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Virtual Reality Video Game for Long-Term Memory


This study will test the effect of Labyrinth, a virtual reality video game, on memory in older adults and people with mild cognitive impairment.

Minimum Age Maximum Age Gender Healthy Volunteers
62 Years 85 Years All Yes
October 1, 2019
June 2022

  • Fluent speaker of English
  • Completion of 12 or more years of education
  • Normal or corrected-to-normal vision
  • Ability to comfortably operate the video game instruments
  • No physical or neurological conditions that would prevent an MRI
  • Physical stamina and comfort sufficient for 45-minute, brisk walks on level ground

  • Use of psychotropic medications
  • History of concussions or problems with dizziness
  • History of problems maintaining balance, posture, or the body's orientation in space
  • Discomfort with virtual reality experiences

This study, called LABYR (Labyrinth intervention in high-fidelity long-term memory), will determine if new, experiential challenges delivered in a virtual reality video game can improve long-term memory capabilities.

Each person will wear a head-mounted display to play a game running virtual errands while navigating through an unfamiliar, visually complex neighborhood. Participants will be randomly assigned to an intervention or a control. Memory tests will be conducted before and after the training period. Results will be measured by task and recall testing, functional MRI brain scans, and blood samples.

Name City State Zip Status Primary Contact
UCSF Mission Bay
San Francisco California 94158 Recruiting Melissa Arioli

University of California, San Francisco

Name Role Affiliation
Peter E Wais, PhD Principal Investigator Neuroscape, Department of Neurology

Name Phone Email
Melissa Arioli 415-502-7321
Sierra Niblett, MA 415-502-7321


Cognitive Intervention (VR) to Restore Capabilities for Learning and Retrieval of High-Fidelity Memory