Dominantly Inherited Alzheimer Network (DIAN)
Recruiting
The purpose of this study is to identify potential biomarkers that may predict the development of Alzheimer's disease in people who carry an Alzheimer's mutation.
Minimum Age | Maximum Age | Gender | Healthy Volunteers |
---|---|---|---|
18 Years | N/A | All | Yes |
- Child of an individual with a known mutation for autosomal dominant Alzheimer's disease
- Cognitively normal; may allow enrollment of participants with very mild, mild, or moderate cognitive impairment
- Fluent at the 6th grade level in a language approved by investigators
- Has two people who are not siblings who can serve as sources for the study
- Medical or psychiatric illness that would interfere with completing initial and follow-up visits
- Requires nursing home level care
Dominantly inherited Alzheimer's disease represents less than 1% of all cases of Alzheimer's. It is an important model for study because the responsible mutations have known biochemical consequences that are believed to underlie the pathological basis of the disorder.
Three major hypotheses will be tested:
- There is a period of preclinical (presymptomatic) Alzheimer's disease in individuals who are destined to develop early-onset dementia (gene carriers) that can be detected by changes in biological fluids and in neuroimaging results compared with individuals who will not develop early-onset dementia (noncarriers).
- Because all identified causative mutations for Alzheimer's disease affect the normal processing of amyloid precursor protein (APP) and increase brain levels of amyloid-beta 42 (A42), the sequence of preclinical changes initially will involve A42 production and clearance and reduced levels in cerebrospinal fluid, followed by evidence for cerebral deposition of A42 (amyloid imaging), followed by cerebral metabolic activity (functional imaging), and finally by regional atrophy (structural imaging).
- The phenotype of symptomatic early-onset familial Alzheimer's, including its clinical course, is similar to that of late-onset "sporadic" Alzheimer's.
The following specific aims will be used to test these hypotheses:
1. Establish an international, multicenter registry of individuals (mutation carriers and noncarriers; presymptomatic and symptomatic) who are biological adult children of a parent with a known causative mutation for Alzheimer's disease in the APP, PSEN1, or PSEN2 genes.
2. In presymptomatic individuals, compare mutation carriers and noncarriers to determine the order in which changes in clinical, cognitive, neuroimaging, and biomarker indicators of Alzheimer's disease occur prior to dementia.
3. In symptomatic individuals, compare the clinical and neuropathological phenotypes of autosomal dominant Alzheimer's to those of late-onset "sporadic" Alzheimer's.
4. Maintain the DIAN Central Archive, an integrated database incorporating all information obtained from individuals in the registry, to permit analyses among the various data domains and to disseminate the data to qualified investigators.
5. All DIAN participants who wish to know their mutation status will have the costs of genetic counseling and clinical mutation testing paid for by the grant. The clinical genetic counseling and testing are provided as an optional participant benefit and are not part of the DIAN research design.
Name | City | State | Zip | Status | Primary Contact |
---|---|---|---|---|---|
Mayo Clinic Jacksonville |
Jacksonville | Florida | 32224 | Recruiting |
Sochenda Chea, BHA CRC 904-953-3234 chea.sochenda@mayo.edu |
Indiana University-Indiana Alzheimer Disease Center |
Indianapolis | Indiana | 46202 | Recruiting |
Jill Buck, RN 317-963-1847 jilmbuck@iu.edu |
Brigham and Women's Hospital |
Boston | Massachusetts | 02115 | Recruiting |
Paige Sparks, BA 617-643-7799 kpsparks@bwh.harvard.edu |
Washington University School of Medicine |
Saint Louis | Missouri | 63108 | Recruiting |
Wendy Sigurdson, RN, MPH 314-362-2256 sigurdsonw@neuro.wustl.edu |
Columbia University |
New York | New York | 10032 | Recruiting |
Katie Neimeyer 212-305-5909 Kn2416@cumc.columbia.edu |
University of Pittsburgh |
Pittsburgh | Pennsylvania | 15260 | Recruiting |
Zana Ikonomovic, MD 412-692-2740 ikonomovics@upmc.edu |
Butler Hospital |
Providence | Rhode Island | 02906 | Recruiting |
Courtney Bodge, PhD 401-455-6403 cbodge@butler.org |
Washington University School of Medicine
- National Institute on Aging (NIA)
Name | Role | Affiliation |
---|---|---|
Randall J. Bateman, MD | Principal Investigator | Washington University School of Medicine |
Name | Phone | |
---|---|---|
DIAN Global Coordinator | 314-747-1940 | olivera@abraxas.wustl.edu |
Dominantly Inherited Alzheimer Network (DIAN)
- Mintun MA, Larossa GN, Sheline YI, Dence CS, Lee SY, Mach RH, Klunk WE, Mathis CA, DeKosky ST, Morris JC. [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease. Neurology. 2006 Aug 8;67(3):446-52.
- Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol. 2007 Mar;64(3):343-9. Epub 2007 Jan 8.
- Godbolt AK, Cipolotti L, Anderson VM, Archer H, Janssen JC, Price S, Rossor MN, Fox NC. A decade of pre-diagnostic assessment in a case of familial Alzheimer's disease: tracking progression from asymptomatic to MCI and dementia. Neurocase. 2005 Feb;11(1):56-64.
- Morris JC, McKeel DW Jr, Storandt M, Rubin EH, Price JL, Grant EA, Ball MJ,