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Distinguishing Between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Recruiting

This study will use a variety of assessments and clinical and biological measures to characterize adults with three different disorders: Alzheimer's disease, Lewy body dementia, and Parkinson's disease.

Minimum Age Maximum Age Gender Healthy Volunteers
18 Years N/A All No
November 2018
December 2020
76

  • Meet standard clinical criteria for Alzheimer's disease, Lewy body dementia, or Parkinson's disease
  • Mini-Mental State Examination score of 10 or more
  • If taking cognitive or psychoactive medication, must be on stable dose for at least 4 weeks before enrollment
  • Study partner who lives with participant or has contact at least 4 days per week
  • Visual and hearing ability sufficient to complete testing

  • Any condition other than Alzheimer's disease, Lewy body dementia, or Parkinson's disease that might contribute to dementia or complicate its assessment
  • Active medical disorder that could interfere with participation
  • Women who are pregnant or are breastfeeding
  • Severe kidney impairment 
  • English is not the individual's first language
  • Educational level less than 12 years
  • Participation in an experimental study with an amyloid-targeting agent unless participant received a placebo

Participants will undergo a clinical evaluation, physical exam, neurological exam, genetic blood sample collection, neuropsychological testing, sleep study, and neuroimaging, including magnetic resonance imaging and positron emission tomography. The study partner will also be interviewed for assessments of behavior and function.

Name City State Zip Status Primary Contact
The Ohio State University
Columbus Ohio 43210 Recruiting Jennifer Icenhour
614-293-6882
jennifer.icenhour@osumc.edu

Douglas Scharre

  • Avid Radiopharmaceuticals
  • Mangurian Foundation

Name Role Affiliation
Douglas W. Scharre, MD Principal Investigator Ohio State University

Name Phone Email
Jennifer Icenhour 614-293-6882 jennifer.icenhour@osumc.edu

NCT03019757

Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease