Alzheimer's Disease Education and Referral Center

Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

Effects of Anesthesia on Cognition and Alzheimer's Disease Biomarkers

Overall Status: 
Brief Description: 

This study will examine the effects of anesthesia on cognition and certain Alzheimer's disease biomarkers in older adults who undergo surgery. Two types of anesthesia, propofol and isoflurane, will be compared.


Patient Qualifications: 
Min AgeMax AgeGenderHealthy Volunteers
60 Years
Inclusion Criteria: 
    • Surgical patient
    • Surgery scheduled to last at least 2 hours, including time for anesthesia induction
    • Ability to speak English
Exclusion Criteria: 
    • Inmate of a correctional facility
    • Pregnancy
    • Documented or suspected family or personal history of malignant hyperthermia
    • Inability to receive either propofol or isoflurane due to allergy or other specific contraindication
Detailed Description: 

In this study, researchers will compare the effects of two types of anesthesia on memory and other types of thinking during the 6 weeks after surgery in older individuals. They will also examine the impact on Alzheimer's disease biomarkers, specifically levels of the proteins tau and amyloid in cerebrospinal fluid, during the first 24 hours and 6 weeks after surgery.

Map Marker CityStateZip CodeStatusPrimary Contact

Geolocation is 36.0038131, -78.9387241

Duke University Medical Center
North Carolina
Lead Sponsor: 
Duke University
Collaborator Sponsor: 
Facility Investigators: 
Miles Berger, MD, PhD
Principal Investigator
Duke University Medical Center, Anesthesiology Department, Neuroanesthesia Division
Study Contact: 
Miles Berger, MD, PhD
Alicia Pucci
Locations ID 
NCT01993836 (follow link to view full record on in new window)
Official Title: 
Markers of Alzheimers Disease and Cognitive Outcomes After Propofol or Isoflurane Anesthesia
Study Start Date: 
November 2013
Study End Date: 
January 2018