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Influence of Cognitive Training on Large-Scale Brain Networks in MCI


This study will examine the potential effects of 6 months of computerized cognitive training on large-scale brain networks in older adults with mild cognitive impairment (MCI). Results will be compared to those in a control group who receive online training in crossword puzzles.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years 85 Years All No
October 30, 2017
February 28, 2021

  • Cognitive concern reported by subject, informant, or physician
  • Mild memory impairment (Mini-Mental State Examination score of 24 or higher)
  • Essentially normal functional activities

  • Any significant neurological condition, including probable dementia, Parkinson's disease, Huntington's disease, multiple sclerosis, or brain tumor
  • Presence of Axis I disorder
  • Current use of psychoactive medications (permitted medications include cholinesterase inhibitors, hypertension medication, etc., for at least 2 months)
  • Claustrophobia or other reason that precludes MRI 
  • Any significant systemic or unstable medical condition

Participants will be randomly assigned to receive 6 months of either computerized cognitive training or computerized crossword puzzles using a similar system, both to be done at home. Researchers will assess changes in executive function and memory at the start of the study and after the training using brain scans and neuropsychological tests. They want to evaluate any differences in participants' large-scale structural and functional brain networks compared with the typical course of amnestic (memory-related) MCI.

Name City State Zip Status Primary Contact
Stanford University School of Medicine
Stanford California 94305 Recruiting Hadi Hosseini, PhD

Stanford University

  • National Institute on Aging (NIA)

Name Phone Email
Lindsay Chromik, MS 650-724-2939
Hadi Hosseini, PhD 650-724-2939


The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI