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Imaging Inflammation in Alzheimer's Disease with 11C-ER176


This study will test the ability of the radioactive tracer 11C-ER176 to stick to parts of the brain where there is inflammation. Past studies have shown that inflammation is present in the brains of people with Alzheimer's disease.

Minimum Age Maximum Age Gender Healthy Volunteers
50 Years N/A All Yes
September 10, 2018
July 20, 2021

  • Meet criteria for either a) amnestic mild cognitive impairment (MCI) or Alzheimer's disease, or b) have no cognitive impairment
  • If unable to provide informed consent, must have surrogate decision maker and be able to verbally assent to study procedures
  • Fluent in written and spoken English
  • Able to participate in all scheduled evaluations and to complete all required tests and procedures
  • Must be considered likely to comply with study protocol and have a high probability of completing the study

  • Past or present history of certain brain disorders other than MCI or Alzheimer's disease
  • Certain significant medical conditions that make study procedures unsafe, including uncontrolled epilepsy and multiple serious injuries
  • Inability to undergo magnetic resonance imaging, including metal implants, morbid obesity, and claustrophobia
  • Exposure to research-related radiation in the past year that would exceed allowable limits
  • Participation in the last year in a clinical trial for a disease-modifying Alzheimer's drug
  • Inability to have a catheter in the vein for the injection of the tracer
  • Inability to have blood drawn from veins
  • Taking anticoagulant medication (e.g., warfarin)

Positron emission tomography (PET) imaging is a type of brain scanning method that allows researchers to use radioactive tracers to measure small molecules in the brain. In this study participants will undergo PET scanning and blood sampling to measure 11C-ER176. Another type of dye, florbetaben, which has been approved by the U.S. Food and Drug Administration to help diagnose Alzheimer's disease, will also be used.

Name City State Zip Status Primary Contact
Columbia University Medical Center
New York New York 10032 Recruiting Aubrey Johnson

William Charles Kreisl

Name Role Affiliation
William C Kreisl, M.D. Principal Investigator Columbia University

Name Phone Email
Aubrey Johnson 212-305-9079


Imaging Inflammation in Alzheimer's Disease With 11C-ER176