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Magnesium L-Threonate to Enhance Learning and Memory in People with Dementia


This study will examine the effects of taking a dietary supplement, magnesium L-threonate (brand name, Magtein), in people with mild to moderate dementia and a magnesium deficiency to see if it will improve memory and/or magnesium deficiency.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years N/A Both No
July 2014
July 2016

  • Mini-Mental State Examination score of 16-24
  • Adequate seeing and hearing ability to allow neuropsychological testing
  • More than 12 years of educational achievement or a General Education Development certificate
  • Women must be surgically sterile, postmenopausal, or use an acceptable method of birth control

  • Active heart disease
  • Uncontrolled high blood pressure (≥ 140/90 mmHg)
  • Renal or hepatic impairment/disease
  • Type I diabetes
  • Unstable thyroid disease
  • Psychiatric disorder requiring hospitalization in the past year
  • Drug or alcohol abuse in the past 12 months
  • Immune disorder such as HIV/AIDS
  • Transient ischemic attacks, carotid bruits, or verified lacunes
  • Significant pulmonary disease
  • Contraindication for PET scan, including a stroke or heart attack in the past 6 months or inability to lie down for 1 hour
  • History of cancer (except localized skin cancer without metastases or in situ cervical cancer) within 5 years prior to screening
  • Prohibited medications: medications known to interact with magnesium; antibiotics;  vitamins, minerals or dietary/herbal supplements other than the study product until after study completion
  • On an unstable dose of medication (defined as fewer than 90 days at the same dose)
  • Allergy or sensitivity to any ingredient in the test product
  • Pregnant , lactating, or planning to become pregnant during the study period
  • Participation in another research study within 30 days prior to the screening visit

All participants will take the study drug for 60 days, one pill in the morning and two pills 2 hours before bedtime. Each pill contains 600 mg of magnesium L-threonate, a dietary supplement that plays a role in many brain functions. In this study, it is being tested to see it can improve memory in people with mild to moderate dementia. Participants will undergo neurocognitive assessments, PET brain scans, and blood tests.

Name City State Zip Status Primary Contact
Stanford University School of Medicine, Department of Psychiatry & Behavioral Sciences
Stanford California 94305

Stanford University

  • Magceutics Inc.

Name Role Affiliation
Natalie L. Rasgon, MD, PhD Principal Investigator Stanford University School of Medicine


The Use of Magnesium L-Threonate for the Enhancement of Learning and Memory in People With Mild to Moderate Dementia