Enhanced Mediterranean Diet for Alzheimer's Disease Prevention
Recruiting
In this study researchers are investigating how the Mediterranean diet and low-fat eating patterns affect cognitive function and other measures, such as brain volume and blood pressure, in cognitively normal older adults.
Minimum Age | Maximum Age | Gender | Healthy Volunteers |
---|---|---|---|
65 Years | N/A | All | Yes |
- Cognitively normal (Mini-Mental State Examination score greater than 25; AD8 score of 2 or less; no prior diagnosis of mild cognitive impairment, Alzheimer's disease or dementia; and not medically treated for cognitive impairment or dementia)
- Speak English as a primary language
- Live in the Kansas City metropolitan area
- Body mass index of 20 to 40
- Serious medical risk, such as type 1 diabetes, cancer, or recent cardiac event, including heart attack or angioplasty
- Nut or fish allergy (does not include shellfish)
- Specialized diet, such as vegan
- Severe major depression or major psychiatric disorder that could interfere with study participation
- Alcohol abuse (more than 3 drinks per day or total of 18 per week) or drug abuse
- Do not have access to or independence over grocery shopping and meal preparation (for example, people living in a retirement community with reliance on dining facilities for meals)
- Already consume a Mediterranean or low-fat diet
- Prohibited medications: warfarin
Participants will be randomly assigned to either a Mediterranean or low-fat diet for 1 year. The Mediterranean diet consists of fruits, vegetables, grains, dairy, olive oil, seafood, and nuts. Additionally, participants will be randomized to take either 2 grams of an omega-3 fatty acid supplement or placebo. During the study, participants will track the food they eat, be monitored by a registered dietitian, and engage in monthly food demonstrations and cooking classes. They will also pick up a bag of groceries weekly for 6 months from a local grocery store. After 1 year, people may continue in the study for up to 2 years for additional measurements.
Name | City | State | Zip | Status | Primary Contact |
---|---|---|---|---|---|
University of Kansas Medical Center |
Kansas City | Kansas | 66160 | Recruiting |
Juleah Littrell, MS, RD, LD |
University of Kansas Medical Center
- National Institute on Aging (NIA)
Name | Role | Affiliation |
---|---|---|
Debra K. Sullivan, PhD, RD | Principal Investigator | University of Kansas Medical Center |
Name | Phone | |
---|---|---|
Juleah Littrell | 913-588-6392 | jlittrell2@kumc.edu |
Enhanced Mediterranean Diet for Alzheimer's Disease Prevention