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Enhanced Mediterranean Diet for Alzheimer's Disease Prevention


In this study researchers are investigating how the Mediterranean diet and low-fat eating patterns affect cognitive function and other measures, such as brain volume and blood pressure, in cognitively normal older adults.

Minimum Age Maximum Age Gender Healthy Volunteers
65 Years N/A All Yes
March 7, 2019
February 2023

  • Cognitively normal (Mini-Mental State Examination score greater than 25; AD8 score of 2 or less; no prior diagnosis of mild cognitive impairment, Alzheimer's disease or dementia; and not medically treated for cognitive impairment or dementia)
  • Speak English as a primary language
  • Live in the Kansas City metropolitan area
  • Body mass index of 20 to 40

  • Serious medical risk, such as type 1 diabetes, cancer, or recent cardiac event, including heart attack or angioplasty
  • Nut or fish allergy (does not include shellfish)
  • Specialized diet, such as vegan
  • Severe major depression or major psychiatric disorder that could interfere with study participation
  • Alcohol abuse (more than 3 drinks per day or total of 18 per week) or drug abuse
  • Do not have access to or independence over grocery shopping and meal preparation (for example, people living in a retirement community with reliance on dining facilities for meals)
  • Already consume a Mediterranean or low-fat diet
  • Prohibited medications: warfarin

Participants will be randomly assigned to either a Mediterranean or low-fat diet for 1 year. The Mediterranean diet consists of fruits, vegetables, grains, dairy, olive oil, seafood, and nuts. Additionally, participants will be randomized to take either 2 grams of an omega-3 fatty acid supplement or placebo. During the study, participants will track the food they eat, be monitored by a registered dietitian, and engage in monthly food demonstrations and cooking classes. They will also pick up a bag of groceries weekly for 6 months from a local grocery store. After 1 year, people may continue in the study for up to 2 years for additional measurements.

Name City State Zip Status Primary Contact
University of Kansas Medical Center
Kansas City Kansas 66160 Recruiting Juleah Littrell, MS, RD, LD

University of Kansas Medical Center

  • National Institute on Aging (NIA)

Name Role Affiliation
Debra K. Sullivan, PhD, RD Principal Investigator University of Kansas Medical Center

Name Phone Email
Juleah Littrell 913-588-6392


Enhanced Mediterranean Diet for Alzheimer's Disease Prevention