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Glutathione for Mild Cognitive Impairment


This exploratory trial will investigate the effects of a glutathione dietary supplement on cognitive function in adults with mild cognitive impairment (MCI).

Minimum Age Maximum Age Gender Healthy Volunteers
55 Years 85 Years All No
April 14, 2018
December 31, 2022

  • Diagnosis of MCI

  • Hospitalization within past 3 months
  • Diabetes
  • Creatinine levels greater than or equal to 1.5 mg/dL
  • Hemoglobin concentration less than 11 g/dL
  • Liver disease, or AST/ALT greater than or equal to two times the upper limit of normal
  • History of stroke, brain tumor, or active heart failure
  • History of psychiatric disorders
  • Untreated depression

Glutathione is an antioxidant that has been linked to cognition. Participants will take either N-acetylcysteine and glycine (glutathione precursors) or a placebo of alanine for 12 weeks. Researchers will measure changes in cognition and other effects at baseline, 12 weeks, and 24 weeks.

Name City State Zip Status Primary Contact
Baylor College of Medicine
Houston Texas 77030 Recruiting Rajagopal V Sekhar, MD

Baylor College of Medicine

  • Nantz National Alzheimer's Center, Methodist Hospital, Houston, TX

Name Role Affiliation
Rajagopal Sekhar Principal Invesitgator Baylor College of Medicine

Name Phone Email
Rajagopal V. Sekhar, MD 713-798-3908


Glutathione in Mild Cognitive Impairment