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Find more clinical trials

Influence of Cognitive Training on Large-Scale Brain Networks in MCI

Start: October 30, 2017
End: December 2020
Enrollment: 60

What Is This Study About?

This study will examine the potential effects of computerized cognitive training on large-scale brain networks in older adults with mild cognitive impairment (MCI). Participants will be randomly assigned to receive six months of either computerized cognitive training or computerized crossword puzzles using a similar system, both to be done at home. Researchers will measure changes in executive function and memory at the start and end of the study using brain scans and neuropsychological tests to evaluate any differences in participants' large-scale structural and functional brain networks compared with the typical course of amnestic (memory-related) MCI.

Do I Qualify To Participate in This Study?

Minimum Age: 65 Years

Maximum Age: 85 Years

Must have:

  • Cognitive concern reported by subject, informant, or physician
  • Mild memory impairment (Mini-Mental State Examination score of 24 or higher)
  • Essentially normal functional activities

Must NOT have:

  • Any significant neurological condition, including probable dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, or brain tumor
  • Presence of Axis I disorder
  • Current use of psychoactive medications (permitted medications include cholinesterase inhibitors, hypertension medication, etc., for at least two months)
  • Claustrophobia or other reason that precludes MRI 
  • Any significant systemic or unstable medical condition

If I Qualify, Who Do I Contact?

Contact study personnel listed either under the general study contact or the location nearest you.

Need Help?

Contact NIA’s Alzheimer’s and related Dementias Education and Referral (ADEAR) Center at 800-438-4380 or email ADEAR.

Where Is This Study Located?

Who Sponsors This Study?

Lead: Stanford University

Collaborator Sponsor

  • National Institute on Aging (NIA)

Source: ClinicalTrials.gov ID: NCT03883308

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An official website of the U.S. government, managed by the National Institute on Aging at the National Institutes of Health