The purpose of this study is to determine if the menopausal transition is associated with cognitive decline that improves in menopause. The investigators predict that as women transition from early perimenopause to late perimenopause, their performance on attentionally mediated and verbal memory tasks will decline, and that as they transition from late perimenopause to menopause, their performance will improve.
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The investigators hypothesize that perimenopause is associated with both subjective memory complaints and objective declines in attentionally mediated cognitive tasks. The investigators also hypothesize that this is time-limited: As women transition from early perimenopause to late perimenopause, their performance on attentionally mediated and verbal memory tasks will decline, and as they transition from late perimenopause to menopause, their performance will improve.
Two groups of women will be recruited, those in early perimenopause and those in mid to late perimenopause. Tests of attention, working memory, mental flexibility, processing speed, and retentive memory will be administered to each subject at 6-month intervals for 5 years. Additionally, women will be asked to fill out questionnaires about their mood, memory functioning, health, and quality of life. The investigators will also calculate each subject's Body Mass Index (BMI) and waist circumference at each visit. Finally, serum levels of reproductive hormones will be taken. Outcomes include correlations between cognitive function, mood, and hormone levels.
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Geolocation is 43.1224766, -77.6242574
University of Rochester
National Institutes of Health (NIH)
National Institute on Aging (NIA)
Miriam Weber, PhD
Department of Neurology, University of Rochester