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Lifestyle Activities for Brain Health


This study will examine the effects of exercise and healthy living education on brain health, cognition, and physical function in older adults with cognitive concerns.

Minimum Age Maximum Age Gender Healthy Volunteers
60 Years 80 Years All Yes
July 2016
April 2020

  • Sedentary behavior
  • Subjective or objective cognitive impairment
  • Mini-Mental State Examination score greater than 26
  • At least 1 standard deviation below normative values on cognitive tests
  • Modified Hachinski Ischemic score greater than 4
  • Ability to complete both magnetic resonance imaging (MRI) and positron emission tomography (PET) scans
  • Physically capable of completing health programs
  • Fluent in English

  • Evidence of dementia
  • History of a neurological disorder
  • Current psychiatric illness
  • History of head trauma with a loss of consciousness greater than 10 minutes
  • Severe sensory deficits (e.g., hearing or vision)
  • Substance abuse
  • Depression
  • Inability to perform intervention (e.g., walk without assistance)
  • Inability to undergo MRI scan (e.g., pacemaker)

Modifiable lifestyle activities, such as exercise and healthy living, have the potential to slow cognitive decline and delay the onset of Alzheimers disease. However, the effect of such activities on people with mild cognitive impairment is not well understood. In this study, participants with cognitive concerns will engage in either moderate-aerobic walking or healthy living education for 6 months. Researchers will examine changes in brain function, memory, and physical function.

Name City State Zip Status Primary Contact
University of Southern California
Los Angeles California 90032 Recruiting Judy Pa, PhD

University of Southern California

Name Phone Email
Lisette Isenberg, PhD 323-442-0141


Lifestyle Enriching Activities for Research in Neuroscience Intervention Trial: LEARNit Study