes of Health (NIH)
National Institute of Nursing Research (NINR)
Facility Investigators: 
Catherine Price, PhD
Principal Investigator
University of Florida
Study Contact: 
Donna Weber
Locations ID 
NCT01786577 (follow link to view full record on in new window)
Official Title: 
Neuroimaging Biomarkers for Post-Operative Cognitive Decline in Older Adults
Study Start Date: 
March 2013
Study End Date: 
June 2018