Light and Cognitive Therapy for Alzheimer's Disease
This observational study will test the ability of an iPad app to improve cognition, function, and quality of life in people with Alzheimer's disease. The app delivers light therapy at 40 Hz while users play cognitive games.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
|50 Years||N/A||All||Accepts Healthy Volunteers|
- Alzheimer's disease
- Cognitive impairment
- Previous epileptic seizures, including febrile seizures
- Significant disease of the eye, such as macular degeneration
Electrical activity in the brain known as gamma brainwaves helps connect and process information throughout the brain. These gamma waves are diminished in Alzheimer's disease. New research suggests that exposure to a light flickering at 40 Hz may promote gamma-wave brain activity, which could potentially activate cells in the brain to eliminate beta-amyloid plaques. These plaques are implicated in Alzheimer's disease. For a 1-year study period, participants will use an iPad app ("ALZLIFE") on a daily basis to play cognitive games (e.g., Sudoku, Tic-Tac-Toe) while being exposed to light therapy at 40 Hz. On a monthly basis, the participant's caregiver will use the iPad app to report on the participant's past-month competence in activities of daily living.
Alzheimer's Light LLC
|Andrey Vyshedskiy, PhDfirstname.lastname@example.org|
An Observational Trial of Alzheimer's Disease Treatment With Combination of 40Hz Light and Cognitive Therapy
- Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 Dec 7;540(7632):230-235. doi: 10.1038/nature20587. Erratum in: Nature. 2018 Jul 25;:.
- Thomson H. How flashing lights and pink noise might banish Alzheimer's, improve memory and more. Nature. 2018 Mar 1;555(7694):20-22. doi: 10.1038/d41586-018-02391-6.