Evidence Amyloid Scan EEG Study (EASES)
The EASES study is a 2-year observational study designed to measure brain function during the onset and progression of mild cognitive impairment (MCI) in older adults using quantitative electroencephalography (qEEG).
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
- Medicare beneficiary
- Diagnosis of MCI or dementia (with Alzheimer's being a diagnostic consideration)
- Cognitive complaint verified by objectively confirmed cognitive impairment
- Brain magnetic resonance imaging and/or computed tomography scan within past 2 years
- Normal cognition or subjective complaints that are not verified by cognitive testing
- Knowledge of amyloid status could negatively impact the participant or family
- Scan ordered for nonmedical purposes (e.g., legal, insurance coverage, or employment screening)
- Cancer requiring active therapy (excluding non-melanoma skin cancer)
- Life expectancy less than 2 years
- Residence in a skilled nursing facility
qEEG is a noninvasive technique that records the brain's electrical activity. Participants will be scanned using a device that fits around the head and has electrodes attached. Results will be analyzed to see if there's a correlation between this electrical activity and levels of amyloid, a protein that accumulates abnormally in Alzheimer's brains, as seen on positron emission tomography scans. Researchers will evaluate whether qEEG can be used to differentiate healthy aging individuals from those developing MCI to help diagnose people in the early stages of preclinical Alzheimer's disease.
Translational Cognitive Research
Kenneth O. Russell
Metabolic Therapy Inc.
- Institute of Asian American Adult Development
Quantitative EEG for Assessment of Mild Cognitive Impairment Associated With Preclinical Alzheimer's Disease - Evidence for Amyloid Indication Study
- Smailovic U, Koenig T, Kreholt I, Andersson T, Kramberger MG, Winblad B, Jelic V. Quantitative EEG power and synchronization correlate with Alzheimer's disease CSF biomarkers. Neurobiol Aging. 2018 Mar;63:88-95. doi: 10.1016/j.neurobiolaging.2017.11.005. Epub 2017 Nov 16.
- Kramberger MG, Kreholt I, Andersson T, Winblad B, Eriksdotter M, Jelic V. Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort. Dement Geriatr Cogn Disord. 2013;36(5-6):319-28. doi: 10.1159/000351677. Epub 2013 Sep 10.
- Stomrud E, Hansson O, Minthon L, Blennow K, Rosn I, Londos E. Slowing of EEG correlates with CSF biomarkers and reduced cognitive speed in elderly with normal cognition over 4 years. Neurobiol Aging. 2010 Feb;31(2):215-23. doi: 10.1016/j.neurobiolaging.2008.03.025.
- Michel CM. Electrical Neuroimaging. Cambridge University Press, Cambridge 2009.
- Freire FR, Coelho F, Lacerda JR, da Silva MF, Gonalves VT, Machado S, Velasques B, Ribeiro P, Basile LFH, Oliveira AMP, Paiva WS, Kanda PAM, Anghinah R. Cognitive rehabilitation following traumatic brain injury. Dement Neuropsychol. 2011 Jan-Mar;5(1):17-25. doi: 10.1590/S1980-57642011DN05010004. Review.
- 1. Cassani R, Falk TH, Fraga FJ, Cecchi M, Moore DK, Anghinah R. Towards automated electroencephalography-based Alzheimer's disease diagnosis using portable low-density devices. Biomedical Signal Processing and Control. 2017,33:261-71.
- Pratap-Chand R, Sinniah M, Salem FA. Cognitive evoked potential (P300): a metric for cerebral concussion. Acta Neurol Scand. 1988 Sep;78(3):185-9.
- Olichney JM, Yang JC, Taylor J, Kutas M. Cognitive event-related potentials: biomarkers of synaptic dysfunction across the stages of Alzheimer's disease. J Alzheimers Dis. 2011;26 Suppl 3:215-28. doi: 10.3233/JAD-2011-0047.
- Cecchi M, Moore DK, Sadowsky CH, Solomon PR, Doraiswamy PM, Smith CD, Jicha GA, Budson AE, Arnold SE, Fadem KC. A clinical trial to validate event-related potential markers of Alzheimer's disease in outpatient settings. Alzheimers Dement (Amst). 2015 Oct 2;1(4):387-94. doi: 10.1016/j.dadm.2015.08.004. eCollection 2015 Dec.
- van Dinteren R, Arns M, Jongsma ML, Kessels RP. P300 development across the lifespan: a systematic review and meta-analysis. PLoS One. 2014 Feb 13;9(2):e87347. doi: 10.1371/journal.pone.0087347. eCollection 2014. Review.
- Polich J, Corey-Bloom J. Alzheimer's disease and P300: review and evaluation of task and modality. Curr Alzheimer Res. 2005 Dec;2(5):515-25. Review.
- Polich J, Ladish C, Bloom FE. P300 assessment of early Alzheimer's disease. Electroencephalogr Clin Neurophysiol. 1990 May-Jun;77(3):179-89.
- Frodl T, Hampel H, Juckel G, Brger K, Padberg F, Engel RR, Mller HJ, Hegerl U. Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's Disease. Psychophysiology. 2002 Mar;39(2):175-81.
- Bennys K, Portet F, Touchon J, Rondouin G. Diagnostic value of event-related evoked potentials N200 and P300 subcomponents in early diagnosis of Alzheimer's disease and mild cognitive impairment. J Clin Neurophysiol. 2007 Oct;24(5):405-12.
- Papaliagkas VT, Anogianakis G, Tsolaki MN, Koliakos G, Kimiskidis VK. Combination of P300 and CSF -amyloid(1-42) assays may provide a potential tool in the early diagnosis of Alzheimer's disease. Curr Alzheimer Res. 2010 Jun;7(4):295-9.
- Korzyukov O, Pflieger ME, Wagner M, Bowyer SM, Rosburg T, Sundaresan K, Elger CE, Boutros NN. Generators of the intracranial P50 response in auditory sensory gating. Neuroimage. 2007 Apr 1;35(2):814-26. Epub 2006 Dec 19.
- Golob EJ, Johnson JK, Starr A. Auditory event-related potentials during target detection are abnormal in mild cognitive impairment. Clin Neurophysiol. 2002 Jan;113(1):151-61.
- Green DL, Payne L, Polikar R, Moberg PJ, Wolk DA, Kounios J. P50: A candidate ERP biomarker of prodromal Alzheimer's disease. Brain Res. 2015 Oct 22;1624:390-397. doi: 10.1016/j.brainres.2015.07.054. Epub 2015 Aug 6.
- Boutros NN, Belger A. Midlatency evoked potentials attenuation and augmentation reflect different aspects of sensory gating. Biol Psychiatry. 1999 Apr 1;45(7):917-22.
- Amenedo E, Daz F. Ageing-related changes in the processing of attended and unattended standard stimuli. Neuroreport. 1999 Aug 2;10(11):2383-8.
- Azumi T, Nakashima K, Takahashi K. Aging effects on auditory middle latency responses. Electromyogr Clin Neurophysiol. 1995 Nov;35(7):397-401.
- Hubl D, Kleinlogel H, Frlich L, Weinandi T, Maurer K, Holstein W, Czekalla J, Dierks T. Multilead quantitative electroencephalogram profile and cognitive evoked potentials (P300) in healthy subjects after a single dose of olanzapine. Psychopharmacology (Berl). 2001 Nov;158(3):281-8.