Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers
This study will examine the effects of anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery. Two types of anesthesia, propofol and isoflurane, will be compared.
|Minimum Age||Maximum Age||Gender||Healthy Volunteers|
- Surgical patient
- Surgery scheduled to last at least 2 hours, including time for anesthesia induction
- Ability to speak English
- Inmate of a correctional facility
- Documented or suspected family or personal history of malignant hyperthermia
- Inability to receive either propofol or isoflurane due to allergy or other specific contraindication
In this study, researchers will compare the effects of two types of anesthesia on memory and other types of thinking during the 6 weeks after surgery in older individuals. They will also examine the impact on Alzheimer's disease biomarkers, specifically levels of the proteins tau and amyloid in cerebrospinal fluid, during the first 24 hours and 6 weeks after surgery.
Duke University Medical Center
Miles Berger, MD, PhD
Markers of Alzheimers Disease and Cognitive Outcomes After Propofol or Isoflurane Anesthesia