Alzheimer's Disease Education and Referral Center

Imaging of Cognition, Learning, and Memory in Aging

Imaging of Cognition, Learning, and Memory in Aging

Overall Status: 
Brief Description: 

This investigation is designed to study how the brain functions when it performs explicit memory tasks and how the brain systems supporting performance on these tasks change as a function of aging.

Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
18 Years
85 Years
Inclusion Criteria: 

  • Age 18-30 or 65-85 years old
  • Residing in the community of Washington Heights/Inwood/Hamilton Heights in New York City

Exclusion Criteria: 

  • Contraindication to PET scanning (e.g, metallic implants, pacemaker, claustrophobia, or cannot lie flat for 1 hour)
  • Pregnancy
  • Lactating women
  • Current, past, or anticipated exposure to radiation
  • Significant active physical illness

Detailed Description: 

Explicit memory characterizes the directed or intentional recollection of previously learned information or events. In contrast, implicit (or nonconscious) memory is expressed without any conscious awareness of the prior presentation of the stimulus. Functional magnetic resonance imaging (fMRI) will measure brain activity during the performance of carefully designed, explicit memory tasks. Comparison of brain activity during different test conditions will provide information about the brain areas that are involved in specific aspects of performance. Both older and younger individuals will be tested to understand age-related changes in brain activity. To examine the interactions between participants' amyloid burden, performance on cognitive tasks, and fMRI neural activation, the investigators also propose PET imaging of older participants.

Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 40.8409822, -73.9447994

Columbia University Medical Center
New York
New York
Lead Sponsor: 
Columbia University
Collaborator Sponsor: 
National Institute on Aging (NIA)
Facility Investigators: 
Yaakov Stern, PhD
Principal Investigator
Columbia University
Study Contact: 
Daniel J. Barulli
212-305-9712 x 5-9712
Locations ID 
NCT01297114 (follow link to view full record on in new window)
Official Title: 
Imaging of Cognition, Learning, and Memory in Aging
Study Start Date: 
March 2011
Study End Date: 
December 2016